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INDONESIA
Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol. 64 No. 6 (2024): November 2024" : 13 Documents clear
Primary hypertriglyceridemia in children with familial chylomicronemia syndrome Jumantan, Dewi; Widowati, Titis; Hidayati, Irma Sri; Prawirohartono, Endy P.
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.546-50

Abstract

Hypertriglyceridemia can be caused by primary (genetic) or secondary etiology. One of the primary causes is hyperlipoproteinemia type I or known as familial chylomicronemia syndrome. Familial chylomicronemia syndrome is a rare autosomal recessive disease that occurs in 1-2 per 1,000,000 people, with specific characteristic signs, namely severe increment of fasting plasma triglyceride up to 100 times the normal value (about 1500-15,000 mg/dl) caused by lipoprotein lipase (LPL) mutation.
Successful management of a 7-year-old-female with juvenile dermatomyositis at a tertiary hospital in low-income country Wulandari, Desy; Lubis, Azwin Mengindra Putera; Hikmah, Zahrah; Endaryanto, Anang
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.551-8

Abstract

Juvenile dermatomyositis (JDM) is a rare chronic autoimmune disease belonging to idiopathic inflammatory myopathies. Pathological skin lesions and proximal weakness primarily characterize this entity, but clinical symptoms can be heterogeneous. Children are more likely to have long-term complications such as lipodystrophy, calcinosis, and vasculopathy. Calcinosis is one of the characteristic sequelae of JDM, despite recent advances in the treatment of JDM, about one-third of patients still develop dystrophic calcinosis. In low-income countries, the availability of medicines is very limited. In our case, a 7-year-old female diagnosed with JDM presented with calcinosis. Aggressive and adequate treatment with steroids, methotrexate, hydroxychloroquine, and aluminium hydroxide can treat the complications. It is challenging to establish an early diagnosis, treatment, prevention of long-term complications, and improved prognosis of JDM, which then will improve the patient’s quality of life, especially in low income countries with limited drug availability.
Kniest dysplasia in girl aged 4 years: a case report Sahoo, Ipsita; Jena, Nitish; Dash, Mrutunjay; Bisoi, Swarup
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.559-62

Abstract

Kniest dysplasia is a rare chondrodysplasia characterized by distinct musculoskeletal and craniofacial abnormalities. Additional features like hearing loss and some ocular abnormalities can also be present. We report a case of Kniest dysplasia from eastern India with a rare mutation confirmed by genetic testing. A 4-year-old girl presented with skeletal deformities with normal intelligence. On examination, she had dysmorphism, short stature, barrel-shaped chest, scoliosis, short limbs with enlarged joints, and dental problems. The skeletal survey showed platyspondyly, epiphyseal enlargement, and a hypoplastic femoral head with cloud-like calcification. Clinical suspicion of Kniest dysplasia was kept based on characteristic skeletal abnormalities and radiological findings. The diagnosis was confirmed by genetic analysis, which revealed a mutation in the COL2A1 gene (c.905C>T) on chromosome 12 exon 14.
Bone turnover markers and bone mineral density in prepubertal obese children: Bone health in prepubertal childhood obesity Taha, Ola; Elhwary, Amany; Shoeib, Sarah M.; Rashad, Yosra Fouad Mohammed; Ata, Dina
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.473-82

