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Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol. 66 No. 1 (2026): January 2026" : 5 Documents clear
Leukoreduction therapy in pediatric malignant pertussis: a systematic review Wijaya, Melati; Ihsan, Indra; Mariko, Rinang
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background Malignant pertussis (MP) in children is a severe form of pertussis characterized by hyperleukocytosis, which can be life-threatening and requires appropriate treatment to reduce mortality. Objective To review the effectiveness of available leukoreduction therapy modalities for pediatric MP. Methods A systematic literature review was performed in adherence to PRISMA guidelines. We searched MEDLINE (PubMed), Google Scholar, and ScienceDirect and included studies in English published from 2005 to 2025 which involved leukoreduction modalities such as exchange transfusion (ET), leukapheresis, extracorporeal membrane oxygenation (ECMO) with leukofiltration (ECMO-LF), and hydroxyurea (HU) plus supportive care on children aged 0-5 years with MP. Results Twenty articles were identified involving 241 cases of MP. The median age was 2 (range 0.4-19) months. White blood cell (WBC) reduction was 67-74% with ET (n=92), 65.2% with leukapheresis (n=6), 83% with ECMO-LF (n=5), and 23-70% with HU (n=9). In contrast to the other modalities, HU provided gradual reduction. Survival was significantly higher in the leukoreduction group (52.7%) compared to the non-leukoreduction group (32.6%) (P<0.01). WBC-stratified subgroup analysis demonstrated that patients with WBC ≥70,000/mm³ had a lower survival rate than those with WBC>50,000 to <70,000/mm³ (47.2% vs. 60.0%; P=0.048). Among patients with WBC ≥70,000/mm³, leukoreduction provided higher survival than did supportive care (55.2% vs. 14.3%; P=0.031; NNT=2.4). No significant difference in survival was observed in those with WBC >50,000/mm3 to <70,000/mm³ receiving leukoreduction vs. supportive care (57.1% vs. 66.7%; P=0.626). Conclusion Early identification of mortality risk factors and prompt management prior to organ dysfunction are essential for reducing mortality. Leukoreduction therapy should be considered for patients with WBC ≥70,000/mm³. Hydroxyurea may serve as an alternative non-invasive therapeutic option.
Prevalence and associated factors of infantile colic in infants of mothers in medical residency program Muzal Kadim; Wira Febrisandi Irsan; Tjhin Wiguna; Dina Muktiarti; Sulaiman Yusuf; Ade Rachmat Yudianto; Yusri Dianne Jurnalis; Yudith Setiati Ermaya; Wahyu Damayanti; Andy Dharma; Christy Venada
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background  Infantile colic, defined according to the Rome IV criteria as excessive crying in otherwise healthy infants without signs of illness or failure to thrive, could be linked to inadequate mother–infant bonding. The risk of infantile colic is increased in mothers with depression and insufficient family support. Infantile colic could lead to recurrent emergency department admissions, unnecessary treatments, and child abuse. Mothers in medical residency programs who often face long working hours, reduced bonding time with their infants, burnout, and depression, may be at an increased risk of having infants with colic. However, data on the prevalence and associated factors of infantile colic in infants of mothers in this specific population are lacking. Objective To determine the prevalence of infantile colic and its associated factors among infants of mothers participating in medical residency programs. Methods We conducted a cross-sectional study involving 67 infants of mothers in medical residency programs across seven centers in Java and Sumatra. We used the Indonesian-translated Parent Report Questionnaire for Children Aged 0-3 Years from the Rome Foundation to obtain information on infantile colic based on Rome IV criteria and the Indonesian version of the Mother-Infant Bonding Scale Questionnaire to assess the risk level of mother-infant bonding problems. An online questionnaire was distributed to subjects’ mothers via WhatsApp© application. Results  Of 67 subjects, 18 (26.8%) experienced infantile colic. High risk of mother–infant bonding problems, as indicated by elevated Mother-Infant Bonding Scale-Indonesian version (MIBS-I) scores, were significantly associated with infantile colic (OR 2.922; 95%CI 1.07 to 4.87; P=0.046). The type of nutrition, whether breast milk or a combination of formula and breast milk, did not significantly differ between infants with and without colic (OR 1.333; 95%CI 0.451 to 3.940; P=0.602). Conclusion Elevated MIBS-I scores, reflecting impaired mother–infant bonding, are ssociated with an increased risk of infantile colic in infants born to mothers in medical residency training programs.
