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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA" : 5 Documents clear
UJI KANDUNGAN BAKTERI Escherichia coli DALAM PRODUK OBAT TRADISIONAL YANG DIJUAL DI PASAR BERINGHARJO Ken Zaim Arifin; Nanik Sulistyani
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.883

Abstract

Indonesian traditional medicine has long been known and used by the community in maintaining health and treating illnesses. Identification of Escherichia coli bacteria was chosen because this bacterium is an indicator of sanitation and an unsanitary environment in the process of making traditional medicines. The purpose of this study was to determine the contamination of Escherichia coli bacteria in traditional medicines sold at the Beringharjo Traditional Market. This study was an experimental study. The sampling technique in this study was purposive sampling. culture technique on Echerichiae coli bacteria using TBX Agar Media and the Total Plate Number test using PCA. Bacterial analysis can be done by observing the culture media and test media on traditional medicine samples. The results of the ALT values were 70 ± 14,1 x 101  CFU/ml to 14,9 ± 1,2  x 105  CFU/ml and the Escherichia Coli Identification Test was negative or 0 colonies/g. the specified conditions refer to PerBPOM No. 32 of 2019. It can be concluded that in the ALT test of ten products, 80% of them have met the requirements and 20% of them do not meet the requirements. In the Escherichia Coli Identification Test, out of ten samples, all 100% of the samples met the requirements.
Uji Aktivitas Penghambatan Dipeptidyl peptidase-4 (DPP-4) Senyawa dari Lima Tanaman Indonesia secara In-silico Andri Prasetiyo; Shirly Kumala; Esti Mumpuni; Raymond R. Tjandrawinata; Lilik Sulastri
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.884

Abstract

ABSTRAKTeknik komputasi virtual screening dapat digunakan untuk memprediksi dan menjelaskan aktivitas senyawa apa yang berperan dalam penghambatan DPP-4. Lima tanaman Indonesia seperti Caesalpinia sappan, Mutingia calabura, Rheum palmatum, Ficus religiosa dan Tinospora crispa telah terbukti memiliki aktivitas penghambat dipeptidyl-peptidase-4 (DPP-4) secara in-vitro akan tetapi belum ada penjelasan senyawa apa yang berperan terhadap aktivitas tersebut. Penelitian ini bertujuan untuk memprediksi dan menjelaskan senyawa-senyawa dari lima tanaman yang memiliki aktivitas penghambatan DPP-4 secara In-silico. Metode docking menggunakan perangkat lunak Molegro Virtual Docker dengan 16 protokol kombinasi pencarian algortima dan fungsi nilai. Sebelum Docking dilakukan validasi metode dengan cara redocking native ligand protein penghambat DPP-4 dengan kode PDB 3G0B, kemudian dilanjutkan docking secara bersamaan 151 senyawa dari lima tanaman Indonesia dan 1 ligan standar alogliptin dengan reseptor dipeptidy lpeptidase-4 (kode PDB: 3G0B) dengan metode docking yang valid. Hasil validasi metode menunjukkan 16 protokol kombinasi memberikan nilai RMSD < 1 Å. Hasil docking berdasarkan rerank score paling rendah dan kemiripan interaksi residu asam amino dibandingkan ligan standar Alogliptin menunjukkan tiga senyawa 6'-O-Lactoyl Borapetoside B (rerank score -99.78 kcal/mol) dan Borapoteside A (rerank score -98.76 kcal/mol) dari tanaman Tinospora crispa dan Rhaponticin (rerank score -99.37) dari tanaman Rheum Palmatum  sedangkan ligan standar Alogliptin memiliki rerank score -93.14 kcal/mol dengan interaksi residu asam amino Glu206, Glu206, Tyr547, Tyr632. Metode docking dengan mvd terbukti valid dan Physcion 8-gentiobioside, Luteolin 4'-metil eter 7-glukosida, 6'-O-Lactoyl borapetoside B, Rhaponticin dan Tinocrispol A diprediksi memiliki aktivitas penghambatan DPP-4.Kata Kunci: docking, penghambat DPP-4, Tinospora crispa, Rheum palmatum
FORMULASI SEDIAAN EMULGEL EKSTRAK DAUN UNGU DENGAN PENAMBAHAN BIOENHANCER EKSTRAK LIDAH BUAYA Asri Wulandari; Erni Rustiani; Septia Andini; Daniel Sinaga
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.963

