Studies on the Controlled Release of Drugs from Magnetic Nanobiocomposites

Thomas Heinze (Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena Humboldstraße 10 D-07743 Jena, Germany)
Robert Müller (Leibniz-Institute of Photonic Technology (IPHT), P.O.B 100239, D-07702 Jena, Germany)
Mengbo Zhou (Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena Humboldstraße 10 D-07743 Jena, Germany)
Martin Rabel (Department of Pharmaceutical Technology, Friedrich Schiller University of Jena, Otto-Schott-Straße 41, D-07745 Jena, Germany)
Paul Warncke (Institut für Pharmazie der Friedrich-Schiller-Universität Jena Otto-Schott-Straße 41, 07745 Jena)
Dagmar Fischer (Institut für Pharmazie der Friedrich-Schiller-Universität Jena Otto-Schott-Straße 41, 07745 Jena)

IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)
Vol 4, No 1 (2019): February 2019

Magnetic nanocomposites are a class of smart materials that have attracted recent interest as drug delivery systems or as medical implants. In this study, meltable nanobiocomposites (NBC) composed of biocompatible dextran fatty acid ester and magnetic nanoparticles (MNPs) melting close to human body temperature were prepared and loaded with Rhodamine B (RhB) or green fluorescent protein (GFP) as model drugs to evaluate their potential use as drug delivery system. The release of the model drugs from the magnetic NBC investigated under the influence of a high frequent alternating magnetic field (AMF, 20 kA/m at 400 kHz) showed that on-demand release is realized applying the external AMF. The NBC showed a long-term stability (28 d) of the incorporated iron oxide particles after incubation in artificial body fluids. This work reveals the potential of the NBC as a drug carrier.