<![CDATA[Introduction: Caesarean section (CS) is one of port d’ entrée from
infection in women and it is related to maternal morbidity during
puerpureal period. Until now, there is still lack of consensus
regarding prophylactic antibiotic protocol before CS procedure. This
study aims to determine the comparative efficacy between single
dose and multiple doses of cefazolin prior incision toward the
incidence of maternal infection.
Methods: This was a single-blind, randomized, clinical trial study
with two methods of intervention including 2-gram single dose
cefazolin at 30 minutes’ prior incision and 2-gram single dose
cefazolin at 30 minutes’ prior incision continued 1-gram cefazolin
after 8 hours of procedure. We recruited women undergone elective
CS at Fatmawati and Anna Hospital, Jakarta from January to March
2016. The primary outcomes were surgical site infection, urinary
tract infection, and endometritis based on clinical findings during 30
days of follow-up period.
Results: A total of 46 subjects were recruited which 23 of them were
in single dose cefazolin group and the other 23 subjects were in
multiple dose of cefazolin group. There were 9 subjects having
infection (19.6%). There was no statistical difference in the
incidence of infection between two groups (p=1.00; relative risk
0.80, 95% CI 0.25-2.61).
Conclusion: Single dose of cefazolin shows similar rates of infection
incidence to multiple dose. Therefore, single dose of cefazolin can be
a protocol in CS based on its efficacy and efficiency.
[Indones J Obstet Gynecol 2017; 5-1: 60-65]
Keywords: cefazolin, maternal infection, multipe dose, single dose]]>
Copyrights © 2017
