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Sumatera utara
INDONESIA
Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 12, No 1 (2027)" : 7 Documents clear
Comparative In Vitro Analysis of Propolis and 3% Hydrogen Peroxide as Cerumenolytic Agents in Children Ritonga, Doli Naufal; Nasution, Muhammad Edy Syahputra
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract: Cerumen impaction is a common otologic problem that can impair hearing and predispose individuals to external ear infections. This in vitro study aimed to compare the cerumenolytic effects of propolis and 3% hydrogen peroxide using spectrophotometric absorbance measurements at 5, 10, 15, and 30 minutes. A total of 48 cerumen samples were collected from children at Panti Asuhan Putri Aisyiyah Medan and divided equally into two treatment groups. Absorbance values were analyzed using non-parametric statistical tests due to non-normal data distribution. Propolis demonstrated a progressive increase in absorbance over time, reaching its highest effect at 30 minutes, whereas hydrogen peroxide showed minimal changes with no significant time-dependent pattern. Comparative analysis revealed that propolis produced significantly higher absorbance values than hydrogen peroxide at all time points (p 0.001), indicating superior cerumen dissolution. These findings suggest that propolis may serve as a more effective and potentially safer alternative to hydrogen peroxide for cerumen management. Further in vivo and clinical studies are recommended to validate its therapeutic applicability and long-term safety.
Effect of Vitamin E Use on Hot Flash Reduction in Menopausal Women Sibagariang, Fadlullah Asykari; Sinaga, Rahmanita
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract : Hot flash is a sudden hot sensation that usually appears in the chest, neck, and face, accompanied by sweating, heart palpitations, and can be triggered by a warm environment, hot drinks, or emotional stress. These symptoms are often the main reason women seek medical care during perimenopause because it can interfere with quality of life. Vitamin E, with its antioxidant properties, has been shown to be able to reduce the intensity and frequency of hot flashes through improved adrenal function. This study aims to assess the effect of Vitamin E administration on the reduction of hot flashes in menopausal women. The method used was an experiment with administering Vitamin E daily for four weeks to the study subjects. Data was obtained from a questionnaire of hot flash patients in 2022 at Bhayangkara Hospital Medan based on a doctor's examination and the HFRS scale. The results of the statistical test showed a P-Value of 0.000, lower than alpha 0.05, so the null hypothesis was rejected. In conclusion, Vitamin E is significantly effective in reducing hot flashes in menopausal women.
The Effect Of Smart Phone Use Intensity On Academic Procrastination And Learning Motivation Of Students At Muhammadiyah University Of North Sumatera Zulkarnain, Rif'at; Utami, Ratih Yulistika
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Indonesia is a country with more than 190 million smartphone users. This makes Indonesia the fourth largest smartphone user in the world after China, India, and the United States. Students tend to use smartphones with high intensity. High smartphone use can lead to smartphone addiction. Objective: to analyze the effect of smartphone usage intensity on academic procrastination behavior and learning motivation in students at the University of Muhammadiyah North Sumatra. Method: This research is an analytical study using a cross-sectional method, with a sample of 63 people divided into 7 people each from 9 faculties at the University of Muhammadiyah North Sumatra. The sampling technique uses the Probability Sampling procedure, namely Consecutive Sampling. All samples filled out three questionnaires to measure the intensity of smartphone use, learning motivation, and academic procrastination. The data obtained will be analyzed using univariate and bivariate analysis techniques, then to test the hypothesis using the Spearman test to assess whether there is an influence between the independent and dependent variables. Results: The Spearman correlation test showed that smartphone usage intensity influenced academic procrastination among students at the University of Muhammadiyah North Sumatra, with a correlation coefficient of 0.790 (p-value of 0.001). The correlation coefficient of smartphone usage on learning motivation among students at the University of Muhammadiyah North Sumatra was -0.531 (p-value of 0.001), indicating a strong and negative relationship between the two variables. Conclusion: High smartphone usage intensity will increase academic procrastination, while high smartphone usage intensity will decrease student learning motivation.
Pengaruh Pemberian Ekstrak Rumput Bambu (Lophatherum gracile) sebagai Hepatoprotektor pada Mencit Jantan (Mus musculus) Putra Fauzi, Zidan Imana; Suryani, Des
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: The use of paracetamol in toxic doses can cause impaired liver function. Bamboo grass is a plant that contains antioxidants, so it can be a hepatoprotector in protecting the liver from damage caused by paracetamol. The dose of Lopatherum gracile as a hepatoprotector has been studied in the dose range of 200 mg/kg body weight and 800 mg/kg body weight, with an effective dose result of 800 mg/kg body weight. The purpose of this study was to determine the effective dose of the hepatoprotector of bamboo grass extract against paracetamol-induced liver function in mice. This study is a true experiment with a post-test-only control group design. 5 groups were given treatment for 7 days, namely the negative control group (C-), positive control (C+), treatment 1 (T I): 400 mg/kg body weight, treatment 2 (T II): 600 mg/kg body weight, and treatment 3 (T III): 800 mg/kg body weight.  The SGOT and SGPT levels between groups were analysed by one-way ANOVA and post hoc Bonferroni. The results of the ANOVA test showed a significant difference in the level of SGOT and SGPT, namely p=0.001. The post hoc test showed no significant difference in SGOT and SGPT levels between T(II) and T(III), with negative controls of p:0.242, and p:0.100, and there was no significant difference in average SGOT between T2 and T3. The effective dose of hepatoprotector of bamboo grass extract in a group of paracetamol-induced mice was 600 mg/kg body weight.
