cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Roni Koneri
Contact Email
ronicaniago@unsrat.ac.id
Phone
+6281340275276
Journal Mail Official
j.bioslogos@gmail.com
Editorial Address
Jurusan Biologi FMIPA Universitas Sam Ratulangi
Location
Kota manado,
Sulawesi utara
INDONESIA
Jurnal Bios Logos
Published by Universitas Sam Ratulangi
ISSN : 20889569     EISSN : 26563282     DOI : https://doi.org/10.35799/jbl.11.2.2020.28153
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
JURNAL BIOS LOGOS is the journal published by Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The aims of the journal are to publish original research papers and article review in biology science i.e. botany, zoology, molecular biology, microbiology, ecology, diversity and conservation, taxonomy and biogeography. BIOS LOGOS is published two times per year (February and August)
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 11 Documents
 1   2 
Search results for , issue "Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS" : 11 Documents clear
Identification of Potential PDE5 Inhibitors from Natural Sources for Erectile Dysfunction Therapy Through A Molecular Docking Approach Mantiri, Vic; Tendean, Lydia; Turalaki, Grace
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.66648

Abstract

The global prevalence of erectile dysfunction has increased in recent decades, and despite various treatment modalities, including phosphodiesterase-5 (PDE5) inhibitors, side effects and contraindications necessitate alternative therapies. This research explores the potential of active compounds present in aphrodisiac plants as PDE5 inhibitors using a molecular docking approach. Eight test compounds evaluated, namely quercitrin, quercetin, garcinoic acid, ellagic acid, catechin, and kaempferol, exhibited high affinity towards PDE5. Receptor-ligand analysis revealed interacting residues supporting PDE5 inhibition. Pharmacokinetic analysis demonstrated similarities, particularly in terms of bioavailability and toxicity, among these ligands, except for quercitrin when compared to the control ligand, sildenafil. This study found that compounds derived from herbal sources show potential as PDE5 inhibitors, with pharmacokinetic profiles comparable to sildenafil. Experimental validation is required to verify the efficacy of these ligands.

Page 2 of 2 | Total Record : 11

 1   2 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS Vol. 15 No. 2 (2025): JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS Vol. 14 No. 3 (2024): JURNAL BIOS LOGOS Vol. 14 No. 2 (2024): JURNAL BIOS LOGOS Vol. 14 No. 1 (2024): JURNAL BIOS LOGOS Vol. 13 No. 3 (2023): JURNAL BIOS LOGOS Vol. 13 No. 2 (2023): JURNAL BIOS LOGOS Vol. 13 No. 1 (2023): JURNAL BIOS LOGOS Vol. 12 No. 2 (2022): JURNAL BIOS LOGOS Vol. 12 No. 1 (2022): JURNAL BIOS LOGOS Vol. 11 No. 2 (2021): JURNAL BIOS LOGOS Vol 11, No 2 (2021): JURNAL BIOS LOGOS Vol 11, No 1 (2021): JURNAL BIOS LOGOS Vol. 10 No. 2 (2020): JURNAL BIOS LOGOS Vol 10, No 2 (2020): JURNAL BIOS LOGOS Vol 10, No 1 (2020): JURNAL BIOS LOGOS Vol 9, No 2 (2019): JURNAL BIOS LOGOS Vol 9, No 1 (2019): JURNAL BIOSLOGOS Vol 8, No 2 (2018): JURNAL BIOSLOGOS Vol 8, No 1 (2018): JURNAL BIOSLOGOS Vol 7, No 2 (2017): JURNAL BIOSLOGOS Vol 7, No 1 (2017): JURNAL BIOSLOGOS Vol 6, No 2 (2016): JURNAL BIOSLOGOS Vol 6, No 1 (2016): JURNAL BIOSLOGOS Vol 5, No 2 (2015): JURNAL BIOSLOGOS Vol 5, No 1 (2015): JURNAL BIOSLOGOS Vol 4, No 2 (2014): JURNAL BIOSLOGOS Vol 4, No 1 (2014): JURNAL BIOSLOGOS Vol 3, No 2 (2013): JURNAL BIOSLOGOS Vol 3, No 1 (2013): JURNAL BIOSLOGOS Vol 2, No 2 (2012): JURNAL BIOSLOGOS Vol 2, No 1 (2012): Jurnal Bioslogos Vol 1, No 1 (2011) More Issue