Vitamin D deficiency in newborns: a tropical paradox Dewanto, Naomi Esthernita F.; Santi, Theresia; Sugiri, Zaneth; Napitupulu, Nancy; Jo, Juandy
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background  Previous studies have shown a 'tropical paradox' in Indonesia, where despite being a tropical country with abundant sunlight, a widespread vitamin D inadequacy is observed in various populations. This paradox extends to Indonesian children, who predominantly exhibit low vitamin D levels, yet research specifically investigating vitamin D status in the newborn remains notably limited. Objective To determine the prevalence of low level of vitamin D and elucidate its correlation with the conditions of newborns in Jakarta, Indonesia. Methods This retrospective study analyzed data from newborns undergoing assessment at Siloam Hospital Kebon Jeruk, Jakarta, from June 2022 to May 2024. We collected the following data: newborn’s vitamin D level, demographic and clinical characteristics, as well as available maternal data. Serum 25-hydroxyvitamin D [25(OH)D] levels between < 20, 20–29.9 and ≥ 30 ng/mL were classified as deficient, insufficient, and sufficient, respectively. Statistical analyses were used to compare baseline characteristics and outcomes based on vitamin D status. Results Of the 243 newborns studied, 70.4% were classified as vitamin D deficient, 22.2% as insufficient, and 7.4% as sufficient. Subjects’ median vitamin D level was 15.7 (range 1.2 – 57.1)  ng/mL. No significant difference in vitamin D levels was observed between male and female newborns (p=0.190) and between newborns with birthweight < 2,500 and the ones with birth weight ≥2,500 grams (p=0.794). Vitamin D levels were not significantly different between healthy and sick newborns (p=0.537). Maternal vitamin D status was available for only a small proportion (15.6%) of mothers, highlighting the need for further investigation into maternal-newborn vitamin D status. Conclusion Although a high prevalence of newborn with vitamin D deficiency was observed in our study participants, no significant difference in vitamin D levels was observed between healthy and sick newborns. No correlation was observed between sex or birth weight, and vitamin D levels as well. Future inquiries should explore maternal vitamin D status in greater detail and assess the prolonged health consequences of hypovitaminosis D in newborns.  
Dobutamine and cardiac index change in fluid-refractory children with septic shock Mejestha Rouli Puspitasari; Dewi Ratih Priyantiningsih; Adhie Nur Radityo
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background  Sepsis became the main cause of morbidity and mortality in children globally. The mortality rate was 18-46% in developing countries. The primary goal of septic shock resuscitation was to achieve adequate cardiac output (CO), which 18% responded to fluid resuscitation and needed vasoactive therapy. Dobutamine as inotrope and vasodilator agent could increase CO that measured by cardiac index (CI). Its heterogeneity variance response was influenced by many factors. Objective To analyze the effectiveness of dobutamine administration at 5 mcg/kg/minute on CI change in fluid-refractory children with septic shock and identify factors to improve outcomes in children with septic shock. Methods This pretest and posttest study included 50 children aged 1 month to < 18 years who were diagnosed with fluid-refractory septic shock and admitted to the pediatric intensive care unit (PICU) at Dr. Kariadi Hospital, Semarang, during the period of January 2022 to December 2023. The CI, corrected flow time (FTc) (preload), Smith-Madigan inotrophy index (SMII) (contractility), and systemic vascular resistance index (SVRI) (afterload) parameters were measured by an ultrasonic cardiac output monitor (USCOM) before and after dobutamine administration at 5 mcg/kg/minute. T-paired and Chi-square tests were used to analyze data. Results After dobutamine administration at 5 mcg/kg/minute, CI increased in 54% of subjects, with mean delta of 0.45 (SD 1.17 L/min/m2; P: 0.008) and low SMII was associated with an increased CI (PR: 8.944 (95%CI: 2.314 to 34.581; P:  0.001). Age, sex, nutritional status, anemia, acute kidney injury, total fluid resuscitation, FTc, and SVRI did not significantly affect CI change. Conclusion Dobutamine at 5 mcg/kg/minute had an effect of increasing CI, especially in patients with low SMII in fluid-refractory septic shock.
Clinical characteristics and genetic mutations in hemophilia A patients with inhibitors Primacakti, Fitri; Wahidiyat, Pustika Amalia; Sjarif, Damayanti Rusli; Chozie, Novie Amelia; Sukartini, Ninik; Prihartono, Joedo; Salsabila, Sheila Claudhea; Ramadhani, Nadhifa Tazkia; Lubis, Bidasari
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background Antibodies to factor VIII, known as inhibitors, are a major problem in hemophilia A, especially in severe cases. Certain genetic mutations are associated with a higher risk of the formation of inhibitors. This study is the first in Indonesia to report on genetic mutations of hemophilia A patients with inhibitors. Objectives To detect genetic mutations, investigate potential risk factors, and evaluate inhibitor prevalence in pediatric hemophilia A patients. Methods An observational study was conducted at the Pediatric Hemophilia Treatment Center of Cipto Mangunkusumo Hospital, Jakarta. Inhibitors were measured using the Bethesda assay and classified as low- or high titer. Inverse shifting polymerase chain reaction (IS-PCR) was performed to detect inversion mutations. Negative results for inversion were followed by Sanger sequencing. Clinical data were obtained from medical records. Results Inhibitors were detected in 17 of 114 hemophilia A patients (14.9%), most of whom (88.2%) had severe disease and had fewer than 150 days of exposure to clotting factor concentrates (CFCs), classifying them as previously untreated patients (PUPs). The genetic mutations identified in inhibitor patients were intron 22 inversion (INV-22) mutations (41.2%), intron 1 inversion (INV-1) mutations (29.4%), nonsense mutations (17.6%), large deletions (5.9%), and missense mutations (5.9%). Family history of inhibitors, previous intensive treatment for major bleeding events or surgery, and type of concentrate were potential risk factors. Conclusion Intron 22 inversion mutations were the most common mutations associated with the presence of inhibitors in hemophilia A patients.

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