Uji Aktivitas Anti-inflamasi Dan Daya Hambat Siklooksigenase-2 ekstrak etanol Daun Malur (Brucea javanica (L.) Merr.)

Ifora Ifora (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Diana Haryani (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Rahmad Abdillah (Fakultas Farmasi Universitas Andalas)

Journal of Pharmaceutical and Sciences.
Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)

Inflammation is a normal protective response to tissue damage mediated by Cyclooxigenase-2 (COX-2) enzyme. This study aims to determine the anti-inflammatory activity ethanol extract of (Brucea javanica (L.) Merr.) and its inhibitory effect on COX-2 enzyme. The animals used in this study were male white rats which were divided into 5 groups, dose250 mg/kg BB, dose 500 mg/kg BB, comparative control (Celecoxib), positve control and negative controls. Determining of anti-inflammatory activity was carried out by inducing the soles of the Rats with carragen and then measuring the edema volume using a pletismometer and measuring COX-2 inhibiton using a microplate Reader. The results showed that the ethanol extract of malur leaves doses 250 mg/kg BB and 500 mg/kg BB had significant anti-inflammatory activity (p <0.05). The dose 500 mg/kg BB has a significant inhibitory effect on COX-2 (p <0.05), but dose 250 mg/kg BB does not have significant inhibitory effect on COX-2. It can be concluded that the ethanol extract of malur leaves has anti-inflammatory effects at doses 250 mg/kg BB and 500 mg/kg BB and inhibitory effect against COX-2 at a dose 500 mg/kg BB.