<![CDATA[Objective: To determine the serum concentration of Th-1 and
Th-2 cytokine in threatened preterm labor compared to that in normal
pregnancy.
Method: The design was analytical cross-sectional, comparing
the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and
IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor
and 29 normal pregnant women. The cytokine concentration was
measured with ELISA. T test and Mann-Whitney U test was used
for statistical analysis.
Results: The mean concentration of TNF-α and IL-2 in both
groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor
(PTL) group was observed higher than that observed in the normal
pregnancy group (p = 0.001). Compared to normal pregnancy group,
the TNF-α to IL-10 ratio in the PTL group was observed lower (p
= 0.009). Both groups did not show any difference in the IL-2 to
IL-10 ratio (p = 0.057).
Conclusion: The IL-10 serum concentration was increased in
threatened preterm labor. There was no difference observed in the
Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as
compared to normal pregnancy.
[Indones J Obstet Gynecol 2010; 34-4: 191-4]
Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokines]]>
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