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Jurnal Bioteknologi & Biosains Indonesia (JBBI)

JBBI
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Published by Badan Pengkajian dan Penerapan Teknologi

ISSN : 24422606 EISSN : 2548611X DOI : -

Core Subject : Science, Agriculture,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

JBBI, Indonesian Journal of Biotechnology & Bioscience, is published twice annually and provide scientific publication medium for researchers, engineers, practitioners, academicians, and observers in the field related to biotechnology and bioscience. This journal accepts original papers, review articles, case studies, and short communications. The articles published are peer-reviewed by no less than two referees and cover various biotechnology subjects related to the field of agriculture, industry, health, environment, as well as life sciences in general. Initiated at the then Biotech Centre, the journal is published by the Laboratory for Biotechnology, the Agency for the Assessment and Application of Technology, BPPT.

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KEMAMPUAN EKSTRAK SENYAWA AKTIF BAKTERI ENDOFIT DALAM MENGHAMBAT PERTUMBUHAN Fusarium oxysporum f.sp. PADA KELAPA SAWIT Candrawati, Emilia; Rupaedah, Bedah; Sumpono, Sumpono; Sundaryono, Agus
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Ability of Active Compound Extract of Endophytic Bacteria to Inhibit the Growth of Fusarium oxysporum f.sp. in Oil PalmÃ‚Â ABSTRACTWilt vessels disease in oil palm plants is caused by Fusarium oxysporum f.sp. This disease is very harmful because of its ability to kill the infected oil palm plant in less than a year. Endophytic bacteria are likely to be biological controllers for the disease because of their ability to produce bioactive antifungal compounds. Isolation of endophytic bacteria from oil palm plant and activity test of their active compounds against F. oxysporum f.sp. in vitro had been done. Antagonistic test of endophytic bacterial isolates against F. oxysporum f.sp. was carried out using a double culture method. The potential endophytic bacterial isolates were extracted using ethyl acetate solvent for their active compounds, which were then tested for its activity in inhibiting the growth of F. oxysporum f.sp. The results showed that the active compound extract of B11 endophytic bacteria with the incubation time of 24 and 54 hours gave the growth inhibition of F. oxysporum f.sp. at the level of 29.23% and 43.85%, respectively.Keywords: antagonistic test, bioactive compound, endophytic bacteria, F. oxysporum f.sp., oil palmÃ‚Â ABSTRAKPenyakit layu pembuluh pada tanaman kelapa sawit disebabkan oleh Fusarium oxysporum f.sp. Penyakit ini menjadi penyebab kematian tanaman kelapa sawit yang telah terinfeksi dalam waktu kurang dari setahun. Bakteri endofit asal tanaman kelapa sawit dimungkinkan menjadi pengendali hayati bagi penyakit ini karena kemampuan bakteri tersebut memproduksi senyawa bioaktif yang bersifat antifungi. Isolasi bakteri endofit dari tanaman kelapa sawit dan uji aktivitas senyawa aktifnya terhadap F. oxysporum f.sp. secara in vitro telah dilakukan. Uji antagonis isolat bakteri endofit terhadap jamur patogen F. oxysporum f.sp. menggunakan metode kultur ganda. Isolat bakteri endofit potensial diekstrak senyawa aktifnya dengan menggunakan pelarut etil asetat, kemudian senyawa aktif ini diuji aktivitasnya dalam menghambat pertumbuhan jamur patogen F. oxysporum f.sp. Hasil penelitian menunjukkan bahwa ekstrak senyawa aktif bakteri endofit B11 dengan waktu inkubasi 24 dan 54 jam memberikan daya hambat terhadap F. oxysporum f.sp. sebesar masing-masing 29,23% dan 43,85%.Kata Kunci: bakteri endofit, F. oxysporum f.sp., kelapa sawit, senyawa aktif, uji antagonisÃ‚Â

DAMPAK TEKNIK PENGIRISAN DAN PENCETAKAN TERHADAP DAYA APUNG PAKAN IKAN YANG DIFERMENTASI MENGGUNAKAN Rhizopus sp. Suliswati, Lulu; Sriherwanto, Catur; Suja'i, Imam
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29122/jbbi.v5i2.3096

Impact of Slicing and Moulding Techniques on the Floatability ofÃ‚Â the Fish Feed Fermented by Rhizopus sp.ABSTRACTThe use of Rhizopus sp. mycelium as biocoating, biostabilizing, and biofloating agent in the production of floating fish feed through solid fermentation had already been studied as a much simpler alternative to mechanical extrusion. The fermented fish feed, however, had poor floatability in aerated water, probably due to structural damage during the size reduction process of the feed. Thus, this study used alternative size-reducing methods, namely slicing and moulding, to improve the floatability of the fermented feed. Other physical characteristics were also measured and compared to those of commercial sinking and floating fish feeds. Results showed that both the moulded and the sliced fermented-feeds had lower density as well as higher water stability, absorption capacity, floatability, and durability compared to those of the commercial sinking feed used as the fermentation substrate. The hydrophobicity of all the feeds tested were similar, however. The floatability of the fermented feeds obtained in this study was much higher than those of the previous studies.Ã‚Â Keywords: floatability, floating feed, sinking feed, water absorption, water stabilityABSTRAKPenggunaan miselium Rhizopus sp. sebagai pelapis permukaan, penstabil, dan pengapung hayati dalam pembuatan pakan ikan apung melalui fermentasi padat telah diteliti sebagai alternatif yang jauh lebih sederhana dibandingkan dengan metode ekstrusi mesin. Namun, pakan ikan fermentasi ini memiliki daya apung yang buruk dalam air bergelembung udara, yang mungkin disebabkan kerusakan struktural selama proses pengecilan ukuran pakan. Karenanya, penelitian ini menggunakan metode lain untuk mengecilkan ukuran, yakni pencetakan dan pengirisan, dalam rangka meningkatkan daya apung pakan yang difermentasi. Karakteristik fisik lainnya juga diukur dan dibandingkan dengan pakan ikan tenggelam dan terapung komersial. Hasil menunjukkan bahwa proses fermentasi serta metode pengecilan dimensi yang digunakan menghasilkan pakan yang memiliki massa jenis lebih rendah, serta stabilitas air, daya serap air, daya apung, serta ketahanan benturan lebih tinggi dibandingkan dengan pakan tenggelam komersial yang digunakan sebagai substrat fermentasi. Namun, nilai hidrofobisitas semua pakan yang diuji adalah sama. Daya apung pakan fermentasi dalam penelitian ini jauh lebih tinggi daripada penelitian sebelumnya.Kata Kunci: daya apung, daya serap air, stabilitas dalam air, pakan apung, pakan tenggelam

Back Cover JBBI Vol 5, No 2, December 2018 Sriherwanto, Catur
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

PENGARUH WADAH KULTUR DAN KONSENTRASI SUMBER KARBON PADA PERBANYAKAN KENTANG ATLANTIK SECARA IN VITRO Karyanti, Karyanti; Kristianto, Yosua Glen; Khairiyah, Hayat; Novita, Linda; Sukarnih, Tati; Rudiyana, Yayan; Sofia, Dewi Yustika
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

