Objective: To evaluate clinical value of basal anti-Mullerian
Hormone level as predictor of ovarian response to stimulation in
women following in vitro fertilization program; compared with Follicle
Stimulating Hormone (FSH), estradiol and basal antral follicle.
Method: Research was conducted in Yasmin Clinic Cipto Mangunkusumo
Hospital as tertiary referral center for reproductive
health and in vitro fertilization. Infertile patients which going to undergo
controlled ovarian hyper stimulation cycle for in vitro fertilization
were checked for basal FSH level, estradiol level, AMH level
and amount of basal antral follicle. We were divided the sample into
two categories; poor responders and good responders. Statistical
analysis using ANOVA was done to evaluate demographic data and
Receiver Operator Characteristic area under curve (ROCAUC), and to
analyze whether AMH was more superior than the other 3 predictors
and to get the cut off point for AMH level.
Result: We have collected 22 patients data; 14 were categorized
as good responders and 8 were bad responders. Mean AMH value
in the good responders group was 4.46±1,01 and in the poor responders
group was 1,35±0,96, with p 0,000. According to ROCAUC,
AMH is a good predictor for good ovarian response in patient who
are a good responders (AUC 0,821), compared to the other three
predictors (FSH, E2 and basal antral follicle). Anti Mullerian Hormone
cut-off point level is 3, which means value
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