Efficacy of 600 μg Misoprostol compare to 400 μg Misoprostol orally for expulsion of conception mass on pregnancy failure under twenty two weeks of gestational age

Rosa, Rahmedi

Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume. 34. No. 2, April 2010

Objective: To evaluate the efficacy and adverse effect of misoprostol
in pregnancy termination under 22 weeks of gestation with
dosage 400 μg, in comparison to 600 μg.
Method: The research was performed in Obstetric and Gynecology
Division in Dr. Cipto Mangunkusumo General Hospital to 70
subjects which were chosen with consecutive sampling, divided into
two groups with block randomization and double blind. Group A received
400 μg of misoprostol every 6 hours while group B received
600 μg of misoprostol every 6 hours for a maximum of 2 days. Each
group was evaluated for the time it took to reach complete abortion
and for the adverse effects, consisting of abdominal cramping,
bleeding, vomiting, and diarrhea.
Result: Success rate for termination with misoprostol 400 μg
and 600 μg were 88.5% and 91.4%, with no statistical difference
found (p=1.000). There was no difference in the time for reaching
complete abortion between two dosages (p=0.701) with a mean of
22 ± 8 hours. Adverse effects were found more frequent and more
severe in the group consuming 600 μg of misoprostol compared to
the group receiving 400 μg of misoprostol.
Conclusion: Four hundred micrograms of misoprostol every six
hour is recommended for termination of pregnancy under 22 weeks
of gestational age, without statistical difference in efficacy, but with
lower adverse effects.
[Indones J Obstet Gynecol 2010; 34-2: 59-63]
Keywords: misoprostol, pregnancy failure, dosage, efficacy, adverse
effect