Abstract

Background Growing evidence suggests that childhood obesity has an impact on bone metabolism. Its entails of bone resorption, destruction of mature mineralized bone by osteoclasts followed by ossification, bone formation by osteoblasts, to maintain the dynamic nature of bone. Serum C-telopeptide of collagen cross-links (CTX) is considered a bone resorption marker while serum procollagen type I N-propeptide (PINP) is considered abone formation marker. Previous studies have reported the abnormality of these bone turnover marker in obese children. Objective To compare bone turnover markers and bone mineral density (BMD) in obese prepubertal children to those of normoweight children. Methods Bone metabolism was evaluated by measuring serum PINP as a bone formation marker and CTX level as a bone resorption marker by enzyme-linked immunosorbent assay. We used dual-energy X-ray absorptiometry (DEXA) scan to evaluate BMD in 60 prepubertal children with obesity and 30 healthy prepubertal normoweight children. Results The CTX was significantly higher in the case group compared to the control group (P=0.001). The case group also had significantly lower mean BMD (P=0.001) and BMD Z-score (P=0.001). C-telopeptide of collagen cross-links in the case group had significant positive correlations with waist circumference (P=0.001), BMI (P=0.001), and BMI Z-score (P=0.001). Significant negative correlations were found between waist circumference, BMI, and BMI Z-score with procollagen type I N-terminal propeptide, BMD, and BMD Z-score. Conclusion Obesity has a negative impact on bone health. Low BMD was associated with high CTX in prepubertal obese children.
Virtual learning due to covid-19 pandemic and body weight changes in children aged 6-12 years Aulia, Nadhira Haliza; Santoso, Andintia Aisyah; Ramadhanty, Mutiara; Wirawan, Bintang; Soesanti, Frida
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.509-16

Abstract

Background The COVID-19 pandemic has led to school closures and virtual learning implementation. The situation has affected children's lifestyles and created an obesogenic environment. Objective To evaluate the impact of virtual learning during the pandemic on body weight changes in children. Methods This cross-sectional study was conducted on 6-12 years age children who experienced virtual school learning in Jakarta, Indonesia. Parents or guardians were asked to complete an online questionnaire about lifestyle changes and children's anthropometric data both before and during the virtual learning period. Changes in the weight-for-age Z-score (WAZ) and BMI Z-score (BMIZ) were analyzed using the Wilcoxon signed-rank test. Results A total of 206 children were assessed. There was a significant relation between virtual learning due to the COVID-19 pandemic and WAZ and BMIZ changes among children aged 6-12 years. Approximately 64% of the children experienced WAZ decrement (P value = 0.000), and 77.1% experienced BMIZ decrement (P value = 0.000). Conclusion This study do not align with existing studies' indicating that the pandemic lead to weight gain in children. Instead, the results shows that virtual learning period causes both WAZ and BMIZ to decrease.
Exclusive breastfeeding for 6 months is associated with reduced risk of febrile seizure Gosal, Jessica; Suryawan, I Wayan Bikin; Indrawan, I Gde Doddy Kurnia
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.463-8

Abstract

Background Febrile seizure (FS) is the most common convulsion disorder without an intracranial abnormality in children aged 6 months to 5 years. Risk factors for FS vary from maternal illness during pregnancy to pediatric nutritional factors, such as micronutrient deficiency or history of exclusive breastfeeding (EBF). The WHO recommends breastfeeding for up to 6 months because breastmilk contains numerous protective factors that may influence immune system development. Objective To analyze the relationship between FS and EBF and other potential risk factors in children aged 6-60 months. Methods This paired case-control study used patient medical record data from Wangaya Hospital, Denpasar from 2019-2020. Subjects were included by a purposive sampling technique, matched by age group. Children aged 6 to 60 months with fever >38oC and seizures were allocated to the case group; those with fever but without seizures were allocated to the control group. Patients with intracranial disorders, born prematurely, or with incomplete medical record data were excluded. Data were analyzed using McNemar test, with P values <0.05 deemed to be statistically significant. Results Of 92 participants, 46 children were allocated into each group. There were no significant differences of gender, delivery method, or birth weight between the case and control groups. Febrile seizure was significantly greater in subjects with a family history of all seizures, overweight nutritional status, and who were non-EBF. McNemar analysis showed that EBF children had significantly lower risk of FS compared to non-EBF children (OR 0.74; 95%CI 0.15 to 3.55; P=0.017). Additionally, positive family history of FS was also a significant factor (OR 4.33; 95% CI 0.25 to 76.04; P=0.021), but not with the overweight nutritional status. Conclusion Exclusive breastfeeding are associated with reduced risk of FS in children aged 6 months to 5 years.
Treatment duration and dosage of valproic acid and subclinical hypothyroidism incidence in pediatric epilepsy patients Carolina, Infra Yunita; Anidar, Anidar; Andid, Rusdi; Yusuf, Sulaiman; Darussalam, Dora; Sovira, Nora
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.469-72

