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Maternal Mortality and Contributing Risk Factors
Bazar, Abi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.278
Objectives: Maternal mortality is one indicator to assess a nation’s health care quality. This research was conducted to determine the determinant risk factors for maternal mortality.
Methods: A retrospective case control study at Dr. Mohammad Hoesin General Hospital for 5 years, with 200 samples consists of 50 cases of maternal mortality and 150 physiological labor cases as control group.
Results: For 5 years, there was 109 cases of maternal mortaliy. Of the 50 samples of maternal mortality cases, the most common cause were preeclampsia/eclampsia (50%), followed by hemorrhage (28%). The risk factors were categorized as distant, intermediate, and outcome factors, as stated by McCarthy et al. On bivariate analysis,
we found the significance on maternal education and husband’s occupation (distant factors), residence, referral status, numbers of ANC visits, first attendant, labor facility and history of prior medical history (intermediate factors), and also modes of delivery and complications (outcome factors). On the multivariate analysis to determine
the most contributing risks factors for maternal mortality, it was found that maternal education and residence were the most influencing factors for maternal mortality (OR 5.74 and 4.65 respectively; p=0.001).
Conclusions: The most contributing risks factors for maternal mortality were maternal education and residence.
[Indones J Obstet Gynecol 2012; 36-1:8-13]
Keywords: case control study, maternal mortality, risk factors.
Malaria Detection using Polymerase Chain Reaction (PCR) Method in Pregnant Women’s Saliva on Several Hospitals in North Sulawesi Province
Khrisnamurti, Dewanto
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.279
Objective: To detect malaria by PCR examination of saliva in pregnant women and to obtain the incidence of malaria and the type of plasmodium causing malaria in pregnant women at various hospital in North Sulawesi.
Method: A descriptive cross sectional study in pregnant women during antenatal care at the Department of Obstetrics and Gynecology Faculty of Medicine University of Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital in Manado, R.W. Monginsidi Hospital in Manado, Bethesda Hospital in Tomohon, and Datoe Binangkang Hospital in Kotamobagu, from 1 April until 31 May 2008.
Result: There were 43 pregnant women clinically diagnosed with malaria, 23 (53.49%) by PCR examination of saliva and 20 (46.59%) by blood smears. From 23 cases of malaria in pregnancy detected by PCR, there were 18 diagnosed as tropical malaria, 3 tertian malaria, and 2 mixed malaria.
Conclusions: The incidence of malaria in pregnancy at various hospital in North Sulawesi using PCR methods for saliva examination from April 1 - May 31 2008 is 53.49%. In this study malaria are mostly caused by Plasmodium falciparum with the largest incidence in primigravida, in the first trimester.
[Indones J Obstet Gynecol 2012; 36-1:14-9]
Keywords: malaria, PCR, pregnancy, saliva
The Identification of Placental Alpha Micro Globulin-1 (Amnisure®) as a Method to Identify Rupture of Membrane
Wirawan, Jimmy P.
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.280
Objective: We aimed to do a study in the use of the identification of Placental Alpha Micro Globulin-1 or PAMG-1, in the form of Amnisure ® test, as a method to diagnose rupture of membrane (ROM), compared with other conventional method (direct visualization and
nitrazine test).
Method: We used a cross-sectional design. Every pregnant woman who came to our hospital with gestational age of 14 to 42 weeks complaining of membrane rupture was recruited. Sterile speculum
examination and nitrazine test was performed for every patient. Amnisure ® was utilized, using vaginal swab from posterior fornices. Data analysis was performed with SPSS version 17.
Results: We recruited 20 patients to join our study. Mean age, parity and gestational age was 28.5 years, parity one and 35.5 ± 3.4 weeks of gestation. Amnisure® test was positive in 14 patients. With nitrazine as standard for ROM diagnosis, the sensitivity for Amnisure® was 85% and the specificity was 83.3%. The positive predictive
value was 92.3% and negative predictive value was 71.4%.
Conclusion: For every positive vaginal pooling, nitrazine and Amnisure ® will be tested positive. Several studies using Amnisure® have shown similar results. Role of Amnisure® seemed evident in cases of uncertainty such as chronic ROM and severe oligohydramnios due to ROM. Positive results in presence of intact membranes which suggested micro-perforations of the membrane still need further research. Much still needed to be done before implementing Amnisure® in our country, especially in the matter of cost effectiveness.
[Indones J Obstet Gynecol 2012; 36-1:20-3]
Keywords: amnisure®, PAMG-1, ROM
Neonatal Haemoglobin and Haematocrit Level on Delayed Cord Clamping
Astrianti, LitaLIta R.
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.281
Objectives: To assess neonatal haemoglobin and haematocrit level during delayed cord clamping on normal delivery.
