Hubungan antara Kadar D-Dimer Hari Pertama Masuk Rumah Sakit dan Hari Ketujuh dengan Tampilan Klinis pada Pasien Stroke Iskemik Akut

Ayu Nurul Zakiah

Majalah Kedokteran Nusantara The Journal Of Medical School
Vol 51, No 2 (2018): The Journal of Medical School

AbstrakPendahuluan: Stroke merupakan ancaman terbesar menimbulkan kecacatan pada manusia. Diagnosisstroke iskemik berdasarkan pemeriksaan klinisi, pencitraan otak dan laboratorium (d-dimer). Menurutbeberapa penelitian, d-dimer meningkat dengan meningkatnya keparahan stroke, terutama pada stroketromboembolik.Metode: Penelitian kohort prospektif dari bulan Agustus - September 2016 terhadap 30 pasien strokeiskemik akut dan dilakukan anamnesis, Computed Tomography (CT) scan kepala, pengukuran tinggibadan, berat badan, indeks massa tubuh, Hemorrhagic Screening Test (HST), d-dimer hari pertama danhari ketujuh serta skor Indeks Barthel hari pertama dan hari ketujuh.Hasil: Dari 30 subyek, terdapat perbedaan bermakna rerata kadar d-dimer hari pertama dan hari ketujuh(p<0.05). Terdapat perbedaan bermakna skor Indeks Barthel hari pertama dan hari ketujuh (p<0.05).Terdapat korelasi negatif yang rendah kadar d-dimer hari pertama dengan skor Indeks Barthel haripertama (r=-0.383; p<0.05). Terdapat korelasi negatif sedang kadar d-dimer hari ketujuh dengan skorIndeks Barthel hari ketujuh (r=-0.576;p<0.05).Kesimpulan: Terdapat korelasi negatif antara kadar d-dimer dengan skor Indeks Barthel pada pasienstroke iskemik akutKata kunci: d-dimer, tampilan klinis, Indeks Barthel, stroke iskemikAbstractIntroduction: Stroke, one of the biggest threats is the cause of disability in people's lives. The diagnosisof ischemic stroke based on examination of clinicians, plus the brain imaging and laboratoryexaminations (d-dimer). According to some research, the d-dimer levels increased with increasingseverity of stroke, especially on stroke thromboembolic.Methods: A prospective cohort study from August - September 2016 against 30 acute ischemic strokepatients and anamnesis, a head Computed Tomography (CT) scan, the measurement of height, weight,body mass index, Hemorrhagic Screening Test (HST), d-dimer first day and the seventh day and the firstand the seventh day of the Barthel Index score.Results: Of the 30 subjects, there is a meaningful difference in average d-dimer’s value on the first dayof hospital admission and the seventh day (p<0.05). There are meaningful differences Barthel indexscore on the first day of hospital admission and the seventh day (p<0.05). There is a negative lowcorrelation d-dimer’s value on the first day with the Barthel Index score on the first day (r=-0.383;p<0.05).There are negative medium correlations of d-dimer’s value of the seventh day with the Barthel Indexscore on the seventh day (r=-0.576; p<0.05).Conclusion: There’s a negative correlation between d-dimer’s value with Barthel Index score in strokeischemic patientsKeywords: d-dimer, clinical outcome, Barthel Index, ischemic stroke