Jurnal Ilmu Kefarmasian Indonesia
Vol 8 No 2 (2010): JIFI

Uji Aktivitas Sitotoksik dan Antioksidan Ekstrak Daun Keladi Tikus (T yphonium divaricatum (L) Decne)

YUNAHARA FARIDA (UNIVERSITAS PANCASILA)
TITIEK MARTATI (UNIVERSITAS PANCASILA)
AHMAD MUSIR (UNIVERSITAS PANCASILA)
BERNARD EDWARD (UNIVERSITAS PANCASILA)



Article Info

Publish Date
30 Sep 2010

Abstract

Cytotoxic and antioxidant activities of Typhonium divaricatum (L) Decne leaves extract have been explored. Preliminary phytocheinical screening on the extract were carried out for the compound`s profile. Biological activity was measured by using Brine Shrimp Lethality Test (BSLT), while cytotoxic activity was conducted on breast cancer cell line T-47D using MTT method, Antioxidant activity was measured by using DPPH free radical scavenging method. The results of phytochemical screening showed that the methanol extract contained Havonoid, saponin and steroid/triterpenoid compounds, meanwhile thc n-hexane extract contained steroid/triterpenoid compounds only. The highest biological activity was found in methanol extract (IC50 = 32.9 ppm). The highest cytotoxic activity was shown by n-hexane extract (IC50 = 32.50 ppm). The highest antioxidant activity using vitamin C as positive control was found in methanol extract (IC50 = 56.63 ppm). The preliminary results indicated that Typhonium divaricatum (L) Decne lcavcs is potential for anticancer and free radical scavenger.

Copyrights © 2010






Journal Info

Abbrev

jifi

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Description

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted ...