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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA" : 5 Documents clear
Daun Cempaka Kuning (Michelia champaca Linn) sebagai Kandidat Penghambat Enzim α-glukosidase secara In Silico Amalia, Riyanti; Meiliana, Made Laksmi; Hamidu, La
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1183

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs worldwide and continues to increase rapidly. The purpose of this study was to determine the activity and mechanism of action of the antioxidant compounds in cempaka kuning leaves as an antidiabetic using the in silico method. This study used 8 antioxidant compounds from cempaka kuning leaves, namely octadecadienoic acid, butanoic acid, oleic acid, camphorsulfonic acid, pimaric acid, phenol, andrographolide, and benzoic acid. The α-glucosidase enzymes used in this study were obtained from the Protein Data Bank website with the PDB ID codes 3A4A and 2QMJ. Ligand-macromolecule docking using AutoDockTools (ADT) and AutoDock Vina programs. The results showed that the antioxidant compounds in cempaka kuning leaves that had the lowest ΔGbind values were pimaric acid (-8.9 kcal/mol) and andrographolide (-8.6 kcal/mol) in PDB ID 3A4A. The docking results used PDB ID 2QMJ, the compound with the smallest ΔGbind was andrographolide (-7.4 kcal/mol). The results of visualization of the interaction of the ligand with the macromolecular amino acid residue PDB ID 3A4A showed that the residues Arg315, Arg442, and Tyr158 were found in the compound with the smallest ΔGbind. In the PDB ID 2QMJ macromolecule, Asp542 residue was found in all compounds with the smallest ΔGbind. Based on these results, the compounds pimaric acid and andrographolide have potential as antidiabetic drugs compared to other compounds with a mechanism of action of inhibiting the α-glucosidase enzyme.
Pengaruh Variasi Metode Ekstraksi Jahe dan Serai terhadap Aktivitas Antiinflamasi pada Penghambatan Denaturasi Protein Faradiba, Faradiba; Syarif, Rezki Amriati Amriati; Khaira, A Tenri Mifta; Alyanti, Tifani Kursya
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1184

Abstract

The content of secondary metabolites or chemical content in medicinal plants affects pharmacological activity. The level of chemical content is affected by the extraction method. Previous research has been conducted on the extraction of ginger and lemongrass using two methods, which include maceration and ultrasonic. The results obtained are differences in chemical content that have the potential to have anti-inflammatory activity. Ginger (Zingiber officinale) contains chemical compounds, including gingerol, shogaol, and zingeron. linalool, alpha-pinene, and sineol. Lemongrass (Cymbopogon citratus) contains citronellal, citronellol, geraniol, flavonoids, and tannins. The aim of this study was to compare the invitro anti-inflammatory activity of ginger and lemongrass extracts using two extraction methods: maceration and ultrasonic. The research method consists of two stages, i.e. extraction of samples using maceration and  ultrasonic methods. The second stage is testing the anti-inflammatory activity against BSA (Bovine Serum Albumin) denaturation of extracts from maceration and ultrasonic methods with the parameter of percentage value to be more than 20%. The results obtained from ginger and lemongrass extracts showed the percentage value of inhibition at concentrations of 10 µg/mL, 12.5 µg/mL, 17.5 µg/mL, and 20 µg/mL are all more than 20%. The ultrasonic extraction of ginger showed a more linear inhibition percentage than the results of maceration. Macerated lemongrass extract showed a more linear percentage inhibition than ultrasonic results.
Aktivitas Penghambatan Enzim α-Glukosidase Senyawa β-Sitosterol dari Fraksi Etil Asetat Daun Salam [Syzygium polyanthum (Wight.) Walp Sulastri, Lilik; Zulfadhli, Muhammad; Alwie, Rakhmat Ramdhani; Ramani, Sofyan; Prasetiyo, Andri; Simanjuntak, Vino Soaduon
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.981

Abstract

Diabetes mellitus, also known as diabetes, is an endocrine disease characterized by sustained high blood sugar levels. Diabetes is caused by the pancreas not producing enough insulin, or the body's cells becoming unresponsive to the effects of the hormone. Common symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, such as disorders of the cardiovascular system, eyes, kidneys, and nerves. In general, the treatment of diabetes mellitus is done with insulin therapy and various synthetic drugs, but these treatments have side effects. Another alternative is treatment using herbs, including salam leaves (Syzygium polyanthum (Wight.) Walp) which can be used as an inhibitor for the α-glucosidase enzyme. This study aims to isolate and determine the levels of β-sitosterol from the ethyl acetate fraction of salam leaves which have α-glucosidase enzyme inhibitory activity. Extraction was carried out by maceration using 96% ethanol, then partitioned with ethyl acetate and water (1:1). The ethyl acetate fraction was tested for the inhibitory activity of the α-glucosidase enzyme, then isolated by column chromatography method (SiO2; i.n-hexane-ethylacetate = 10 : 1 ~ 1 : 1, ethylacetate; ii.n-hexane-ethylacetate = 5 : 1 guided by testing enzyme inhibitory activity until pure isolates were obtained. The isolates were identified by spectrophotometry (IR) compared with the standard β-sitosterol compound. The results showed that isolates F.4-5 was a β-sitosterol compound with a concentration of 177.13 mg/g extract and had α-glukosidase enzyme inhibitory activity with an IC50 of 93.7 μg/mL.
Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung Widyastuti, Lita; Herowati, Rina; Ariawan, M Wahyu; Purwidyaningrum, Ika
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1064

Abstract

Gastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO.
Pengaruh Ekstrak Pogostemon cablin Benth terhadap Interleukin-6, Glukosa Darah, Hemoglobin dan Hematokrit pada Tikus Wistar yang Diinduksi Dietilnitrosamin Atmaja, Ratih Feraritra Danu; Yuniarty, Tuty; Misbah, Sitti Rachmi; Malik, Handayani
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1092

Abstract

Mortality and morbidity rates of hepatocellular carcinoma continue to rise worldwide. The role of inflammation, regulation of glucose metabolism, and anemia is widely studied concerning the development and life expectancy of patients with hepatocellular carcinoma. In several cancers, efforts to develop Pogostemon cablin benth plant potential drug candidates for hepatocellular carcinoma have been carried out at metabolomic, proteomic, and molecular levels. However, no studies have been found regarding the study of anti-inflammatory effects, metabolism, and anemic conditions of Pogostemon cablin benth intervention in hepatocellular carcinoma. This study is a pre-post experimental in-vivo study aimed at looking at the ability of Pogostemon cablin benth extract against interleukin-6 (IL-6) as an inflammatory marker, blood glucose levels as a marker of metabolic regulation and hemoglobin and hematocrit levels at as markers of anemia in hepatocellular carcinoma. A model of hepatocellular carcinoma was performed in 25 peritoneal-induced diethylnitrosamine-induced Wistar rats. The mice were divided into five groups, namely group 1 (K1), group 2 (K2), group 3 (K3), positive control (KP), and negative control (KN). Pogostemon cablin benth ethanol extract was administered orally to mice K1 40mg/kg body weight; K2:80mg/kg rat body weight; K3:120mg/kg body weight, while the positive control group was given Sorafenib. Interleukin-6 levels were measured using the enzyme-linked immunoassay principle, while glucose, hemoglobin, and hematocrit levels were measured using the enzymatic principle of glucose dehydrogenase-flavin adenine dinucleotide (GDH-FAD). The study showed no difference in blood glucose levels of mice between pre- and post-induction diethylnitrosamine. Induction of diethylnitrosamine obtained significantly led to a significant decrease in hemoglobin levels (15.54 g/dl ±1.28 vs. 14.31 g/dl ±1.11) and hematocrit (45.83% ±3.77 vs 42.20% ±3.25) levels between pre and post-induction. Mice in group 1 (K1) showed a significant increase in blood glucose levels between pre and post-oral Pogostemon cablin benth extract (p<0.05). There was no significant difference in hemoglobin and hematocrit levels in the treatment group between pre-intervention Pogostemon cablin benth extract. However, KN that did not receive Pogostemon cablin benth extract intervention significantly decreased hemoglobin and hematocrit levels (p<0.01). Decreased levels of the pro-inflammatory cytokine IL-6 occurred in K2 (p<0.05) after receiving oral Pogostemon cablin benth extract intervention. Based on this study, Pogostemon cablin benth extract may decrease IL-6 levels and is thought to influence hemoglobin and hematocrit levels in diethylnitrosamine-induced Wistar rats.

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