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INDONESIA
Indonesian Journal of Chemistry
ISSN : 14119420     EISSN : 24601578     DOI : -
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
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Articles 16 Documents
Search results for , issue "Vol 13, No 3 (2013)" : 16 Documents clear
QUINOLIN-6-AMINES: SYNTHESIS AND BIOLOGICAL EVALUATION Hament Panwar; Nidhi Chaudhary; Ranjana Dubey; Tilak Ram
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.923 KB) | DOI: 10.22146/ijc.21274

Abstract

Some novel 2-{(chloromethoxy)methyl}thio-N-substituted phenyl-[1,2,4]triazolo[1,5-a] quinolin-6-amines have been derived from 5-bromocoumarin. All the synthesized compounds have been characterized by elemental and spectral (I.R., 1H-NMR, Mass) analysis and evaluated for their antimicrobial, insecticidal and anthelmintic activities.
FORMULATION AND IN VITRO STUDY OF PROPRANOLOL HYDROCHLORIDE CONTROLLED RELEASE FROM CARBOXYMETHYL CHITOSAN-BASED MATRIX TABLETS Hernawan Hernawan; Septi Nurhayati; Khoirun Nisa; A.W. Indrianingsih; Cici Darsih; Muhammad Kismurtono
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.184 KB) | DOI: 10.22146/ijc.21283

Abstract

Formulation and in vitro study of propranolol hydrochloride controlled release from carboxymethyl chitosan-based matrix tablets have been conducted. Formulations with various concentrations of carboxymethyl chitosan 2% (F1), 4% (F2), 6% (F3) were done by wet granulation method. Compatibility test was conducted by XRD and FTIR spectroscopy to determine interaction between propranolol hydrochloride and polymer excipients. Dissolution profiles was obtained through in vitro tests release using simulated gastric fluid (without enzymes, pH 1.2) for the first 2 h and followed by simulated intestinal fluid (phosphate buffer solution without enzyme, pH 7.2) for 2 h remaining. The dissolution profile of each formulation was fitted with five kinetics modeling of drug release (zero order, first order, Higuchi, Peppas-Korsmeyer, and Hixson-Crowell). The compatibility test results showed that formulation caused physical interactions between propranolol hydrochloride and polymer excipient but doesn't make crystallinity nature of propranolol hydrochloride disturbed even after formulation. Dissolution profiles of each formulation showed that controlled release of propranolol hydrochloride from the tablet followed Peppas-Korsmeyer model. It is concluded that carboxymethyl chitosan in appropriate proportions is suitable for formulating propranolol hydrochloride controlled release tablets which exhibit Peppas-Korsmeyer release kinetics.
NEW PYRAN OF AN ENDOPHYTIC FUNGUS Fusarium sp. ISOLATED FROM THE LEAVES OF BROTOWALI (Tinaspora crispa) Elfita Elfita; Munawar Munawar; Muharni Muharni; Suprayetno Suprayetno
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (438.001 KB) | DOI: 10.22146/ijc.21278

Abstract

Endophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are relatively unstudied and a promising source of novel organic natural metabolites exhibiting a variety of biological activities. As a part of our systematic search for new bioactive lead structures from endophytic, the endophytic fungus Fusarium sp. isolated from the leaves of Brotowali (Tinaspora crispa), was cultured for isolation of metabolite. The endophytic fungus was cultivated on 6 L of Potatos Dextose Broth (PDB) medium at room temperature (no shaking) for 8 weeks. The cultures were then extracted with ethyl acetate to afford 9.4 g of residue after removal of the solvent under reduced pressure. The extract was separated into the fractions by column chromatography (CC) on silica gel. The fractions were further separated by silica gel column chromatography to give one compound. The molecular structure was established on the basis of spectroscopic analysis including UV, IR, 1H-NMR, 13C-NMR, HMQC, HMBC, COSY, and MS. The compound was determined as a new pyran.
CHARACTERISTIC OF AIRBORNE PARTICULATE MATTER SAMPLES COLLECTED FROM TWO SEMI INDUSTRIAL SITES IN BANDUNG, INDONESIA Diah Dwiana Lestiani; Muhayatun Santoso; Syukria Kurniawati; Andreas Markwitz
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.133 KB) | DOI: 10.22146/ijc.21287

