Increment of placental Caspase 3 expression in preeclampsia and its effect on birth weight and blood pressure

Teguh, Mintareja

Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume. 34, No. 1, January 2010

Objective: To determine the placental apoptosis process in preeclampsia.
Methods: This study was an observational analytical study using
cross sectional design. This study was performed at Dr. Hasan
Sadikin Hospital, during April to June 2008. Immunohistochemical
analysis was used to examine the placental expression of kaspase 3.
Results: Placental expression kaspase 3 was significantly higher
in preeclampsia group (21,9%) than in the normal pregnancies (0)
with p=0,006. There was significantly correlation between placental
kaspase 3 with birth weight in preeclampsia on the otherhand, there
was no significant difference of placental expression kaspase 3 with
birth weight in normal pregnancies. There was no significant difference
of placental expression kaspase 3 with mother’s blood pressure
in the two group.
Conclusion: there is a significant increase of placental expression
of kaspase 3 in preeclampsias.
[Indones J Obstet Gynecol 2010; 34-1:3-6]
Keywords: caspase 3, preeclampsia, apoptosis.