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INDONESIA
ACI (Acta Cardiologia Indonesiana)
Published by Universitas Gadjah Mada
ISSN : 24605700     EISSN : 25794345     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ACI (Acta Cardiologia Indonesiana) is published twice a year (biannually) by the Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 1, No 2 (2015)" : 7 Documents clear
Epidemiological Profile of Congenital Heart Disease in a National Referral Hospital Muhamad Taufik Ismail; Fera Hidayati; Lucia Krisdinarti; Noormanto Noormanto; Sasmito Nugroho; Abdul Samik Wahab
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17811

Abstract

Introduction: Sardjito Hospital is the tertiary referral hospital in Yogyakarta and Central Java, Indonesia. There are no reported data measuring epidemiological profi le of congenital heart disease (CHD) in this region. This study was aimed specifi cally to determine the most major lesion and type of CHD in one of an over-populated area in Indonesia. Methods: The retrospective observational study was conducted during January 2014 to December 2014 in Sardjito Hospital. In and outpatients with CHD taken from medical record were noted their clinical data and only patients with transthoracal echocardiographic proof of CHD were included in this study. CHD with more than single lesion was simplifi ed as one lesion which had most major impact on hemodynamic circulation. The denomerator was the sum of all new patients visiting to the hospital at 2014. Data were entered in MS-excel and analyzed by software SPSS version 22.Results: We had total 650 new patients with CHD registered to Sardjito Hospital in 2014. The incidence of CHD was 134/10.000 person-years consisted of adult 22% and children 78% (female 60% and male 40%). Ventricle septal defect (VSD) was the most common lesion among children (30%) followed by atrial septal defect (ASD) 17%, persistent ductus arteriosus (PDA) 16%, andTetralogy of Fallot (TOF) 7%. Meanwhile in adult, ASD was the most frequent CHD (60%), continued by VSD 23%, TOF 8%, and PDA 4%. Secundum, primum, and sinus venosus type were found in 94%, 3%, and 3% of total ASD in children, and 99%, 1%, and 0% of adult respectively. Perimembran outlet (PMO), doubly committed subarterial (DCSA), and inlet were found in 66%, 12%, and 12% of total VSD in children, and 39%, 54%, and 0% of adult respectively. TOF had the highest incidence of cyanotic heart diseases (33 cases, 7%) in children and also in adult (12 cases, 8%). Conclusion: The incidence of CHD was 134/10.000 person-years. The most common lesion among children was VSD and in adult was an ASD. TOF had the highest incidence of cyanotic heart disease among children and adult. Secundum type was the most common fi nding in all ages of ASD population, whereas PMO and DCSA were the most frequent type of VSD in children and adult respectively.Keywords: incidence, congenital heart disease, hospital, cyanotic, type
Electrical and Mechanical Activity of The Heart Erdiansyah Zulyadaini; Hariadi Hariawan; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17812

Abstract

The regularity and rhythm of contraction of the heart muscles (myocardium) depends on how electrical impulses spreads through the conduction system organized. The process is initiated by electrical stimulation which thencauses depolarization. Depolarization is a series of ion transfer through channels that are specifi c to myocardial cell membrane (sarcolemma). These canals spread across the sarcolemma, which include:the Na+ channels, Ca2+ channels, channelK+, Na+-Ca2+exchanger, Na+-K+-ATPase pump and Ca2+active pump. The infl ux of Na+ ions into cell will start depolarization and then spread through conduction system to the rest of the myocardium.
Efficacy of Lumbrokinase and Warfarin Compared to Single Warfarin on Thrombus Resolution in Deep Vein Thrombosis Anggia Endah Satuti; Hariadi Hariawan; Hasanah Mumpuni
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17798

