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BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan)
Published by Universitas Medan Area
ISSN : 25975269     EISSN : 2356458X     DOI : 10.31289
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology
Biolink focuses on the publication of the results of scientific research related to fields. This article is published in the internal and external academic community of the University of Medan Area (UMA) especially in the field of Biology. Biolink publishes scientific articles in the scope of biology that includes environmental biology, industrial biology and health biology. Published articles are the results of research articles, studies or critical and comprehensive scientific studies on important issues related to the field of biology.
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Articles 15 Documents
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Search results for , issue "Vol. 12 No. 2 (2026): Biolink February" : 15 Documents clear
MICROALGAE METALLOTHIONEIN OPTIMIZATION THROUGH GENETIC ENGINEERING FOR BIOREMEDIATION AND BIOLOGY EDUCATION Magfirah, Nurul; Hartati, Hartati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.16729

Abstract

Heavy metal pollution (e.g., Cd, Pb, Hg) threatens aquatic ecosystems due to its persistence, toxicity, and bioaccumulation. Microalgae are promising agents for bioremediation via bioadsorption and intracellular bioaccumulation, but their intrinsic metal uptake is often inadequate under high contamination. This review aimed to synthesize current evidence on metallothionein (MT)-based enhancement of microalgae bioremediation and to map its relevance for project-based and STEM-oriented biology learning. A narrative (descriptive–analytical) literature review was conducted using recent publications (primarily within the last 10 years) on MT/PC mechanisms, microalgae genetic engineering and synthetic biology, genome editing, and biosafety. Content analysis was used to extract and integrate findings. The review indicates that MT functions as a metal buffer, detoxifier, and antioxidant, and that MT performance can be improved through (i) target-gene selection informed by omics and motif/phylogenetic analyses, (ii) construct design with strong/metal-inducible promoters and subcellular targeting, (iii) pathway-level co-engineering (transporters, glutathione/antioxidant systems), and (iv) genome editing (e.g., CRISPR-based knockout of inhibitory regulators). Biosafety-by-design strategies (biocontainment, auxotrophy, closed photobioreactor deployment) are critical for real-world use. Overall, MT-centered engineering offers a feasible route to strengthen microalgae bioremediation and provides an authentic context for integrating biotechnology with socio-scientific issues in biology education.
MOLECULAR PHYLOGENY OF RODENTIA DERIVED FROM NRAS GENE SEQUENCES Foenna, Yudi Gebri; Hartono, Hartono; Maelani, Imelda
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.16827

Abstract

Rodentia is the most diverse mammalian order, yet phylogenetic relationships among several rodent lineages remain incompletely resolved, particularly when inferred predominantly from mitochondrial markers. This study aims to assess the potential of the nuclear NRAS (Neuroblastoma RAS viral oncogene homolog) gene for reconstructing rodent phylogeny. A total of 18 NRAS nucleotide sequences representing major rodent families were retrieved from the NCBI GenBank database, with Equus caballus and Oryctolagus cuniculus used as outgroups. Sequence alignment and model selection were performed using MEGA 12 under Maximum Likelihood criteria. Phylogenetic reconstruction was conducted using the Maximum Likelihood method with the T92+G+I substitution model and 1,000 bootstrap replicates. Pairwise genetic distances were estimated using the p-distance method and visualized through a heatmap to examine divergence patterns. The results indicated that NRAS evolution is best explained by models incorporating invariant sites and rate heterogeneity, reflecting strong functional constraints combined with lineage-specific variation. The inferred phylogeny is largely congruent with established rodent systematics, and genetic distance patterns independently support the recovered topology. These findings suggest that NRAS represents a reliable nuclear marker that offers complementary phylogenetic information alongside mitochondrial data in Rodentia phylogenetic studies.
ANTIFUNGAL EFFECTIVENESS OF BAJAKAH ROOT EXTRACT (Uncaria acida) AGAINST THE ACTIVITY OF Malassezia furfur, THE CAUSATIVE AGENT OF SEBORRHEIC DERMATITIS IN MICE Ningsih, Ira Wahyu; Rohmadi, Mukhlis; Indahsari, Lilin Ika Nur
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.16935

Abstract

Seborrheic dermatitis is a chronic skin disorder associated with colonization by Malassezia furfur and is commonly treated with topical antifungal agents and corticosteroids, which may cause adverse effects when used long term. Therefore, safer and more sustainable alternative therapies derived from natural products are needed. One such candidate is bajakah root (Uncaria acida), which is known to contain flavonoids, alkaloids, tannins, terpenoids, and saponins with potential antifungal activity. This study employed a true experimental posttest-only design involving 24 male BALB/c mice induced with Malassezia furfur and divided into a negative control group (distilled water), a positive control group (ketoconazole), and treatment groups receiving Uncaria acida extract at concentrations of 25%, 50%, 75%, and 100%. The research stages included extr act preparation using ethanol maceration, ointment formulation, fungal infection induction, and clinical evaluation. Phytochemical analysis confirmed a total flavonoid content of 28.5 mg QE/g. The results demonstrated significant differences across all clinical parameters (p < 0.05), with the 75% extract concentration providing the most optimal clinical improvement. These findings indicate that Uncaria acida extract has strong potential for development as a topical herbal therapeutic candidate and provides a foundation for further studies focusing on formulation optimization and clinical trials.
PRELIMINARY ASSESSMENT OF PLANT DIVERSITY IN FOUR HABITAT TYPES IN REBONJARO SURVEY AREA, SOUTH SUMATRA Pragustiandi, Guntur; Aprillia, Ina; Sevli, Melto
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.17083

Abstract

Land-use change in tropical landscapes poses increasing threats to plant diversity, yet baseline floristic data from transitional forest–agroecosystem areas in South Sumatra remain limited. This study aimed to document plant species diversity, floristic composition, and conservation status across four habitat types in the Rebonjaro forest landscape: secondary forest, shrubland, mixed rubber plantation, and oil palm plantation. Vegetation surveys were conducted in 2024 using purposive belt line transects adapted from rapid vegetation assessment methods. Species were recorded through direct field observation within ±10 m of transect lines, with transect lengths ranging from 100–300 m. Conservation status was assessed using the IUCN Red List (version 2024-2) and Indonesia’s Ministry of Environment and Forestry Regulation No. 106/2018. A total of 175 plant species representing 61 families were recorded, with Euphorbiaceae, Fabaceae, and Moraceae being the most species-rich families. Most species were categorized as Least Concern, while Aquilaria malaccensis was identified as Critically Endangered and Gluta renghas and Syzygium laxiflorum as Near Threatened. The results indicate that modified landscapes, particularly mixed rubber plantations, retain considerable plant diversity. This checklist provides essential baseline data to support long-term biodiversity monitoring and conservation planning in landscapes undergoing rapid land-use change.
ANTIOXIDANT ACTIVITY AND CURCUMIN LEVELS OF TEMULAWAK (Curcuma xanthorrhiza ROXB.) EXTRACT AND ITS EFFECTS ON BLOOD CELLS IN ALCOHOL-INDUCED WHITE RATS (Rattus norvegicus L.) Al – Husnaini, Nabila; Syukriah , Syukriah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.17278

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) is a traditional Indonesian medicinal plant rich in Curcumin and active compounds such as triterpenoids, alkaloids, saponins, and flavonoids, which exhibit antioxidant and anti-inflammatory properties. Curcumin content was quantified at 109.58 mg/g using the UV-Vis spectrophotometry method, and its antioxidant activity was confirmed through increasing DPPH inhibition percentages with increasing extract concentrations, with the IC₅₀indicating significant radical scavenging potential. Excessive 45% ethanol intake can induce oxidative stress and alter white blood cell counts. This study used 20 male white rats (Rattus norvegicus L.) weighing 180–200 g, divided into normal control, alcohol control, and ginger extract treatment groups at doses of 100, 200, and 300 mg/kg body weight. Hematological parameters observed included erythrocytes, hemoglobin, hematocrit, MCV, MCH, MCHC, platelets, and total and differential leukocyte counts. Results showed that ginger extract, particularly at 200 mg/kg, stabilized blood profiles after alcohol consumption, with hematological values approaching normal levels. Differences between groups were not statistically significant, indicating the safety and antioxidant potential of ginger extract.

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