A1298C Polymorphism of Fetal Methylenetetrahydrofolate Reductase (MTHFR) Gene as a Risk Factor for Spontaneous Abortion

Sulfiana, Isah
T Chalid, St Maisuri
Farid, Retno B
Rauf, Syahrul
Hartono, Eddy

Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume. 4, No. 2, April 2016

Objective: To investigate the role of A1298C polymorphism of fetal
methylenetetrahydrofolate reductase (MTHFR) gene in spontaneous
abortion.
Method: The case control study design recruited 96 subjects in Siti
Fatimah and Pertiwi mother and child hospital, Dr. Wahidin Sudirohusodo,
Pelamonia, Bhayangkara, Syekh Yusuf, Haji and Labuang
Baji hospital from March to September 2014. All subjects fulfilling
the inclusion criteria were taken tissue samples from mothers experiencing
spontaneous abortion and blood samples from normally
born baby. The data were analyzed using Pearson chi-square with
significant rate of 5% (p