<![CDATA[Chemistry learning in senior high schools is often considered difficult because many topics are abstract in nature, such as chemical reactions and the fundamental laws of chemistry. Based on the results of observations and interviews conducted at SMA Negeri 3 Waingapu, the learning process is still dominated by the lecture method, and laboratory practical activities are limited. As a result, many students experience difficulties in understanding the subject matter. Of the 36 students, approximately 65% had not achieved the Learning Objectives Achievement Indicator (IKTP). Therefore, a more interactive and engaging learning medium is needed to help students understand chemistry concepts more effectively. This study aims to design and develop an interactive multimedia simulation game as a learning medium for chemistry, implement the Decision Tree algorithm within the game system, and improve students' understanding of chemistry concepts. The expected benefits of this study are to provide a more engaging learning medium for students and to assist teachers in delivering chemistry lessons more effectively. The development method used in this research is the Multimedia Development Life Cycle (MDLC), which consists of six stages: concept, design, material collecting, assembly, testing, and distribution. Data were collected through observations, interviews, and questionnaires. The application was developed using Unity with the C# programming language and deployed on the Android platform. System testing was carried out using the Black Box Testing method. The proposed solution is an interactive multimedia simulation game that provides learning materials, chemical reaction simulations, and interactive quizzes. The system inputs consist of menu selections and quiz answers provided by users. The system processes include presenting learning materials, running chemical reaction simulations, and evaluating quiz answers using the Decision Tree algorithm. The outputs generated include quiz scores, learning evaluation results, and feedback to students regarding their learning performance.]]>
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