The Effect of Culture Container and Carbon Source Concentration on In Vitro Shoot Propagation of Atlantic PotatoABSTRACTPotato is a food commodity that has the potential to support food diversification in Indonesia. There is an increasing demand for Atlantic potatoes as the raw material for processed potato products. The demand, which has not been met by the increased production, has been the cause of the ongoing potato import activities in Indonesia. The limitation of producing quality Atlantic potato seeds economically is one of the obstacles to increasing the production of Atlantic potatoes in Indonesia. The aim of this research was to study the effect of various table sugar concentrations as the carbon source and the type of the culture containers used for Atlantic potato shoot multiplication in vitro. The propagation was carried out in bioreactors and culture bottles with MS liquid medium + coconut water at a concentration of 150 mL/L medium, and 3 concentration levels of table sugar, namely 0; 7.5; and 15 g/L medium. The use of bioreactor significantly increased the height of the Atlantic potato plantlets. The use of bioreactor combined with table sugar addition decreased hyperhydricity level. The highest number of shoots, leaves, and roots were found at the table sugar concentration of 15 g/L medium in both containers.Keywords: bioreactor, micropropagation, shoot culture, Solanum tuberosum, sucroseÃ‚Â ABSTRAKKentang merupakan komoditas pangan yang berpotensi mendukung program diversifikasi pangan di Indonesia. Peningkatan permintaan terhadap kentang Atlantik sebagai bahan baku kentang olahan yang tak diimbangi dengan peningkatan produksi kentang Atlantik menjadi penyebab masih berlangsungnya impor kentang Atlantik di Indonesia. Keterbatasan menghasilkan benih kentang Atlantik berkualitas yang ekonomis merupakan salah satu hambatan dalam meningkatkan produksi kentang Atlantik di Indonesia. Penelitian ini bertujuan mempelajari pengaruh variasi konsentrasi sukrosa teknis sebagai sumber karbon dan penggunaan jenis wadah terhadap perbanyakkan tunas kentang Atlantik secara in vitro. Perbanyakkan tunas kentang Atlantik menggunakan media MS cair + 150 mL/L air kelapa dalam wadah bioreaktor dan botol kultur dengan 3 taraf konsentrasi sukrosa, yaitu 0; 7,5; dan 15 g/L media. Penggunaan bioreaktor secara signifikan meningkatkan tinggi planlet kentang Atlantik yang dihasilkan. Penggunaan bioreaktor yang dikombinasikan dengan penambahan sukrosa teknis menurunkan tingkat hiperhidrisitas. Tunas, daun, dan akar terbanyak dihasilkan oleh perlakuan sukrosa teknis 15 g/L media dalam kedua jenis wadah.Kata Kunci: bioreaktor, kultur tunas, mikropropagasi, Solanum tuberosum, sukrosa

VARIASI GENETIK KAMBING BENGGALA DI KABUPATEN MANGGARAI BARAT BERDASARKAN METODE RANDOM AMPLIFIED POLYMORPHIC DNA Pakpahan, Suhendra; Artama, Wayan Tunas; Widayanti, Rini; Budisatria, I Gede Suparta
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Genetic Variation of Benggala Goats in West Manggarai Regency Based on Random Amplified Polymorphic DNA MethodÃ‚Â ABSTRACTIndonesia has several types of local goats that have had an extended period of adaptation to the natural conditions in Indonesia. Goat is one of the most important germplasm in supporting the economy of rural communities. Benggala is a local breed of goat originating from Flores Island, East Nusa Tenggara province and has distinctive characteristics. The RAPD technique has several advantages and has been widely used in studies of the genetic diversity of goats. A total of 50 blood samples of Benggala goats were taken from four sub-districts in West Manggarai Regency. This study was conducted to estimate genetic variations of Benggala goats using OPA-6 and OPA-16 primers. The OPA-6 primer consisted of 0-11 bands, while the OPA-16 primer consisted of 0-7 bands. The total bands produced on the OPA-6 primer from all samples was 456, whilst OPA-16 primer was 314. The lowest genetic similarity between individuals of Benggala goats was 44% from the sample K46. Based on the sample population, the average genetic similarity level was 72%. These results show that the genetic diversity of Benggala goats is low.Keywords: BenggalaÃ‚Â goat, genetic similarity,genetic variation, RAPD, West ManggaraiÃ‚Â ABSTRAKIndonesia memiliki beberapa jenis kambing lokal yang memiliki periode adaptasi yang panjang dengan kondisi alam di Indonesia. Kambing merupakan salah satu plasma nutfah yang sangat penting dalam mendukung perekonomian masyarakat pedesaan. Benggala adalah jenis kambing lokal yang berasal dari pulau Flores, propinsi Nusa Tenggara Timur dan kambing Benggala memiliki ciri khas. Teknik RAPD memiliki beberapa keunggulan dan telah banyak digunakan pada studi keragaman genetik kambing. Total 50 sampel darah kambing Benggala yang diambil dari empat kecamatan di Kabupaten Manggarai Barat. Penelitian ini dilakukan untuk menguji variasi genetik kambing Benggala dengan menggunakan primer OPA-6 dan OPA-16. Primer OPA-6 terdiri dari 0-11 band, sedangkan primer OPA-16 terdiri dari 0-7 band. Total jumlah pita yang dihasilkan pada primer OPA-6 dari semua sampel adalah 456, sementara primer OPA-16 adalah 314. Kemiripan genetik terendah antara individu-individu kambing Benggala adalah 44% dari sampel K46. Berdasarkan populasi sampel, tingkat kemiripan genetik rata-rata adalah 72%. Hasil ini menunjukkan bahwa keragaman genetik kambing Benggala tergolong rendah.Kata Kunci: kambing Benggala, kemiripan genetik, Manggarai Barat , RAPD, variasi genetik

