The Role of Bamboo Shoot Gigantochloa apus Extract in Decreasing MDA and Increasing IL-10 at The Atherosclerosis

Edy Soesanto (Department of Nursing, Muhammadiyah University of Semarang)
Edi Dharmana (Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University)
Soeharyo Hadisaputro (Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University)
Siti Fatimah Muis (Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University)

Health Notions
Vol 3, No 1 (2019): January

Introduction: Bamboo shoot Gigantochloa apus extract has antioxidant compounds that act as lipid peroxidation inhibitors and reduce free radical formation so that it can be used as an anti-inflammatory and anti-oxidative stress in the atherosclerosis. Aim: Knowing the effect of bamboo shoot Gigantochloa apus extract in reducing MDA levels and IL-10 increasing levels in rabbits given atherogenic diet. Methods: This experiment used randomized pre-test and post-test with control group design, in 24 New Zealand White rabbits divided into 4 groups randomly. MDA and IL-10 levels were examined by the ELISA method. Results and conclusion: Bamboo shoot Gigantochloa apus extract can reduce MDA levels and increase IL-10 levels significantly in accordance with increasing doses. The increase of MDA levels in the control group with all treatment groups was different (p = 0.0001), and between the treatment groups and other treatment groups there were also differences (p