<![CDATA[Objective: To determine the most effective dose of estradiol
valerat (daily oral administration of 1 mg or 2 mg for 14 days) to
improve squamous epithel maturation of Pap Smear on postmenopausal
women.
Method: Seventy one postmenopausal women with atrophic Pap
Smear were participated in this randomized double blind clinical
trial. 35 subjects received estradiol valerat 1 mg and the other 36
subjects received estradiol valerat 2 mg. After daily oral administration
of estradiol valerat for 14 days, second Pap Smear were performed
to evaluate epithel maturation. The side effects were also
evaluated in this study.
Result: There were 5 subjects whom lost to follow up due to refused
to perform second Pap Smear and 1 subject was drop out due
to nausea. 65 subjects were included in final analysis. Estradiol
valerat 2 mg was significantly more effective than estradiol valerat
1 mg in improving epithel maturation of Pap Smear preparation on
postmenopausal women. There were no complain about nausea and
vaginal bleeding. Leukorhea occurred more frequently in the 2 mg
group.
Conclusion: Daily oral administration of 2 mg estradiol valerat
was more effective than estradiol valerat 1 mg in improving
squamous epithel maturation of Pap Smear on postmenopausal
women with minimal side effect (leukorhea).
[Indones J Obstet Gynecol 2010; 34-2: 89-91]
Keywords: Pap Smear, postmenopausal women, estradiol valerat,
epithel maturation of Pap Smear]]>
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