<![CDATA[Objective: To compare diagnostic performance of International
Ovarian Tumor Analysis (IOTA) scoring method with Risk of Malignancy
Index-4 (RMI-4) and Sassone Morphology Index to predict
ovarian malignancy preoperatively.
Method: Retrospective study with 119 subject who underwent surgical
removal of ovarian tumor and performed histopathological
examination at Dr. Cipto Mangunkusumo Hospital on January to
December 2013. Demographic status, ultrasound scans, CA-125
level and histopathological result were collected to calculate the
score of each method. Sensitivity, specificity, positive predictive
value, negative predictive value and accuracy were calculated by
comparing each score with histopathology result. Comparison of
diagnostic performance was analyzed by ROC curve.
Result: There were 51.26% subjects with benign tumor and 48.74%
subjects with malignant tumor. Result was analyzed with sensitivity
test (IOTA simple-rules, IOTA subgroup, RMI-4 and Sassone): 98%,
88%, 86% and 79%; specificity: 74%, 67%, 61% and 89%; positive
predictive value: 78%, 72%, 68% and 87%; negative predictive
value: 98%, 85%, 82% and 81%; and accuracy: 86%, 77%, 73% and
84%. AUC value for IOTA simple-rules, IOTA subgroup, RMI-4 and
Sassone were: 0.86, 0.78, 0.73 and 0.84. Comparison of these results
were significant with p = 0.000.
Conclusion: IOTA simple-rules had better sensitivity, negative predictive
value and accuracy than IOTA subgroup, RMI-4 and Sassone
morphology index to predict ovarian malignancy preoperatively.
[Indones J Obstet Gynecol 2016; 1: 42-46]
Keywords: iota, ovarian neoplasm, risk of malignancy, scoring]]>
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