<![CDATA[Ischemic stroke is caused by blood vessel occlusion that disrupts cerebral blood flow and may result in neurological impairment with varying degrees of severity. Leukocytes and platelets are known to play important roles in the inflammatory process and thrombus formation underlying the pathogenesis of ischemic stroke. This study aimed to determine the relationship between the platelet-to-leukocyte ratio and the initial clinical severity of acute ischemic stroke based on the National Institutes of Health Stroke Scale (NIHSS) score. This study employed a cross-sectional design with an analytical observational approach. Data were obtained from the medical records of 90 patients diagnosed with acute ischemic stroke at Abdoel Wahab Sjahranie Regional General Hospital, Samarinda, from January 2023 to March 2024. Samples were selected using purposive sampling. Bivariate analysis was performed using a One-Way ANOVA test to determine the relationship between the platelet-to-leukocyte ratio and the initial clinical severity of ischemic stroke. The results showed no significant relationship between the platelet-to-leukocyte ratio and the initial clinical severity of acute ischemic stroke based on the NIHSS score (p = 0.207). Therefore, the platelet-to-leukocyte ratio cannot yet be used as a single indicator to describe the initial clinical severity of patients with acute ischemic stroke.]]>
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