Abstract

Background: Deep vein thrombosis (DVT) is a challenging condition for clinician in all specialities. Prognosis after vein thromboembolism is worse and much worse after pulmonary embolism. Anticoagulant is the mainstay therapy for deep vein thrombosis, but there is still slow thrombus resolution even with the use of optimal anticoagulant. The use of intravenous thrombolytic agentsis one of the methods to signifi cantly lyse thrombus. Since there is increasing risk of bleeding with the use of the agents, indication is limited. Lumbrokinase is oral thrombolytic that may give significant thrombus lyses without increasing the risk of bleeding for deep vein thrombosis. This study was conducted to compare single warfarin therapy with combination of lumbrokinase andwarfarin for thrombus resolution in deep vein thrombosis patients. Methods: This study was a randomized open labeled trial comparing deep vein thrombosis patients using single warfarin therapy group to group using combination lumbrokinase and warfarin. 22 patients meet the inclusion and exclusion criteria. Patients were followed for 30 days and in the end of the trial, evaluation using vascular Doppler ultrasonography was done. Chi-square analysis was used to compare the outcome between two therapy groups. Results: In this trial, group therapy with added lumbrokinase to warfarin yielded a tendency toward better thrombus resolution compared to group with single warfarin therapy (58.3% vs.30%, p=0.231). Conclusion : Added therapy with lumbrokinase to warfarin may give better thrombus resolution as compared to single warfarin therapy, although there is no signifi cant difference between groups.Keywords: deep vein thrombosis, lumbrokinase, warfarin
Ventricular Septal Defect Closure with Perforated Patch in Large Ventricular Septal Defect with Severe Pulmonary Hypertension and Non Reactive Oxygen Test Budi Yuli Setianto; Hariadi Hariawan; Rano Imawan
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17813

Abstract

Management of ventricular septal defect (VSD) with severe pulmonary hypertension (PH) had not been extensively studied and is still challenging. The closure of VSD in patients with high pulmonary vascular resistance (PVR) and severe PH is highly risk procedure. If high PVR and severe PH still persist after closure procedure, the patients have poor prognosis. We reported a 24-year-oldwoman whom was diagnosed with large VSD, bidirectional shunt with L to R dominance, dilatation of left ventricle, and mild to moderate mitral regurgitation, mild tricuspid regurgitation and severe PH. Right heart catheterization showed pre-oxygen test: mean aorta pressure 85 mmHg, mean pulmonary artery pressure 65 mmHg, fl ow ratio 5,4, PVR 2,3 WU and pulmonary vascular resistance index (PVRI) 3,22 WU/m2. The results of post-oxygen test: mean aorta pressure 83 mmHg, mean pulmonary artery pressure 63 mmHg, fl ow Ratio 2,2, PVR 0,3 WU and PVRI 0,42 WU/m2. Patient had been performed VSD closure with perforated patch 3 mm. Three month evaluation by echocardiography showed residual VSD 3 mm, L to R shunt, moderate tricuspid regurgitation and mild PH (TVG 36 mmHg). In Baumgartner criteria of VSD operability, this patient was not operable because the ratio of mean pulmonary and systemic circulation more than 2/3, but in Lopez criteria, patient is operable because PVRI below 6 WU/m2. Patient with high and moderate PH and PVR which is still operable, VSD can be closed partially. Partially VSD closure can be performed by transcatheter procedure after PH decrease and stable.Keyword: VSD closure- perforated patch – PH severe
High Apo B/Apo A-1 Serum Ratio As a Predictor of in-Hospital Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients Diyantie Saputri; Hariadi Hariawan; Bambang Irawan
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17799

