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Kota semarang,
Jawa tengah
INDONESIA
MEDIA MEDIKA INDONESIANA
Published by Universitas Diponegoro
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
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Articles 12 Documents
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Search results for , issue "2011:MMI Volume 45 Issue 3 Year 2011" : 12 Documents clear
Risk Factors of Stunting among 1-2 Years Old Children in Semarang City Aryu Candra; Niken Puruhita; JC Susanto
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACTBackground: Prevalence of stunting in children under five years in Central Java is high, more than 33%. Semarang City has high prevalence of malnutrition therefore there is a need to identify risk factors of stunting in Semarang city.Method: This was a case control study, completed with qualitative study about risk factors of stunting. Samples were 58 cases and 58 controls. Data were analyzed by univariate analysis, bivariate analysis with chi square test, and multivariate analysis with multiple logistic regression. Qualitative study was done by using indepth interview, and presented in narration.Results: The multivariate analysis result showed that risk factors of stunting in children 1-2 years old were short stature father (<162 cm) (p=0.016; OR=2.7; CI=1.2-6), children had history of low birth weight (p=0.028; OR=11.2; CI=1.3-96.3), and children had history of underweight (p=0.006; OR=3.3; CI=1.4-7). Risk factors which were not proven to influence the incidence of stunting were maternal height, history of exclusively breastfed, complementary feeding history; sex, history of infection, and immunization history.Conclusions: Risk factors that influence the incidence of stunting in children 1-2 years olds are having father’s height <162 cm, and positive history of low birth weight, and of underweight.Keywords: Stunting, malnutrition, children, growth, risk factorsABSTRAKFaktor risiko dari stunting pada anak usia 1-2 tahun di kota SemarangLatar belakang: Stunting adalah perawakan pendek yang timbul akibat malnutrisi yang lama. Prevalensi stunting pada balita di Jawa Tengah tinggi, yaitu lebih dari 33%. Kota Semarang merupakan ibukota Jawa Tengah yang memiliki prevalensi malnutrisi cukup tinggi sehingga diperlukan studi untuk mengetahui faktor risiko stunting di Kota Semarang.Metode: Penelitian ini merupakan studi kasus kontrol, dilengkapi kajian kualitatif mengenai stunting pada status ekonomi kurang dan status ekonomi cukup. Jumlah sampel 58 kasus dan 58 kontrol. Analisis data dilakukan secara univariat, bivariat dengan chi square test, multivariat dengan metode regresi logistik ganda. Kajian kualitatif denganmetode indepth interview dan disajikan dalam bentuk narasi.Hasil: Hasil analisis multivariat menunjukkan faktor risiko yang berpengaruh terhadap kejadian stunting pada anak 1-2 tahun di kota Semarang adalah tinggi badan ayah <162 cm (p=0,016; OR=2,7; CI:1,2-6), anak yang mempunyai riwayat BBLR (p=0,028; OR=11,2; CI=1,3-96,3), dan anak mempunyai riwayat underweight (p=0,006; OR=3,3; CI=1,4-7). Faktor risiko yang tidak terbukti mempengaruhi kejadian stunting adalah jenis kelamin, tinggi badan ibu, riwayat ASI eksklusif, riwayat infeksi, riwayat imunisasi, dan riwayat makanan pendamping ASI.Simpulan: Faktor risiko yang mempengaruhi kejadian stunting pada anak 1-2 tahun adalah yang mempunyai ayah dengan tinggi badan <162 cm dan mempunyai riwayat BBLR, serta berat badan kurang.
