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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 21 Documents
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Search results for , issue "Vol 22, No 2 (2025)" : 21 Documents clear
Spray Gel Formulation of Goroho Banana (Musa acuminata L.) Peel Extract: Optimization and Wound Healing Activity Analysis Salainti, Madeleine Trisha; Yuliani, Sri Hartati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0011512

Abstract

Goroho banana (Musa acuminata L.) peel extract has been traditionally used in Minahasa for wound healing. This study aimed to develop and optimize a spray gel formulation containing Goroho banana peel extract and evaluate its wound healing activity. A factorial design was employed with two factors (Carbopol 940 and HPMC) at two levels. Preliminary testing determined 3% as the optimal extract concentration through wound healing evaluation in rats. Four spray gel formulations were developed and characterized for physicochemical properties, including viscosity, pH, and drying time. Results showed Formula B (Carbopol 0.5% and HPMC 0.6%) exhibited optimal characteristics with viscosity 223.8 ± 7.6 cPs, pH 5.13 ± 0.05, and drying time 4.22 ± 0.05 minutes. The HET-CAM irritation test revealed mild irritation scores (2.5-3.8) for all formulations, with Formula B showing the lowest score (2.5). Design Expert optimization generated 100 solutions, with the optimal formula containing Carbopol 0.670% and HPMC 0.517%. The wound healing activity showed no significant differences between spray gel formulations and Bioplacenton (p0.05), indicating comparable efficacy. This study demonstrates the successful development of a safe and effective spray gel formulation of Goroho banana peel extract for wound healing applications.

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