Abstract

Background Epilepsy is a central nervous system disorder characterized by abnormal electrical activity in the brain.1 Prolonged administration of valproic acid at therapeutic doses can disrupt thyroid function, leading to subclinical hypothyroidism. This condition is marked by elevated thyroid stimulating hormone (TSH) levels, with normal serum free T4 (FT4) levels.2 Objective To investigate for possible associations between valproic acid therapy duration and dosage with the incidence of subclinical hypothyroidism in pediatric epilepsy patients. Methods This analytical, cross-sectional study included children aged 4 months to 18 years treated at the Pediatric Clinic of RSUD Dr. Zainoel Abidin, Banda Aceh, from September to November 2023. Subjects diagnosed with epilepsy and treated with valproic acid for at least 3 months were included in this study and underwent FT4 and TSH examinations. Results Forty-four children met the study criteria. Subclinical hypothyroidism occurred in 5 (11.4%) subjects during valproic acid therapy. Chi-square analysis revealed no significant association between therapy duration ?1 year (OR 1.286; 95%CI 0.193 to 8.568; P=1.00) or therapy dose ?20-40 mg/kg/day (OR 3.429; 95%CI 0.351 to 33.518; P=0.37) with subclinical hypothyroidism incidence. Conclusion Neither the duration nor the dosage of valproic acid therapy were significantly associated with the incidence of subclinical hypothyroidism in children with epilepsy.
Cord blood iron status and vitamin D concentration in newborns of anemic and non-anemic mothers in Makassar, Indonesia Ridha, Nadirah Rasyid; Massi, Muhammad Nasrum; Fikri, Bahrul; Putri, Sri Hardiyanti; Hidayah, Najdah; Arsyad, Andi Fatimah
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.483-9

Abstract

Background Iron deficiency (ID) is a common micronutrient problem, especially in pregnant women in developing countries such as Indonesia. Moreover, vitamin D deficiency is also a major concern in worldwide public health. A correlation between anemia, ID, and vitamin D deficiency in children has been identified, but investigations in pregnant women and their newborn babies are still limited. Objective To assess association between iron status and vitamin D levels in umbilical cord blood and maternal anemia. Methods This cross-sectional study involved 109 pregnant women and their newborns. They were divided into two groups, with and without maternal anemia. Collected cord blood (2 mL) was placed in tubes with ethylenediaminetetraacetic acid (EDTA). Plasma ferritin and vitamin D (25-hydroxyvitamin D, 25(OH)D) levels were measured by enzyme-linked immunosorbent assay (ELISA). Results Maternal anemia was found in 60 mothers (55% subjects). The mean cord blood hemoglobin levels for the anemic and non-anemic groups were 15.19 (SD 2.25) g/dL and 15.12 (SD 1.98) g/dL, respectively (P=0.87). Median cord blood ferritin levels were slightly lower in anemic [12.95 (range 0.42-17.69) µg/L] than in non-anemic mothers[13.45 (range 7.10-22.12) µg/L], but were not significantly different (P=0.555). Median cord blood 25(OH)D levels were lower in the anemic group [12.24 (range 8.53-32.99) ng/dL] than in the non-anemic group [14.26 (range 9.84-61.44) ng/dL], but the difference was not significant (P=0.964). Conclusion Maternal anemia was not significantly associated with cord blood hemoglobin, ferritin, or 25(OH)D levels.
Comparing clinical, laboratory, and epidemiological features of COVID-19 variants during different pandemic waves among children in Ukraine Harashchenko, Tetiana; Umanets, Tetiana; Livshits, Ludmila; Volodymyr, Lapshyn; Antypkin, Yurii
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.517-26

