Economic growth is an important indicator for assessing a region's welfare, including in Southern Sumatra (Sumbagsel). However, economic disparities and high poverty levels remain in several provinces in the region. On the other hand, the potential of zakat as an Islamic economic instrument has not been optimally utilized in encouraging economic growth and poverty reduction, This study aims to determine whether zakat, HDI, and poverty have an impact on economic growth in the South Sumatra region during the 2020-2024 period in an Islamic economic perspective, The type of research in this study is quantitative and this study uses a panel data regression research method, The results of this study indicate that simultaneously the variables of zakat, human development index and poverty have a significant effect on economic growth in the South Sumatra region. Partially, the variables show that Zakat and HDI have a positive and significant effect on economic growth in South Sumatra, while poverty has a negative and insignificant effect on economic growth in the South Sumatra region.
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