<![CDATA[Hemodialysis is a renal replacement therapy routinely performed in patients with chronic kidney disease and may cause various physical and psychological problems, including stress. Stress levels in hemodialysis patients are influenced by several factors such as fatigue, pain, and discomfort during treatment. This study aimed to describe the factors affecting stress levels in hemodialysis patients. This study employed a quantitative descriptive survey design. The subjects consisted of 200 patients undergoing hemodialysis at Dr. Loekmono Hadi Kudus Regional General Hospital, selected using purposive sampling. Data were analyzed using univariate analysis with frequency distribution. The results showed that most respondents experienced moderate fatigue (58.5%), severe pain (41.5%), discomfort (58.5%), and moderate stress levels (70%). The study concludes that fatigue, pain, and discomfort are dominant factors experienced by hemodialysis patients and contribute to their stress levels. Therefore, comprehensive nursing interventions are needed to reduce stress and improve the quality of life of hemodialysis patients.]]>
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