Methods: This was a randomised control trial with simple random sampling method. During March until June 2011, we collected blood sample from venous umbilical cord on newborn baby. Twenty babies were assigned to the first group, of which the clamping of the umbilical was delayed until 2 minutes (DCC). The other 20 babies were assigned to the second group, of which the clamping of the umbilical
was performed as early as 10 second (ECC) after delivery of the whole body of the baby. The haemoglobin and haematocrit level was noted and compared between two groups using Mann-Whitney U test in SPSS 16 for Windows.
Result: There were no difference on maternal characteristic between two groups, except for the maternal education and maternal economic status. The median neonatal haemoglobin level on DCC group was 15.77 g/dl and on ECC group was 14.36 g/dl. There was
statically significant higher neonatal haemoglobin level on DCC group (p=0.005). The median neonatal haematocrit level was 44.1% on DCC group and was 43.35% on ECC group. There was no difference on neonatal haematocrit level between two groups (p=0.652).
Conclusion: Delaying cord clamping until at least two minutes after delivery could increase haemoglobin level on newborn babies. Therefore, this method was suggested for every delivery in area where there is a risk of anemia in neonates such as Indonesia.
[Indones J Obstet Gynecol 2012; 36-1:24-7]
Keywords: delayed cord clamping, haemoglobin, haematocrit
Comparison between Vacuum and Forceps Extraction to Neonatal outcome on Prolonged Second Stage of Labor
Syamsuri, Kurdi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.282
Objective: To assess the effectiveness of vacuum and forceps extraction in prolonged second stage in Dr. Mohammad Hoesin Hospital Palembang.
Methods: A retrospective study for 5 years (2005-2009) by doing a prognostic test on prolonged second stage of labor.
Results: The subject age most commonly ranges from 20 to 35 years (84.8% in the forceps extraction group and 86% in the vacuum group). The common parity was nulliparity (58.1% in the forceps extraction group and 61.58% in the vacuum extraction). In the forceps
extraction group, 76.7% scores >7 in the 1 minute APGAR score with the mean score of 7.14±1.62, whilst in the vacuum extraction group, 79.1% scores >7 in the 1 minute APGAR score, with the mean score of 7.16±1.78. And in the forceps extraction group, 94.2 scores >7 in the 5 minute APGAR score with mean score of 8.62±1.11, whilst in the vacuum extraction group, 93% scores >7 in the 5 minute APGAR score with the mean score of 8.65±1.08. It is concluded that there is no significant differences on both 1 and 5 minute APGAR scores (p value is 0.713 and 0.755, respectively). Maternal complication of extended
episiotomy and perineal rupture were found more often in forceps extraction, but with no statistically significant difference (p=0.324).
Conclusion: There is no difference of effectiveness between forceps extraction and vacuum extraction in the case of prolonged second stage. Physicians are free whether to use the vacuum or foceps according to their own desirability and skill.
[Indones J Obstet Gynecol 2012; 36-1:28-31]
Keywords: forceps extraction, prolonged second stage, vacuum extraction
The Effect of Polymorphisms of Estrogen Receptor βRS1271572 to the Incidence of Epithelial Ovarian Carcinoma
Indrasari, Dwi S.
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.283
Objective: To determine the effect of polymorphism of estrogen receptor β to the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang
Methods: This population-based case control study included 40 women with epithelial ovarian carcinoma and 40 controls, from January 2010 until December 2011. Data analysis was performed by Chi Square test.
Results: Distribution of estrogen receptor beta genotypes, both GT and TT (wild type-mutant and mutant), among case subjects was significantly higher than control (24 subjects {60%} vs. 5 subjects {12.5%}). The genotype effect was statistically significant for rs1271572 (OR=2.636; p=0.039) with Chi Square analysis. Whereas
the allotype effect was also statistically significant (OR=1.949; p= 0.047).
Conclusion: Polymorphism of estrogen receptor β may play a role in the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang.
[Indones J Obstet Gynecol 2012; 36-1:32-6]
Keywords: epithelial ovarian carcinoma, polymorphism of estrogen receptor β, risk factor of ovarian carcinoma
Level of Education as the Determinant Factor of Obstetric Outpatients’ Knowledge about Intra Uterine Device in Kramat Jati Public Health Center
Prabu, Dhika
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.285
Objective: To know the main factor affecting the knowledge of obstetric outpatients about intra uterine device (IUD).
Method: This is across sectional study involving 106 subjects who were selected by a consecutive random sampling in obstetric outpatients clinic, Kramat Jati Public Health Center, Jakarta. Data were obtained from guided questionnaire. There are several dependent variables,
including the knowledge level of respondents toward IUD.