Abstract

Background: An increased level of apo B and decreased level of apo A-1 are thought to be better predictors of myocardial infarction than conventional lipid parameters in healthy individuals and/ or have coronary artery disease risk factors. Literatures said that HDL, LDL and apolipoprotein may have a role in haemostatic and thrombotic process. The present study aimed to investigate whether apo B/ apo A-1 ratio has a predictive role in hospitalised ACS patients to develop major adverse cardiac events (MACE). Methods: We performed a prospective cohort study and examined 182 ACS patients hospitalised in dr. Sardjito General Hospital Yogyakarta consecutively since September 2013, and evaluated ischaemia heart disease risk factors, measured concentration of apo B/apo A-1 ratio and conventional lipid parameters from plasma, and finally assessed the in-hospital MACE outcome. Apo B/Apo A-1 ratio cut off point in this study was taken from ROC curve analysis. Relation between in-hospital MACE with level of apo B/apo A-1 ratio was analysed using SPSS. Results: From 182 ACS subjects, 51 patients had MACE (MACE group) and 131 patients didn’t develop MACE (non-MACE group). From ROC curve, we set cut off point for apo B/apo A-1 ratio was 0,865. Subjects with an apo B/apo A-1 ratio ≥0,865 had a signifi cantly increased risk to suffer a cardiovascular event (MACE) during in-hospital follow-up. In a multiple logistic regression model, elevated apo B/apo A-1 ratio was an independent predictor for MACE during in-hospital follow-up (OR 3,17; 95%CI 1,299 - 7,738; p = 0,011). Conclusion: The results showed that the elevated apo B/apo A-1 ratio ≥0,865 was an independent predictor of MACE, with three-folds increase of risk compared to group of apo B/apo A-1 ratio < 0.865, during in-hospital follow-up in ACS patients.Keywords: apolipoprotein B; apolipoprotein A-1; apolipoprotein ratio; acute coronary syndrome; major adverse cardiovascular events
Common Atrium in Ellis Van-Creveld Syndrome Kartika Apshanti; Irsad Andi Arso; Bambang Irawan
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17814

Abstract

Single atrium is a complete absence of atrial septum.1 It is often found in Ellis-van Creveld Syndrome. Ellis-van Creveld Syndrome is a chondral and ectodermal dysplasia that is characterized by short ribs, polydactyly, growth retardation and also ectodermal and heart defects. We report a male, 18 years old who came with worsening of dyspnea. At physical examination we found short stature, polydactyly, cardiomegaly, severe scoliosis, genu valgum and nail hypoplasia. Transthoracic echocardiography showed the complete absence of atrial septum with signs of pulmonary hypertension.Keywords: common atrium, Ellis-van Creveld Syndrome, polydactyly
Diagnostic Performance Addition of Abnormal P Wave Dispersion on Moderate Risk Duke Treadmill Score Criteria in Detecting Severe Stenosis of Coronary Arteries in Stable Angina Pectoris Patients Widodo Darmo Sentono; Erika Maharani; Irsad Andi Arso
ACI (Acta Cardiologia Indonesiana) Vol 1, No 2 (2015)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.17810

Abstract

Background: Moderate risk Duke treadmill score (DTS) in threadmill test (TMT), needs additional diagnostic tool to increase its sensitivity of detecting severe coronary artery stenosis in patients with stable angina pectoris. A P wave dispersion (PWD) during TMT currently has a significant relationship with DTS value and can increase the sensitivity in identifying an ischemia. This studyaimed to investigate whether the addition of PWD in moderate risk DTS can improve the prediction of the severity of coronary artery stenosis in patients with stable angina pectoris. Methods: This study is a diagnostic test with cross-sectional design. The subjects were patients who had undergone TMT and coronary angiography at the Dr. Sardjito General Hospital Yogyakarta. The outcomes were sensitivity and specifi city of abnormal PWD in moderate risk DTS patients for predicting the severe stenosis in those with stable angina pectoris as compared with moderate risk DTS and normal PWD.Results: The additional of PWD at moderate risk DTS on 64 subjects had a sensitivity of 86.7%, a specifi city of 44.1%, a positive predictive value of 57.8%, a negative predictive value of 79.0%, a positive likelihood ratio of 1.6, a negative likelihood ratio of 0.3 and a prevalence of 46.9%, witha prediction accuracy of 64.1%. Conclusion: The additional of abnormal PWD in moderate risk DTS had a sensitivity of 86.7% and a specificity of 44.1% for severe coronary artery stenosis in patients with angina pectoris.Keywords: P wave dispersion, moderate risk Duke treadmill score, severe coronary stenosis.

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