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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 25 Documents
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Search results for , issue "Vol 24, No 1 (2024)" : 25 Documents clear
Synthesis of TiO2/ZnO Nanocomposites by the Electrochemical Method and Their Application in Dye-Sensitized Solar Cells (DSSCs) Aqeel Mahdi Jreo Alduhaidahawi; Ali Abdulsalam Ahmed
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.87071

Abstract

Various standard methods have previously been used for the synthesis of nanoparticles that produce unhealthy waste. They are also considered unsafe and expensive methods. An alternative technology is needed to synthesize nanoparticles that consume less energy and are more environmentally friendly. In this research, a TiO2/ZnO nanocomposite has been synthesized, which was produced with efficient energy and no environmental pollution using an easy and fast method (electrochemical). Additionally, dye-sensitized solar cells (DSSCs) have been fabricated from TiO2/ZnO nanocomposite which was synthesized by a new green method and pigments (methylene blue as a chemical dye and chlorophyll as a natural dye). These DSSCs were characterized by their high ability to absorb ultraviolet energy, where the efficiency of energy conversion η of ITO-TiO2/ZnO were approximately 2.08, and 3.04% with chlorophyll and methylene blue, respectively, showing that η of ITO-TiO2/ZnO with methylene blue was the best.
Nanomaterial for Adjuvants Vaccine: Practical Applications and Prospects Vy Anh Tran; Vien Vo; Vinh Quang Dang; Giang Ngoc Linh Vo; Ta Ngoc Don; Van Dat Doan; Van Thuan Le
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.87940

Abstract

Vaccines contain adjuvants to strengthen the immune responses of the receiver against pathogen infection or malignancy. A new generation of adjuvants is being developed to give more robust antigen-specific responses, specific types of immune responses, and a high margin of safety. By changing the physical and chemical properties of nanomaterials, it is possible to make antigen-delivery systems with high bioavailability, controlled and sustained release patterns, and the ability to target and image. Nanomaterials can modulate the immune system so that cellular and humoral immune responses more closely resemble those desired. The use of nanoparticles as adjuvants is believed to significantly improve the immunological outcomes of vaccination because of the combination of their immunomodulatory and delivery effects. In this review, we discuss the recent developments in new adjuvants using nanomaterials. Based on three main vaccines, the subunit, DNA, and RNA vaccines, the possible ways that nanomaterials change the immune responses caused by vaccines, such as a charge on the surface or a change to the surface, and how they affect the immunological results have been studied. This study aims to provide succinct information on the use of nanomaterials for COVID-19 vaccines and possible new applications.
Energy Efficiency of the Carbonate Hydroxyapatite Nanoparticle Synthesis Using Microwave Heating Treatment and Its Effect on Material Characteristics Saifuddin Aziz; Harno Dwi Pranowo; Ika Dewi Ana; Yusril Yusuf
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.88155

Abstract

This work aimed to study the energy efficiency of the synthesis process of carbonated hydroxyapatite (CHA) nanoparticles using microwave heating treatment and its effect on material characteristics. Microwaves can provide heat quickly, so it is expected to increase the efficiency of CHA synthesis through the heat provided. The CHA nanoparticles were synthesized using precipitation and heated using a microwave oven. The unheated and hydrothermal-heated precipitation methods were also conducted for comparison purposes. The microwave-heated precipitations were done at 270 W for 0.05, 0.10, and 0.15 h, while the hydrothermal-heated precipitations were done at 100 °C for 1, 2, and 3 h. The CHA materials were characterized using an infrared spectrophotometer, X-ray diffractometer, and electron microscope. The X-ray diffractogram and infrared spectra confirmed that the synthesized materials had a hydroxyapatite crystal phase with a CO32− functional group in their spectra. Microscopic images revealed that the materials were nanometer-sized grain aggregates. The heat treatment and duration increased the material characteristics, i.e., crystallinity, crystallite, and grain size. The CHA with microwave heat treatment had the highest crystallinity and crystallite size. The electrical energy calculation revealed microwave heating had better energy efficiency than hydrothermal heating.
Molecular Docking and Molecular Dynamic Investigations of Xanthone-Chalcone Derivatives against Epidermal Growth Factor Receptor for Preliminary Discovery of Novel Anticancer Agent Yehezkiel Steven Kurniawan; Ervan Yudha; Gerry Nugraha; Nela Fatmasari; Harno Dwi Pranowo; Jumina Jumina; Eti Nurwening Sholikhah
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.88449

Abstract

Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has been known as a common target for the initial screening of new anticancer agents. Either xanthone or chalcone has been evaluated as the anticancer agents, and their activity strongly depends on the type and position of the attached functional group. Therefore, molecular hybridization between xanthone and chalcone could yield novel anticancer agents through the EGFR inhibition mechanism. Herein, a series of xanthone-chalcone derivatives with hydrogen-bond-acceptor or hydrogen-bond-donor substituents at ortho, meta, and para positions was evaluated as the EGFR inhibitor. Thirty-seven xanthone-chalcones were designed and docked in the active site of EGFR. Compared to the native ligand, pristine xanthone-chalcone gave a 1.215× stronger binding energy and a 13.97× lower binding constant. Compound 3SH was found to be the most promising candidate due to its strongest binding energy (−9.71 kcal/mol) and the lowest binding constant (0.08 µM). Furthermore, molecular dynamic studies demonstrated that complex EGFR-3SH was stable for 100 ns simulation. These in silico investigations show that the xanthone-chalcone derivative is a promising novel anticancer agent to be examined through in vitro and in vivo assays.
Recent Advancement and Emerging Applications of Lignin Tanu Mittal; Rishi Kant; Yogesh Bhalla; Mohit Kumar Goel
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.88535

Abstract

Lignin is a significant renewable natural energy resource these days, used as an environmentally acceptable and sustainable alternative fossil fuel feedstock in a huge possibility of value-added products. Lignin is a polymeric molecule that possesses an aromatic unit structure, together with cellulose, and is a main component of the cell walls of plants. It is the byproduct of agriculture residues and biorefinery products and can be extracted from paper-pulp industries. Properties of lignin may differ depending on the extraction method and source and also on an aromatic ring as the main constituent of lignin in the structure. This rare composition of lignin makes it more valuable, allowing for value-added applications such as in the field of storage devices and energy harvesters. This review focuses on derivatives of lignin, structure and composition sources and characteristics, and its sustainable emerging application in various fields are discussed.

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