Abstract

Purple leaves contain flavonoids as anti-inflammatory. Aloe vera contains lignin compounds as bioenchancers. Utilization of these two plants in the form of topical emulgel preparations with the hope of being able to reach the systemic circulation. This study aims to formulate purple leaf extract and aloe vera extract in the form of an emulgel. The formula was made in 4 variations with concentrations of aloe vera extract F0 (0%), F1 (2.5%), F2 (3%), F3 (3.5%). Quality parameters include organoleptic, pH, spreadability, viscosity, cycling test, and penetration test using cell diffusion method franz. The results showed that the aloe vera extract emulgel formulation had good physical quality, namely organoleptic viscous green color, characteristic aromatic odor, pH 4.66-5.01, spreadability 5.63-6.03 cm2, viscosity 8100-9100 cPs. The results of the stability cycling test did not show changes in organoleptic and pH of the preparation, while the viscosity of the preparation decreased. Penetration test results based on statistical analysis of purple leaf extract emulgel obtained p> 0.05, which means that the addition of aloe vera extract bioenhancer did not have a significant effect on the value of the cumulative amount and flux.Keywords: emulgel, bioenchancer, penetration, franz diffusion cell
Senyawa Antiinflamasi dari Fraksi Etil Asetat Akar Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Udema Kaki Mencit Terinduksi Karagenan Diva Feraldy; Endah Sayekti; Ari Widiyantoro
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.885

Abstract

Inflammation can occur due to insect bites, toxins, burns and blows. Inflammation can be cured using Non-Steroid Anti-Inflammatory Drugs (OIANS). Fragrant pandan root is thought to have anti-inflammatory activity because it contains alkaloids and flavonoid compounds. This study aims to determine the activity and characteristics of anti-inflammatory compounds from extracts, fractions and isolates of ethyl acetate root of fragrant pandan (Pandanus amaryllifolius Roxb.) against carrageenan-induced foot edema of mice. The process of isolation of fragrant pandan roots includes stages such as maceration, partitioning and chromatography. The results of the study The methanol extract had good activity at a dose of 200 mg/kg BB for a period of time (t3) 51.7%; the methanol fraction had good activity at a dose of 200 mg/kg BB in the time span (t3) 38.2%; the ethyl acetate fraction had good activity at a dose of 200 mg/kg BB over a period of time (t3) 56.9%; the dichloromethane fraction had good activity at a dose of 200 mg/kg BB in the time range (t3) 59.2%; the n-Hexane fraction had good activity at a dose of 200 mg/kg BB for a period of time (t3) 37.1%; and isolates had good activity at a dose of 50 mg/kg BB over a period of time (t3) 35.6%. K2 isolate from the ethyl acetate fraction was characterized using 1H-NMR with DMSO solvent at a frequency of 500 MHz and 13C-NMR with DMSO solvent at a frequency of 125 MHz. K2 isolate from the ethyl acetate fraction had similarities to Pandalisines A.
Pengaruh Metode Ekstraksi Terhadap Senyawa Flavonoid Total Ekstrak Etanol Daun Patikan Kebo (Ephorbia hirta) Fahzlurahman Paokuma; Rezki Amriati Syarif; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.964

Abstract

Euphorbia (Euphorbia hirta) merupakan tanaman yang banyak digunakan dalam pengobatan tradisional. Salah satu senyawa aktif yang terdapat pada ekstrak etanol daun Euphorbia adalah flavonoid. Penelitian ini bertujuan untuk mengetahui pengaruh variasi metode ekstraksi terhadap kandungan flavonoid total pada ekstrak daun Euphorbia. Ekstraksi sampel menggunakan metode perkolasi dan refluks dengan nilai rendemen untuk metode perkolasi sebesar 4,3% dan metode refluks sebesar 5,3%. Analisis kualitatif sampel menggunakan Kromatografi Lapis Tipis (KLT). Penentuan kadar flavonoid total ekstrak etanol daun Euphorbia diperolehdari data spektrofotometer UV-Vis. Panjang gelombang maksimum yang digunakan adalah 429 nm. Hasil penelitian menunjukkan bahwa kandungan total flavonoid ekstrak etanol daun Euphorbia untuk metode perkolasi adalah 2,32% dan untuk metode refluks adalah 3,21%.

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