The Effect of Mangrove Leaf Extract (Rhizophora apiculata) on Blood Cholesterol Levels of White Mice (Mus musculus) Induced by Egg Yolk Yuliansyah, Putri Ridha; Nurfadly, Nurfadly; Purwiningsih, Emni; Lubis, Humairah Medina Liza
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Cholesterol is the primary sterol in the human body, produced by the liver. While essential, excessive cholesterol can accumulate as plaques in blood vessels. Rhizophora apiculata contains secondary metabolites such as flavonoids, tannins, alkaloids, saponins, and terpenoids, which are believed to influence HDL and LDL levels. This study aims to investigate the effect of Rhizophora apiculata leaf extract on HDL and LDL levels in male white mice (Mus musculus) induced with egg yolk. This true experimental study applied a post-test with a control group design. A total of 36 white mice were divided into six groups, consisting of negative, positive, and treatment groups. Mice were acclimatised for one week, induced with quail egg yolk, and administered Rhizophora apiculata leaf extract for 30 days. Blood HDL and LDL levels were then measured and analysed using One-way ANOVA. The Shapiro-Wilk and Levene’s tests showed p-values 0.05. The One-way ANOVA indicated significant differences in HDL and LDL levels between groups (p0.05). LSD post hoc tests showed treatment groups P1, P2, and P3 differed significantly from the negative control. Rhizophora apiculata leaf extract affects HDL and LDL levels in male white mice induced by egg yolk.
Students' Perceptions of the Causes, Impacts, and Coping Strategies for Academic Procrastination at the Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara Ritonga, Nurul Fitri; Utami, Ratih Yulistika
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Academic procrastination among university students is relatively high and has psychological impacts such as anxiety, depression, and stress. This study aims to determine the perceptions of students at the Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara (FK UMSU) regarding the causes, impacts, and strategies for managing academic procrastination. This study employed a mixed-methods approach with consecutive sampling involving 76 students. The quantitative findings showed that the majority of students, 59, had a moderate level of academic procrastination, while 11 had low and 6 had high levels. There were two categories of external factors (peers and time) and six categories of internal factors (behavioural, cognitive, physical, academic, interpersonal, and affective). Strategies for managing procrastination were classified into individual and group categories. Most FK UMSU students demonstrated a moderate level of academic procrastination. The contributing factors included peers and time management. Internal factors influencing procrastination were mood, motivation, task perception, academic ability, time management, and recreation. The impacts experienced by students covered behavioural, cognitive, physical, academic, interpersonal, and affective domains. Prevention strategies were categorised into individual and group approaches. 
The Relationship Between Elevated D-Dimer Levels And The Incidence Of Ischemic Stroke In Covid-19 Patients At Drs H. Amri Tambunan Regency, Deli Serdang Regency Novani, Dinda Dwi; Surya, Anita; Arifin, Hasanul; Irma, Fani Ade
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Acute ischemic stroke spreads from infected individuals, whether they are already showing symptoms or not. The initial symptom that often appears in infected individuals is fever, with a body temperature between 38.1 and 39°C. The mechanism of stroke in COVID-19 patients is caused by an increase in D-Dimer and fibrinogen, which are part of the coagulation pathway. Coagulation is related to the systemic inflammatory response caused by infection. The purpose of this study was to understand and further examine the relationship between increased D-Dimer levels in ischemic stroke patients infected with COVID-19 at Drs. H. Amri Tambunan Regional Hospital, Deli Serdang Regency. This research method is a retrospective descriptive study using a cross-sectional research design. This study used secondary data derived from medical records of COVID-19 patients with ischemic stroke events at Drs. H. Amri Tambunan Regional Hospital, Deli Serdang Regency. H. Amri Tambunan, Deli Serdang Regency, 2021. The results of the Chi-square test were 0.239 (P-value 0.05), which means there is no significant relationship between increased D-Dimer and the incidence of ischemic stroke and hemorrhagic stroke in COVID-19 patients. The conclusion obtained was that there was no significant relationship between increased D-Dimer and the risk of ischemic stroke in COVID-19 patients.

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