Abstract

Background The SARS-CoV-2 virus, the causative agent of the coronavirus disease (COVID-19), mutated during its replica-tion and spread among the population. These mutations led to new viral variants, which differed in their characteristics and manifestations, contributing to the wave-like progression of the COVID-19. The Centers for Disease Control and Prevention classified variants based on the public health risk include variants of interest such as λ and μ, variants of concern including α, β, γ, δ, ο, variants of high consequence, and variants being monitored. Objective To conduct a comparative analysis of the demographic, clinical, epidemiological, radiological, and laboratory character-istics of hospitalized children with COVID-19 during different waves of the disease. Methods A cohort study was conducted involved 337 children aged one month to 18 years who were hospitalized with laboratory-confirmed COVID-19 between 2020 and 2023 in Ukraine. Results During wave 3 (W3), wave 5 (W5) and wave 6 (W6), children under 3 years of age were hospitalized more frequently. The severe course of disease predominantly occurred during W3 period, with 47.3% cases demonstrating severe symptoms such as respiratory failure, bilateral pneumonia, and significant changes in laboratory parameters, including white blood cell count, eryth-rocyte sedimentation rate, D-dimer, and procalcitonin. One fatal case was reported during W3. The duration of hospitalization was longest for children in the W3 group. A moderate course of the disease was significantly more prevalent among hospitalized children in the first wave (77.78%, P<0.05), characterized by interstitial changes in the lungs, elevated C-reactive protein, and platelet levels. Fever and intoxication syndrome were reported with similar frequency during all waves of COVID-19. Conclusion Our study demonstrates the dynamic changes in manifestations and the progression of the disease across different variants of concern of SARS-CoV-2. The most severe cases of COVID-19 was observed during the third wave which predominated by the δ (delta) strain.
Improving stunting prevention program through community healthcare workers training and home-based growth monitoring: A quality improvement model Miranda, Adriana Viola; Nugraha, Ryan Rachmad; Sirmareza, Trio; Rastuti, Maritta; Asmara, Rindang; Astuti, Sri Puji; Nasytha, Safarah Risvie; Petersen, Zack
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.536-45

Abstract

Background Over 1.5 million community healthcare workers (CHWs) work in pos pelayanan terpadu (posyandu) in Indonesia. They are in charge of growth monitoring and counseling, as part of a community-based stunting prevention program. Recent literature suggests that the program requires quality improvements to maximize its potential. Objective To understand the impacts of a quality improvement model comprising capacity building for CHWs and home-based growth monitoring using smart charts on posyandu performance, particularly related on its stunting prevention components. Methods This cross-sectional study was conducted in two rural villages in Lombok, Indonesia in May 2023. We interviewed 130 CHWs and 317 mothers with children under-five with a pre-validated questionnaire on posyandu performance that was developed using an input-process-output framework. We evaluated the CHWs dan mothers performances in the height measurement and counseling process. Results Both CHWs and mothers perceived performance improvements in the height measurement and counseling processes, with statistically significant differences between pre- and post-intervention performance scores for height measurement [mean differences of 0.38 points; 95%CI 0.188 to 0.566; P<0.000 (CHWs) and 0.276 points; 95%CI 0.469 to 0.846; P<0.000 (mothers)]; for counseling [mean differences of 0.285 points; 95%CI 0.149 to 0.42; P<0.001 (CHWs) and 0.142 points; 95%CI 0.098 to 0.186; P<0.000 (mothers)]. Performance improvements were also found across all posyandu components, including those related to stunting. Conclusion Capacity building for CHWs and home-based growth monitoring using smart charts are beneficial in improving community-based stunting prevention programs.

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