IDENTIFIKASI AKTINOMISETES SEDIMEN AIR TAWAR MAMASA, SULAWESI BARAT DAN AKTIVITASNYA SEBAGAI ANTIBAKTERI DAN PELARUT FOSFAT Putri, Ade Lia; Lisdiyanti, Puspita; Kusmiati, Mia
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Identification of Actinomycetes in Freshwater Sediments from Mamasa, West Sulawesi and Their Antibacterial and Phosphate Solubilizing ActivitiesABSTRACTA large number of actinomycetes that have been isolated and screened were obtained from soil and marine samples. Consequently, the possibility of isolating novel Actinomycetes and secondary metabolites compounds strains from soil and marine samples have limited. Exploration of actinomycetes from freshwater sediment is rare. In this study, 30 isolates of Actinomycetes from freshwater sediments in Mamasa District, West Sulawesi were isolated, identified, and screened for their antibacterial and phosphate solubilizing activity. Actinomycetes were isolated by serial dilution method and were identified based on morphological and 16S rRNA gene sequence. Antibiotic activity was screened using the agar plug diffusion method, while soluble phosphate ability was observed by clear zone ratio in PKA medium. Most of the isolates belong to the genus Streptomyces (80%). Out of 30 isolates, 56.6% showed antibacterial activity and 36.6% had potential as solubilizing phosphate which belong to genus Streptomyces, Actinomadura, and Kitasatospora.Keywords: 16S rRNA, Actinomycetes, antibacterial, freshwater sediment, phosphate solubilizingÃ‚Â ABSTRAKSebagian besar aktinomisetes yang telah diisolasi dan dilakukan penapisan metabolit sekundernya berasal dari sampel tanah dan laut. Konsekuensinya, kesempatan untuk menemukan aktinomisetes jenis baru maupun yang menghasilkan metabolit sekunder baru dari tanah dan laut semakin berkurang. Eksplorasi aktinomisetes dari lingkungan lain seperti sedimen air tawar jarang dilakukan. Pada penelitian ini, 30 isolat aktinomisetes yang diisolasi dari sedimen air tawar di Kabupaten Mamasa, Sulawesi Barat, telah diidentifikasi dan dilakukan penapisan antibakteri dan kemampuan isolat dalam melarutkan fosfat. Aktinomisetes diisolasi dengan metode pengenceran secara langsung dan selanjutnya diidentifikasi secara morfologi dan molekular berdasarkan gen 16S rRNA. Metode yang digunakan dalam penapisan aktivitas antibakteri adalah agar plug diffusion method, sedangkan kemampuan aktinomisetes dalam melarutkan fosfat diuji dengan cara menumbuhkan isolat pada media PKA. Isolat yang paling banyak diisolasi termasuk ke dalam marga Streptomyces (80%). Dari 30 isolat, 56,6% isolat menunjukkan adanya aktivitas antibakteri dan 36,6% dari isolat berpotensi sebagai pelarut fosfat, yang termasuk ke dalam marga Streptomyces, Actinomadura, dan Kitasatospora.Kata Kunci: 16S rRNA, Aktinomisetes, sedimen air tawar, antibakteri, pelarut fosfat

Preface JBBI Vol 5, No 2, December 2018: Foreword and Acknowledgement Tajuddin, Teuku
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

