REVIEW : ANALISIS EFEKTIFITAS BIAYA PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIPHOID ANAK DI INDONESIA

Desy Natalia Siahaan (Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Indonesia)
Fenny Hasanah (Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Indonesia)
Eva Sartika Dasopang (Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Indonesia)
Rini Agnesia Ndruru (Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Indonesia)

Journal of Pharmaceutical and Sciences.
Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022)

Indonesia is one of the endemic areas for typhoid fever with the majority of the incidents occurring in the age group 3-19 years (91% cases) (Cammie F. L. 2005; Brusch, J.L.,2010; IDAI, 2008). The high incidence of typhoid fever requires a pharmacoeconomic evaluation to get the best therapy in terms of economic value. One of the methods used is the method of Cost-Effectiveness Analysis. The purpose of this research is to find out which antibiotic has the most cost-effectiveness based on the ACER value obtained from various sources of articles published in 2016- 2021. This method is used related to the current pandemic period were preventing the transmission of COVID-19 activities is increasingly being limited, one of which is avoiding face-to-face meetings in research. The results showed that typhoid fever was more common in boys with an age range of under 12 years. The antibiotics most commonly used are chloramphenicol, thiamphenicol, ceftriaxone, cefixime, cefotaxime, ampicillin, and amoxicillin. The most Cost Effectiveness based on ACER value (Rp. /day free of fever) is Ceftriaxone.