SINTESIS XANTON DARI ASAM 2-PHENOXYBENZOIC ACID SEBAGAI BAHAN DASAR OBAT MALARIA BARU

Amanatie Amanatie (Kirnia-FMIPA Universitas Negeri Yogyakarta, J1.Colombo No.1, Yogyakarta 55281)
Jumina Jumina (Kirnia-FMIP A Universitas Gadjah Mada, J1. Bulaksumur Yogyakarta)
Mustofa Mustofa (Fakultas Kedokteran Universitas Gadjah Mada, J1. Bulaksumur Yogyakarta)
M. Hanafi (Pusat Penelitian Kimia-LIPI, Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 1531)

Jurnal Kimia Terapan Indonesia
Vol 15, No 2 (2013)

Synthesis of xanthone was conducted from the raw material of 2-phenoxybenzoic acid through acid-catalyzed-cyclization. The product was characterized using UV- Vis, 1 13 d FT-IR, H-NMR, C-NMR, an LC-MS Cyclization of 2-phenoxybenzoic acid using sulfuric acid catalyt gave xanthone in 86.11 % yield. These compounds as the basis of new malaria drugs.Keywords 2-phenoxybenzoic acid, Synthesis, Xanthone, Characterized.