PENINGKATAN AKTIVITAS LIPASE KAPANG LIMBAH KERNEL DAN NUT KELAPA SAWIT DENGAN RADIASI GAMA DAN ULTRAVIOLET Indriawan, Aris; Mangunwardoyo, Wibowo; Suhendar, Dadang; Siswodarsono, Trismilah
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Enhancement of Lipase Activity of Molds Isolated from Kernel and Nut Waste of Oil Palm with Gamma and Ultraviolet IrradiationABSTRACTMolds isolated from oil palm waste sampled from Malingping, Lebak, Banten, West Java have the potential for lipase production. This study aimed to increase the fungal lipase activity with gamma radiation and ultraviolet light (UV). NA and KC mold spores were exposed to various gamma radiation doses of 1, 2, 3 and 4 kGy. The best of these NA and KC resulted mutants were followed by ultraviolet mutations for 1, 2, 3, and 4 hours, at dose of 0.1 J/cm2, 254 nm, 20 cm. Lipase activity was tested by the Lindfield method. The results showed that gamma radiation affected the lipase activity of NA1kGy mutants (8.58 U/mL) and KC1 kGy (8.25 U/mL), each increased the lipase activity by 4.6% and 3.13% from the wild type, respectively. Mutations with ultraviolet had an effect on mutant lipase activity of KC4H 10U/mL and NA3H 9.25 U/mL, each increased the lipase activity by 25% and 15.63% from the wild type, respectively. Based on phenotypic and phylogenetic (28srRNA) approaches, a mold of KC had a 100% similarity with Aspergillus fumigatus strain RA204.Keywords: gamma radiation, KC mold, lipase, NA mold, ultraviolet lightÃ‚Â ABSTRAKKapang dari limbah kelapa sawit diisolasi dari Malingping, Lebak, Banten, Jawa Barat berpotensi untuk menghasilkan lipase. Penelitian ini betujuan meningkatkan aktivitas lipase kapang dengan radiasi sinar gama dan sinar ultraviolet (UV). Spora kapang NA dan KC dipaparkan pada berbagai radiasi gama dosis 1, 2, 3 dan 4 kGy. Hasil terbaik dari mutan NA dan KC dilanjutkan dengan mutasi ultraviolet dengan lama inkubasi 1, 2, 3, dan 4 jam, dosis 0,1 J/cm2, 254 nm, 20 cm. Aktivitas lipase diuji dengan metode Lindfield. Hasil penelitian menunjukkan bahwa radiasi gama berpengaruh pada aktivitas lipase mutan NA 1kGy 8,58 U/mL dan KC1 kGy 8,25 U/mL, masing-masing menaikkan aktivitas lipase sebesar 4,6% dan 3,13% dari wild type-nya. Hasil mutasi dengan ultraviolet berpengaruh pada aktivitas lipase mutan KC4H 10U/mL dan NA3H 9,25 U/mL, masing-masing menaikkan aktivitas lipase sebesar 25% dan 15,63% dari wild type-nya. Berdasarkan pendekatan fenotipik dan filogenetik (28s rRNA), isolat kapang kernel C memiliki similiaritas 100% dengan spesies Aspergillus fumigatus strain RA204.Kata Kunci: kapang KC, kapang NA, lipase, radiasi sinar gama, sinar ultraviolet

KERAGAMAN GENETIK 22 AKSESI PADI LOKAL TORAJA UTARA BERBASIS MARKA SIMPLE SEQUENCE REPEATS (SSR) Ladjao, Holy Ekklesia; Sjahril, Rinaldi; Riadi, Muh.
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Genetic Diversity of 22 Local Rice Accessions from North Toraja Based on Simple Sequence Repeats (SSR) MarkersABSTRACTOne way to explore the potential of local rice is by the characterization that could obtain genetic diversity of that plants. The aim of this study was to obtain the genetic diversity of 22 local rice accession from North Toraja. Twenty-two of local rice accessions from North Toraja were characterized by 30 SSR markers and using NTSYS pc 2.1 program to analyze genetic diversity. The results showed that twenty-six SSR markers that had been analyzed produced some alelles with a size between 106.75-311 bp, the average number of alleles were 3 and the polymorphism rate was 0.53. On coefficient genetic similarity at 0.38, the population formed three clusters. Cluster I and II were dominated by rice that had no hair on the tip of the grain and cluster III were dominated by rice that had hair on the tip of the grain. There were 105 opportunities to crossing between accessions when the genetic distance was above 0.7.Keywords: genetic diversity, local rice, North Toraja, polymorphism rate, SSR markersÃ‚Â ABSTRAKSalah satu cara untuk menggali potensi padi lokal adalah dengan karakterisasi. Dengan adanya kegiatan karakterisasi tersebut maka dapat diketahui bagaimana keragaman genetik dari suatu tanaman. Penelitian ini bertujuan untuk mengetahui keragaman genetik dari 22 aksesi padi lokal Toraja Utara. Duapuluh dua aksesi padi lokal Toraja Utara dikarakterisasi menggunakan 30 marka SSR dan dianalisis keragaman genetiknya menggunakan program NTSYS pc 2.1. Hasil penelitian menunjukkan bahwa duapuluh enam marka SSR yang dianalisis memiliki kisaran ukuran alel antara 106.75-311 bp, dengan jumlah alel rata-rata 3 dan tingkat polimorfisme sebesar 0,53. Koefisien kemiripan genetik 0,38 dan terbentuk 3 klaster. Pada klaster I dan klaster II didominasi oleh padi yang tidak memiliki rambut pada ujung gabahnya, dan pada klaster III didominasi oleh padi yang memiliki rambut pada ujung gabahnya. Selain itu, pada jarak genetik diatas 0,7 terdapat 105 peluang persilangan.Kata Kunci: keragaman genetik, marka SSR, padi lokal, tingkat polimorfisme, Toraja Utara

