<![CDATA[Lung imaging and computer aided diagnosis (CAD) play a critical role in detection of lung diseases. The most significant part of a lung based CAD is to fulfil the parenchyma segmentation, since disease information is kept in the parenchyma texture. For this purpose, parenchyma segmentation should be accurately performed to find the necessary diagnosis to be used in the treatment. Besides, lung parenchyma segmentation remains as a challenging task in computed tomography (CT) owing to the handicaps oriented with the imaging and nature of parenchyma. In this paper, a cascade framework involving histogram analysis, morphological operations, mean shift segmentation (MSS) and region growing (RG) is proposed to perform an accurate segmentation in thorax CT images. In training data, 20 axial CT images are utilized to define the optimum parameter values, and 150 images are considered as test data to objectively evaluate the performance of system. Five statistical metrics are handled to carry out the performance assessment, and a literature comparison is realized with the state-of-the-art techniques. As a result, parenchyma tissues are segmented with success rates as 98.07% (sensitivity), 99.72% (specificity), 99.3% (accuracy), 98.59% (Dice similarity coefficient) and 97.23% (Jaccard) on test dataset.]]>
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