<![CDATA[Objective: To evaluate the theurapeutic response and acute toxicity
of neoadjuvant chemotherapy between the combination of Platinum
and Ifosfamide, and the combination of Platinum, Vincristine and
Bleomycin in Cervical Carcinoma Stage IB2 and then continued with
radical hysterectomy and pelvic lymphadenectomy.
Method: Thirteen samples received neoadjuvant chemotherapy of
Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy
of Platinum, Vincristine and Bleomycin, after receiving
the neoadjuvant chemotherapy, clinically complete response samples
underwent radical hysterectomy and pelvic lymphadenectomy
(PI VS PVB = 3 VS 1). Histopathology examination was performed to
evaluate the presence of malignant viable cells at the cervix, pelvic
lymph node metastasis and parametrium metastasis. Acute toxicity
evaluation was performed based on gastrointestinal, genitourinarius
and hematology sign and symptom.
Result: Theurapeutic response of PI is 1.12 higher than PVB
(p>0.05). Subanalysis of group response of PI is 1.962 higher than
PVB. PI and PVB have the same risk to have pelvic lymph node metastasis,
but not parametrial metastasis. There were no differences
in terms of the risk of gastrointestinal, genitourinarius and hematologic
toxicity between PI and PVB.
Conclusion: There was no statistical difference in clinical and
pathological response, and also in acute toxicity between the two
combination (p>0.05).
[Indones J Obstet Gynecol 2016; 1: 47-51]
Keywords: acute toxicity, cervical carcinoma stage IB2, neoadjuvant
chemotherapy, response]]>
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