High Level of Tumor Necrosis Factor (TNF)-α is a Risk Factor for Preeclampsia

Anom, I.G.N.

Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume. 36, No. 3, July 2012

Objective: To define that elevated TNF-α serum level was the risk factor of preeclampsia in pregnancy.

Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-α was obtained at Prodia’s clinical Laboratory Denpasar. Data’s normality test was done with Kolmogorov-Smirnov, then an analysis of data was done with Independent Sample Test, predictive value a = 0.05.
To define the role of TNF-α level in preeclampsia, Chi-Square test was chosen.

Result: From this research we found the average level of TNF-α in preeclampsia (6.64 ± 7.64 pg/ml) was higher than in normal pregnancy (2.42 ± 1.77 pg/ml). Analysis with t-independent test shows that the t-value was 2.85 and p-value was 0.006, which means that the average level of TNF-α between the two group was significantly
different (with predictive value, p