Abstract

Air particulate matter concentrations, black carbon as well as elemental concentrations in two semi industrial sites were investigated as a preliminary study for evaluation of air quality in these areas. Sampling of airborne particulate matter was conducted in July 2009 using a Gent stacked filter unit sampler and a total of 18 pairs of samples were collected. Black carbon was determined by reflectance measurement and elemental analysis was performed using particle induced X-ray emission (PIXE). Elements Na, Mg, Al, Si, P, S, Cl, K, Ca, Ti, Cr, Mn, Fe, Cu, Zn and As were detected. Twenty four hour PM2.5 concentration at semi industrial sites Kiaracondong and Holis ranged from 4.0 to 22.2 µg m-3, while the PM10 concentration ranged from 24.5 to 77.1 µg m-3. High concentration of crustal elements, sulphur and zinc were identified in fine and coarse fractions for both sites. The fine fraction data from both sites were analyzed using a multivariate principal component analysis and for Kiaracondong site, identified factors are attributed to sea-salt with soil dust, vehicular emissions and biomass burning, non ferrous smelter, and iron/steel work industry, while for Holis site identified factors are attributed to soil dust, industrial emissions, vehicular emissions with biomass burning, and sea-salt. Although particulate samples were collected from semi industrial sites, vehicular emissions constituted with S, Zn and BC were identified in both sites.
SIMULTANEOUS DETERMINATION OF CADMIUM, COPPER AND LEAD IN SEA WATER BY ADSORPTIVE STRIPPING VOLTAMMETRY IN THE PRESENCE OF CALCON AS A COMPLEXING AGENT Deswati Deswati; Hamzar Suyani; Safni Safni; Umiati Loekman; Hilfi Pardi
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.532 KB) | DOI: 10.22146/ijc.21282

Abstract

A selective and sensitive adsorptive stripping voltammetric (AdSV) procedure for the simultaneous determination of cadmium, copper and lead in the sea water was conducted. The aim of this research is to get optimum condition for simultaneous determination of cadmium, copper and lead. Adsorptive stripping voltammetry has been used for determination of trace amount of Cd(II), Cu(II) and Pb (II) by using calcon as a complexing agent. The parameters studied were variation of calcon concentration, pH, accumulation potential and accumulation time. In this study, the optimum conditions were calcon concentration of 0.6 mM, pH = 4.0, accumulation potential of -0.7 V and accumulation time of 80 sec. At the optimum conditions, the relative standard deviation were 8.78%, 3.12%, and 4.02% for Cd(II), Cu(II) and Pb(II) respectively for eight replicates (n = 8) measurements of 10 μg/L mixed standard solution of Cd(II), Cu(II) and Pb(II). The method was applied to the direct simultaneous determination of Cd(II), Cu(II) and Pb(II) in sea water around Bungus, Padang City. Concentration of Cd(II), Cu(II) and Pb(II) in samples were equal to 1.8 μg/L for Cd(II), 38.6 μg/L for Cu(II) and 0.7 μg/L for Pb(II) with recovery of 87.03%, 98.80%, and 95.73%, respectively.
CONVERSION OF THE LOW QUALITY INDONESIAN NATURALLY-OCCURRING MINERALS INTO SELECTIVE TYPE OF ZEOLITES BY SEED-ASSISTED SYNTHESIS METHOD Rino R. Mukti; Shofarul Wustoni; Agus Wahyudi; Ismunandar Ismunandar
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.659 KB) | DOI: 10.22146/ijc.21288

Abstract

An X-ray diffraction (XRD) revealed that Indonesian naturally-occurring mineral from Nanggung, Bogor shows to be a low quality product as it does not seem to contain any zeolite materials. As located in the volcanic area, Indonesia essentially has abundant source of natural zeolites and the country has put much efforts on these treasured materials for export commodity. In order to bring the local natural mineral into high value and to discover whether the mineral has at least zeolitic fragments, we have implemented seed-assisted synthesis to see the possibility of growing zeolite and turn this mineral into high quality. In principle, once the mineral has zeolitic fragment or nuclei, recrystallization of the mineral may occur. By utilizing this mineral as seed in aluminosilicate mother solution, selective mordenite-type (MOR) zeolite can be obtained after hydrothermal treatment. Characterization by XRD showed that this MOR zeolite has high crystallinity and scanning electron microscopy (SEM) depicted the crystal morphology. The natural mineral is conclusively essential for the formation of MOR zeolite by seeding the aluminosilicate mother solution. In the absence of aluminosilicate mother solution, natural mineral can be recrystallized into selective analcime-type (ANA) zeolite. MOR zeolite is known to be useful for several applications such as catalysis whereas ANA zeolite has been considered to be less potential due to relatively small microporosity.

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