Silver Nanoparticles Supported on Chitosan as a Green and Robust Heterogeneous Catalyst for Direct Synthesis of Nitrogen Heterocyclic Compounds under Green Conditions

Seyedeh Fazileh Fazileh Hamzavi (Department of Marine Biology, Science and Research Branch, Islamic Azad University, Tehran)
Shahla Jamili (Department of Marine Biology, Science and Research Branch, Islamic Azad University, Tehran|Iran Iranian Fisheries Science Research Institute, Agricultural Research Education and Extension Organization, Tehran)
Morteza Yousefzadi (Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandarabbas)
Ali Mashinchian Moradi (Department of Marine Biology, Science and Research Branch, Islamic Azad University, Tehran)
Narges Amrollahi Biuki (Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandarabbas)

Bulletin of Chemical Reaction Engineering & Catalysis
2019: BCREC Volume 14 Issue 1 Year 2019 (April 2019)

The catalytic efficiency of silver nanoparticles supported on chitosan as a green, robust, and efficient nanocatalyst for the direct synthesis of biologically active compounds, such as: imidazole derivatives as well as pyrazine scaffolds through multi-component reactions strategy, have been demonstrated. In this work, imidazole derivatives were achieved via pseudo four-component reactions by utilization of benzaldehydes, benzils, anilines, and ammonium acetate under solvent-free conditions. Moreover, pyrazine scaffolds were synthesized through a three-component reaction of phenylenediamine derivatives, isocyanides and various ketones in water. The main advantages of this protocol are the  reusability of the catalyst, operational simplicity, mild reaction conditions, and high-yielding.