<![CDATA[Objective: To evaluate the role of estrogen as a menopausal biochemical
marker to c-telopeptide (CTx) and IL-6 as a biochemical
marker of mineral bone density in perimenopausal women.
Method: This is an observational, cross-sectional study in perimenopausal
women between 45 - 51 years old, who matched the inclusion
and exclusion criteria such as no contraception was taken
before, no specific disease that could affect the laboratory findings.
Samples were taken from outpatients clinic of Prof Dr. R.D. Kandou
hospital. The patients were gathered for blood samples collection.
Blood samples were tested in laboratory. All data were collected and
being processed statistically using Pearson correlation coefficient
(SPSS version 16).
Result: From 60 perimenopausal women (45 - 51 years old)
sample, mean age was 47.98 ± 2.26 SD. Estrogen (estradiol) level:
< 10 pg/ml, maximum 358 pg/ml, and mean 77.11 ± 86.2 SD. IL-6
level: minimum is 1.645 pg/ml, maximum 7.771 pg/ml, and mean
4.317 ± 2.112 SD. We found significant correlation between age and
estrogen level (correlation level < 0.05) and CTx level (in level <
0.01). From regression curve, age has no significant correlation with
IL-6 concentration. However, we found significant correlation between
estradiol and CTx and IL-6 with respective correlation coefficient
value of < 0.01. Likewise the correlation between CTx and IL-
6 showed significant statistically with the value of the correlation
coefficient < 0,01.
Conclusion: There is a significant correlation between estrogen,
Il-6 and CTx. These variables play an important role in the occurrence
of the physiological changes in the perimenopausal women.
This study also showed the occurrence of a bone reabsorption process
that was marked by the increase of CTx level in accordance
with the increase in the age and the increase in the level of CTx together
with the decline in the level of oestrogen. Therefore, prevention
therapy of osteoporosis should begin in earlier age, before the
further bone reabsorption take place.
[Indones J Obstet Gynecol 2010; 34-2: 84-8]
Keywords: c-telopeptide, bone mineral density, estrogen, interleukin-
6, perimenopause women]]>
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