UJI AKTIVITAS ANTIJAMUR BEBERAPA SENYAWA MONOKARBONIL ANALOG CURCUMIN HASIL SINTESIS Rahmawati, Ismi; Purwaningsih, Desi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Antifungal Activity of Some Synthesized Mono-Carbonyl Analogue CompoundsÃ‚Â of CurcuminABSTRACTFungal resistance can pose a threat to future fungal infections, therefore studies to find other compounds that have antifungal activity need to be done. The aim of this study was to examine antifungal activity of synthesized curcumin analogue compounds i.e. 2,6-Bis-(2'-furilidin)-cyclohexanone (26FuH); 2,5-Bis-(2'-furilidine)-cyclopentanone (25FuP) and 1,5-Difuril-1,4-pentadien-3-on (15FuA). The curcumin analogue compound was successfully synthesized with Aldol condensation using KOH 7.5% as the catalyst. The compound was purified and characterized by melting point, thin layer chromatography, gas chromatography with mass spectrometry, FTIR spectrophotometry, spectrophotometry 1H-NMR. The results showed pure compounds and have a structure that corresponds to the target compounds. All compound were assayed as antifungal against Candida albicans, Pityrosporum ovale, Aspergillus niger, and Trichophyton mentagrophytes. The activity of each compound represented by inhibitory diameter was analyzed by one-way ANOVA followed by post hoc Tukey (p<0.05). All three compounds showed antifungal activity against Candida albicans, Pityrosporum ovale, and Aspergillus niger. The best antifungal activity was shown by 26FuH against Pityrosporum ovale.Keywords: antifungal activity, curcumin, monocarbonyl, Pityrosporum ovale, synthesisÃ‚Â ABSTRAKResistensi jamur dapat menjadi ancaman pada kasus infeksi jamur di masa mendatang, oleh sebab itu penelitian untuk menemukan senyawa lain yang memiliki aktivitas antijamur perlu dilakukan. Penelitian ini bertujuan untuk menguji aktivitas antijamur senyawa analog curcumin hasil sintesis yaitu senyawa 2,6-Bis-(2Ã¢â‚¬â„¢-furilidin)-sikloheksanon (26FuH); 2,5-Bis-(2Ã¢â‚¬â„¢-furilidin)-siklopentanon (25FuP) dan 1,5-Difuril-1,4-pentadien-3-on (15FuA). Senyawa analog curcumin sudah berhasil disintesis dengan metode kondensasi Aldol menggunakan katalis KOH 7,5%. Senyawa hasil sintesis dimurnikan dan dikarakterisasi dengan menggunakan pemeriksaan organoleptis, titik lebur, kromatografi lapis tipis, kromatografi gas dengan spektrometri massa, spektrofotometri FTIR, spektrofotometri 1H-NMR. Hasil menunjukkan senyawa murni dan struktur sesuai senyawa target. Hasil sintesis diuji aktivitas antijamur terhadap Candida albicans, Pityrosporum ovale, Aspergillus niger dan Trichophyton mentagrophytes. Hasil diameter daya hambat dianalisis dengan ANOVA satu arah dilanjutkan post hoc Tukey (p<0,05). Ketiga senyawa memiliki aktivitas antijamur terhadap jamur Candida albicans, Pityrosporum ovale, dan Aspergillus niger. Aktivitas antijamur terbaik adalah senyawa 26FuH terhadap jamur Pityrosporum ovale.Kata Kunci: aktivitas antijamur, curcumin, monokarbonil, Pityrosporum ovale, sintesis

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Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

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Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA