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International Journal of Cardiovascular Practice

ijcp
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Published by Shahid Beheshti University of Medical Sciences

ISSN : 24767174 EISSN : 2476468X DOI : -

Core Subject : Health,

Medicine & Pharmacology

International Journal of Cardiovascular Practice(IJCP) is an international quarterly journal dedicated to a broad spectrum of topics in cardiology. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.

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Articles 29 Documents

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Search results for , issue " In Press" : 29 Documents clear

Left Ventricular Torsion Deformation in Atrial Septal Defect Patients Undergoing Transcatheter Device Closure Razak, Abdul; Mohd. Al Hajri, Maryam Said; Shetty, K Ranjan; Nayak, Krishnananda
International Journal of Cardiovascular Practice In Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Atrial septal defects (ASD) considered being one of the known congenital heart diseases. ASD causes increased volume overload of the right heart. The purpose of this study was to evaluate left ventricular (LV) torsion deformation in ASD patients undergoing transcatheter device closure.Methods: All adult patients who underwent transcatheter device closure with ostium secundum ASD were included in the study. We assessed LV torsion in ostium secundum ASD patientâs pre and post device closure by using speckle tracking echocardiography.Results: A total of 37 patients (22 females and 15 males) were included in this study. The average age was 28 Â± 19 years. LV peak basal rotation improved significantly (P = 0.028) in post transcatheter closure. LV torsion (2.88 Â± 0.99Ë/cm before vs. 3.40 Â± 1.41Ë/cm after closure, P = 0.009) and twisting (15.12 Â± 4.69Ë before vs. 17.95 Â± 6.21Ë after closure, P = 0.005) were statistically significant in post transcatheter closure. Volumetric assessment of LV including end-diastolic volume and systolic volume showed significant improvement (P = 0.02, P < 0.01) post device closure.Conclusions: The increased peak LV twisting and torsion was mainly attributed to the improved peak systolic clockwise rotation after ASD device closure. The LV twisting at a younger age was improved after the closure of ASD.

9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology Omidi, Soodeh; Ebrahimzadeh, Fatemeh; Kalayinia, Samira
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

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Coronary artery disease (CAD) is a disease of major concern worldwide. It is the main cause of mortality in many societies and improving the understanding about the CAD mechanism, progression and treatment, is necessary. Recent discovery of genetic factors underlying CAD has improved our knowledge of the disease in support of well-known traditional risk factors. Genotype-environment interaction is known as the main risk factor. Loci on many different chromosomes have been identified as a risk factors that increase CAD susceptibility. Here we performed a comprehensive literature review pinpointing hotspot loci involved in CAD pathogenicity. The 9p21.3 locus is the most common region associated with CAD and its specific structure and function have been remarkable in many studies. Moreover, the variations in the 9p21.3 locus have been implicated in CAD patients in different populations around the world. According to conclusions from this the 9p21.3 locus can be the first point of focus in etiology investigations of CAD patients.

Assessment of Strain and Strain Rate in Patients with Coronary Artery Disease Before and After Percutaneous Intervention on Left Anterior Descending Coronary Artery Heidari Sarvestani, Ali; Separham, Ahmad; Khezerloo, Naser
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Strain (S) and Strain Rate (SR) as echocardiography parameters are important in assessing changes in myocardial tissue and global and regional evaluation of systolic and diastolic functions and in detection of myocardial disorders as they change in early stages of myocardial ischemia. Therefore, the aim of this study was to compare changes of S and SR indices in systolic phase in patients with a significant stenosis of left anterior descending (LAD) before and after percutaneous coronary intervention (PCI).Methods: 48 patients candidate for PCI with significant lesion in LAD were enrolled in this study. Echocardiographic images taken one day before and a week after PCI. Echocardiographic scope of the LAD was defined as mid, basal, anteroseptal and mid-septal and apical segments then, S and SR parameters in all segments measured separately during systolic phase before and after PCI and compared together.Results: there was a significant increase after PCI only in two segments and SR values showed significant increase after PCI in four segments. In the analysis of sum of mean parameters, a significant increase was observed in SR values (10.12 to 11.30; P = 0.001), but not in S values (149.54 to 143.36; P = 0.1)Conclusions: The remedial effect of PCI on deformation values was observed in the first week. In early reperfusion period, S/SR indices have potential to be used as determinants of favorable response to revascularization therapy.

Serum Cortisol Level as a Predictor of In-Hospital Mortality in Patients Undergoing Primary Percutaneous Intervention for ST Segment Elevation Myocardial Infarction RAO, M SUDHAKAR; Devasia, Tom; Kareem, Hashir; R, Padmakumar; AJ, Ashwal
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Various laboratory markers have been proposed to assess prognosis in myocardial infarction. Serum cortisol is one such laboratory marker. There are only few studies done in the recent past which prove that cortisol is a prognostic marker in STEMI.Methods: We studied a total of 168 patients who presented with STEMI and underwent primary percutaneous intervention (PPCI) within 12 hours of symptom onset between April 2016 and November 2016.Results: The average age of study population was 61 ± 0.12 years. Males were predominant (n = 132, 78.57%). 155 patients survived, whereas 13 patients died in the hospital. Mean syntax score was 16.65 ±5. 33 among patients who died, whereas it was 13.11 ± 5.62 among survivors (P = 0.03). Mean cortisol was significantly higher among the patients who died (46.13 ± 14.61 mcg/dl) than the survivors (31.16 ± 13.16 mcg/dl) (P = 0.003). The ROC AUC for in-hospital mortality was 0.77 (95% confidence interval [CI], 0.645–0.897). An optimal cut-point identified from the ROC curve was a random serum cortisol concentration of 33.66 mcg/dl, with corresponding sensitivity and specificity of 69.2 % and 64 %, respectively. At a cut-point of 29.55 mcg/dl, sensitivity and specificity were 84.6 and 50 %, respectively.Conclusion: This study showed that serum cortisol level is a strong predictor of mortality in patients undergoing PPCI for STEMI. Levels more than 33.66 mcg/dl can predict mortality with a sensitivity of almost 70 percent and specificity of 64 percent.

A Prospective Study of Prevalence of Carotid Artery Disease in Patients with Coronary Artery Disease and its Correlation with Traditional Atherosclerotic Risk Factors in Central India Chandra, Umesh Kumar; Panwar, Yashwant; Bharani, Anil
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Early atherosclerosis mainly involves carotid artery, which leads to increased carotid artery intima media thickness (CIMT).The potential value of CIMT improving the predictive capacity of traditional risk factors of CAD is an understudied and underutilized issue. Because of increasing availability of highly sensitive ultrasonography probes and for a noninvasive procedures, we can predict coronary artery disease (CAD) more precisely in patients having multiple traditional risk factors so it may reduce morbidity and mortality due to CAD and elevated CIMT can be used as surrogate marker of underlying CAD.Methods: This study enrolled 250 admitted patients as a case of CAD. The patients were assessed by detailed history taking, thorough clinical examination, measurement of CIMT, blood sugar and lipid level.Results: Carotid artery disease was present in 88 (35%) of 250 CAD patients. All modifiable cardiovascular risk factors were statistically significantly high in patients of CAD with carotid artery disease. In obese, diabetic, hypertensive, dyslipidemia and smoker patients, carotid artery disease was present in 55% (P = 0.00), 41% (P = 0.00), 43% (P = 0.007), 47% (P = 0.002) and 43% (P = 0.003) respectively. CAD patients who had 1 risk factor, 29% were associated with carotid artery disease. Comparison of single risk factor with patients who had no risk factor, there was non-significant correlation for carotid artery disease. CAD patients who had 2, 3, 4 and 5 risk factors, carotid artery disease was present 24 (32%) (p = 0.02), 15 (55%) (P = 0.0003), 17 (61%) (P = 0.00006) and 6 (67%) (P = 0.0008).Conclusion: elevated CIMT can be used as one of the important risk factor for early diagnosis of CAD and to reduce morbidity and mortality due to CAD.

endovascular repair of an isolated iliac artery aneurysm in a patient with liver cirrhosis Tahooni, Azadeh; Vahedinezhad, Milad
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Endovascular repair is increasingly becoming the main strategy for management of aortic and peripheral aneurysms. Several methods have been chosen to treat aneurysms based on the anatomy, coexisting nearby aneurysms and available tools. We present a 60 years old man with an isolated large iliac artery aneurysm which discovered incidentally and was treated using an endovascular approach and obliterating internal iliac artery without early and late complications at 3 years long follow up.

DIFFERENT POLYMORPHISMS OF PLACENTAL GROWTH FACTOR (PLGF) GENE IN IRANIAN WOMEN'S POPULATION WITH PRE-ECLAMPSIA Pourroostaei Ardakani, Parisa; Ramezani, Arezoo; Piravar, Zeinab; Asgharimoghadam, Nastaran; Behzadi, Roudabeh; Jafari Fesharaki, Mehrdad
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. Due to the importance of mutations in the PLGF (Placental Growth Factor) gene and the association with the incidence of preeclampsia, this study aimed to evaluate the association of polymorphisms of the PLGF gene with the prevalence of preeclampsia in Iranian women.Methods: Fifty pregnant women with pre-eclampsia diagnosis and 50 healthy pregnant women for determination of genotypes rs1464547123, rs12411, rs1399853427, and rs1312670436 were evaluated using the Sanger sequencing method.Results: There was no significant difference in the frequency of alleles ofrs1464547123, rs1399853427 and rs1312670436 polymorphisms between case and control groups (P > 0.05), but the rate of recessive allele A in rs12411 polymorphism was significantly higher in the case group than in the control group (case = 24%, control = 8%, P-Value = 0.04), while the frequency of the allele T in the control group was higher than that of the patient group (case = 76%, control = 92%, P-Value = 0.04) The frequency of AT genotype in the patient group was a none significantly higher than the control group (case = 8%, control = 4%, P-Value = 0.1) and the frequency of AA genotypes in the case group was none significantly higher than that of the control group (case = 16%, control = 4%, P-Value = 0.1).Conclusions: The results revealed that polymorphism rs12411 of the gene encoding PLGF has a significant difference among individuals with and without pre-eclampsia and can affect the incidence of pre-eclampsia among Iranian women.

PULMONARY CAPILLARY HEMANGIOMATOSIS: A RARE CAUSE OF PULMONARY ARTERIAL HYPERTENSION, PRESENTING AS SUPRAVENTRICULAR TACHYCARDIA Dattaprasad, Ganganpalli; Chandra, Umesh Kumar; Vishwakarma, Sumit Kumar; Pandey, V.P.; Dubey, Sanjay
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

With a prevalence of less than 1/million, Pulmonary Capillary Hemangiomatosis is a rare disorder of capillary proliferation in the alveolar septae leading to pulmonary arterial hypertension and mimics pulmonary veno-occlusive disease.

PREVALENCE OF NON-THROMBOEMBOLIC INCIDENTAL FINDINGS ON COMPUTED TOMOGRAPHY-PULMONARY ANGIOGRAPHY FOR PULMONARY Bozorgmehr, Rama; Pishgahi, Mehdi; Mohaghegh, Pegah; Bayat, Marziye; Khodadadi, Parastou; Ghafori, Ahmadreza
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Computed Tomography-Pulmonary Angiography (CTPA) is a noninvasive imaging modality for direct diagnosis of pulmonary thromboembolism. The potential advantage of CTPA is possible alternative and incidental findings in cases that PTE is ruled out. This study was performed to determine the prevalence of incidental findings in CTPA in patients suspected to have PTE.Methods: This cross-sectional retrospective study was performed in patients with suspected PTE admitted to Shohada-e-Tajrish Hospital in 2014 and 2015 and underwent CTPA for final diagnosis. Incidental findings in CTPA and associated clinical symptoms were assessed.Results: According to CTPA performed in 188 patients, PTE was diagnosed in 61 cases (32.4%). Prevalence of incidental abnormal findings in the two groups with and without PTE were 93.7% and 90.9%, respectively. The most common incidental finding was pleural effusion (42%). There was no significant association between clinical symptoms and incidental findings in CTPA in patients with suspected pulmonary embolism (P > 0.05). The only significant finding was association between lung mass and tachypnea (P=0.007).Conclusion: In patients with primary clinical symptoms of suspected pulmonary embolism, in most cases there was a wide range of incidental findings and simultaneous pathologies in CTPA mimicking the primary symptoms of pulmonary embolism. However, in this study there was no significant association between clinical symptoms and incidental findings. Determination of definite indications of CTPA in patients with suspected pulmonary embolism is necessary.

EFFECT OF RETROGRADE AUTOLOGOUS PRIMING ON CLINICAL OUTCOME OF CARDIOPULMONARY BYPASSING ON PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING Rafiee, Musa; Zia Toutounchi, Mohammad; Yazdani, Rezvan; Mohammadi, Nooredin
International Journal of Cardiovascular Practice Article in Press
Publisher : International Journal of Cardiovascular Practice

Introduction: Cardiopulmonary bypass is a standard and low mortality-associated method used across the world. This method allows cardiac surgery to be performed in a bloodless environment. The study aimed to compare Conventional priming and Retrograde autologous prime (RAP) on patients undergoing coronary artery bypass grafting (CABG).Methods: The study population was patients undergoing CABG using cardiopulmonary bypass in Rajaei Hospital, of whom 80 patients were selected by simple random sampling convenience sampling and then were randomly assigned to two groups: Conventional priming and RAP. Demographic information, blood components transfused in the operating room and the intensive care unit, ejection fraction (EF) of left ventricle and changes in blood gases were collect.Results: The mean requirement for red blood cell transfusion bags to the patient during surgery was lower in the RAP group than the conventional priming group (P = 0.002). But the difference after surgery in both groups was not significant statistically (P = 0.2). The difference amount of platelet transfusion during operation the difference was not statistically significant (P = 0.4). The difference postoperative platelet transfusion was not statistically significant (P = 0.7). The fresh frozen plasma transfusion during surgery in the RAP group lower than the usual prime group, but the difference was not statistically significant (P = 0.406). The Fresh frozen plasma (FFP) transfusion after surgery in the two groups was not statistically significant (P = 0.217).Conclusion: RAP is compared with conventional priming a safe and low-cost technique in reducing the priming volume of the CPB system, causes less hemodilution, and reduces the need for intra- and postoperative blood transfusion. Therefore, it is recommended to consider RAP as an effective and low-cost technique of priming Cardiopulmonary bypass circuits.

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