The correlation of consuming thymoquinone extract of nigella sativa to tooth socket re-epithelization on diabetic-induced rats

Mei Syafriadi (Department of Biomedical Science, Laboratorium of Oral Pathology, Faculty of Dentistry, Jember University, Jember, Indonesia)
Putri R. Yusuf (Department of Biomedical Science, Laboratorium of Oral Pathology, Faculty of Dentistry, Jember University, Jember, Indonesia)
Sabrina M. Pratama (Department of Biomedical Science, Laboratorium of Oral Pathology, Faculty of Dentistry, Jember University, Jember, Indonesia)
Dina Z. Ummah (Department of Biomedical Science, Laboratorium of Oral Pathology, Faculty of Dentistry, Jember University, Jember, Indonesia)
Khoirul Amalia (Department of Biomedical Science, Laboratorium of Oral Pathology, Faculty of Dentistry, Jember University, Jember, Indonesia)

Journal of Dentomaxillofacial Science
Vol. 3 No. 2 (2018): (Available online: 1 August 2018)

Objective: The purpose of this research is to determine the effect of Tq to re-epithelialization at the margin of tooth socket post-extraction in diabetic rats.Material and Methods: Used 27 rats were induced diabetic with streptozotocin (STZ) dose of 50 mg/kg body weight of rats which divided into 3 groups that has been stained with hematoxillin-eosin and cytokeratin 19. They are P1 treated with thymoquinone (Tq), P2 treated with metformin, and K without treatment. Each group consist of 9 rats were divided into 3 subgroups based on day of observation. They are 3rd, 7th and 10th day post-extraction. Re-epithelialization was observed at the margin of the tooth socket that has been stained with hematoxillin-eosin and cytokeratin 19Results: showed there was an improvement of re epithelialization percentage in the Tq treatment group compared with P2 and K groups.Conclusion: Thymoquinone extract may decrease blood glucose level and increasing re-epithelialization in margin of the tooth socket after extraction in diabetic rats.