Sumbangan All-Trans Asam Retinoat (ATRA) Bagi Penyembuhan Periodontitis Praptiwi Praptiwi; Siti Fatimah Muis; Soeharyo Hadisaputro; Suryono Suryono
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACTAll-trans retinoic acid (ATRA) contribution to periodontitis healingBackground: In inflammation and infection of periodontal ligament i.e periodontitis, collagen fiber is damaged. All-trans retinoic acid (ATRA), metabolite of vitamin A, has potency to depress damage in inflammation. Indonesia with high vitamin A deficiency, facing to delayed recovery of periodontitis. The disease is vastly suffered by common people in this country. The study aimed to know the collagen status of periodontal ligament suffering periodontitis treated with tetracycline and ATRA supplementation.Method: The experimental study using post test only design in 12 adult male Wistar rat was done in 7 days. The animal study were induced periodontitis through Porphyromonas gingivalis inoculation. Tetracycline 90 mg/kg was given, beside ATRA supplementation of 10 mg/kg and 5 mg/kg. Four experimental groups were chosen randomly. Group of periodontitis + tetracycline was the control of the study. The independent variables were ATRA supplementation of those high and low dose. The dependent variable was collagen status. Collagen status consist of degradation and synthesis of collagen, indicated by mRNA MMP-2 and mRNA P1CP respectively. They were measured by reversed transcriptase polymerizing chain reaction and thin layer chromatography. All-trans retinoic acid concentration was measured using high performance liquid chromatography. The dataanalyzed using t-test, Oneway ANOVA, post hoc duncan and least significant differences.Result: In group receiving 10 mg ATRA/kgBB, the ATRA level was highest but the collagen degradation was lower although not significant compared to the low dose ATRA group. In both groups the degradation was significantly lower than the control group (p=0.007). The synthesis of collagen in the low dose ATRA group was higher than the high dose ATRA group and the control group.Conclusion: High dose of ATRA supplementation contribution to less degradation of collagen, but in term of collagen synthesis, low dose ATRA supplementation gives better result.Keywords: ATRA supplementation, collagen degradation, periodontitis ABSTRAKLatar belakang: Pada peradangan dan infeksi kronik ligamentum periodontal yaitu periodontitis, terjadi kerusakan serat kolagen. All-trans asam retinoat (ATRA), metabolit vitamin A, berpotensi menekan kerusakan pada peradangan. Tingginya defisiensi vitamin A di Indonesia, menghambat proses penyembuhan periodontitis yang banyak diderita masyarakat luas. Penelitian bertujuan mengetahui status kolagen ligamentum periodontal periodontitis yang mendapat pengobatan tetrasiklin dan suplementasi ATRA.Metode: Studi eksperimental dengan rancangan post test only pada 12 tikus Wistar jantan dewasa telah dilakukan selama 7 hari. Hewan coba diinduksi periodontitis melalui inokulasi bakteri Porphyromonas gingivalis. Diberikan tetrasiklin 90 mg/kg, juga suplementasi ATRA 10 mg/kg dan 5 mg/kg. Empat kelompok studi dipilih secara acak. Kontrol adalah kelompok sakit + tetrasiklin. Variabel bebas adalah suplementasi ATRA dosis tinggi dan dosis rendah, variabel tergantung adalah status kolagen. Status kolagenmencakup degradasi dan sintesis, berturut-turut dengan petanda mRNA MMP-2 dan mRNA P1CP, diukur menggunakan reverse transcriptase polymerizing chain reaction dan thin layer chromatography. Kadar ATRA diukur dengan high performance liquid chromatography. Data dianalisis dengan uji t, Oneway ANOVA, post hoc Duncan dan least significant differences.Hasil: Pada kelompok yang menerima suplementasi ATRA 10 mg/kgBB kadar ATRA tertinggi, tetapi degradasi kolagennya lebih rendah walau tidak bermakna. Kedua kelompok sumplementasi degradasi kolagennya lebih rendah secara bermakna dibanding kelompok kontrol (p=0,007), dalam sintesis kolagen,kelompok yang mendapat suplementasi ATRA 50 mg/kgBB sintesisnya lebih baik dibanding kelompok yang mendapat ATRA 10 mg/kgBB maupun kelompok kontrol.

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