Meanwhile, there are also independent variables, including education level, job, number of children, history of contraception use, and sources of information. The knowledge score >60% is considered good. Afterwards, the data was evaluated with multivariate analysis
with binary logistic regression.
Result: The study found association between the rate of knowledge with the level of education (p=0.015) and history of contraceptive usage (p=0.022). In multivariate analysis, it appeared that education level was the determinant factor, with the rate of low knowledge 2.6 times higher in the low education group.
Conclusion: Level of education are the determinant factor of obstetric outpatients’ knowledge about intra uterine device in Kramat Jati Public Health Center.
[Indones J Obstet Gynecol 2012; 36-1:43-7]
Keywords: IUD, knowledge, level of education
Manual Reposition of Uterine Inversion with Hemorrhagic Shock in Minimal Facilities Situation
Retnoningrum, Endah
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.286
Objective: Reporting management of acute uterine inversion with hemorrhagic shock in minimal facilities situation.
Method: Case report.
Results: Manual reposition in acute uterine inversion was a lifesaving treatment. The decision to do manual reposition with minimal sedation and without any tocolytic could be done in this case, due to minimal facilities situation where there is no operating theater available for ideal uterine reposition.
Conclusion: Uterine inversion can be promptly recognized in the third stage of parturition. Manual manipulation aided by tocolytic with or without anesthetic agents is often successful in correcting the inversion. Shock condition that accompanied the inversion must be vigorously treated, as it would lead to serious maternal morbidity and mortality. Management of acute uterine inversion seems to be depended on the clinical situation and clinical judgment which is very important in every emergency case.
[Indones J Obstet Gynecol 2012; 36-1:48-51]
Keywords: hemorrhagic shock, manual reposition, minimal facilities situation, obstetric complications, uterine inversion
Acute Toxicity and Outcomes of Radiation Alone Versus Concurrent Chemoradiation for Locoregional Advanced Stage Cervical Cancer
Gunawan, Rudy
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.284
Objective: To evaluate and determine the toxicity and outcomes in patient receiving radiation (RT) alone versus concurrent chemoradiation (CRT) using cisplatin for locoregional advanced cervical cancer in Dr. Cipto Mangunkusumo Hospital (RSCM).
Methods: Simple randomized single-blind clinical study, done during the period of November 2010-April 2011, in 32 patients with locoregional advanced cervical cancer (16 were treated RT alone and the rest is treated with CRT). Teletherapy was administrated using 60Co Gamma Rays 1.3 MV and photon beam linear accelerator 4-10 MV. The radiation was administered as much as 2.0 Gy per fraction
daily for 5 days/week, for the total of 25 fractions. Brachytherapy was performed using HDR after-loading method, with Microselectron plane radiation source 129I, as much as 3x7 Gy doses to point A. CRT using cisplatin 30 mg/m2 were given for 5 series during the radiotherapy
course. The toxicity assessments were carried out each
week, up until 3 months after the therapy was deemed completed based on the RTOG and ECOG criteria.
Results: We acquired 100% complete response in both the CRT and RT groups. In the CRT group, we found acute gastrointestinal toxicity grade 3 (18.75%) and grade 2 (43.75%); acute genitourinary toxicity grade 3 (25%), grade 2 (31.25%); and acute hematological toxicity
grade 3 (12.50%) and grade 2 (25%). It is contrasted with the RT group, in which we did not found any cases of acute gastrointestinal toxicity, genitourinary or acute hematologic toxicity. The overall time treatment (OTT) of 56-58 days in CRT and RT group were 25% vs. 81.25% respectively, and the OTT of 59-70 days in CRT and RT
group were 75% vs. 18.75%, respectively.
Conclusion:The response to CRT and RT for locoregional advanced cervical cancer was not different in 3 month evaluation. Acute gastrointestinal, genitourinary, and hematologic toxicities found in CRT were higher than in RT (p=0.000; p=0.000; p=0.002).
[Indones J Obstet Gynecol 2012; 36-1:37-42]
Keywords: acute toxicity, concurrent chemoradiation, locoregional advanced stage cervical cancer, response therapy
The Correlation between Calcium Serum and Calcium Urine Level with the Blood Pressure in Preeclampsia
Deni W. Suryono
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v36i1.277
Objective: To analyze the differences of calcium serum and calcium urine level in preeclampsia and normal pregnancy, and to analyze the correlation between calcium serum and calcium urine level with blood pressure. Method: This study is a cross sectional study with 44 women with preeclampsia and 45 women with normal pregnancies, that meet our inclusion criteria. The samples were obtained from Dr. Hasan Sadikin Hospital and six satellite hospitals from June to September 2011. The comparison of mean calcium serum and calcium urine level of the preeclampsia group was calculated using Mann-Whitney test, and the correlation between calcium serum and calcium urine level and preeclampsia were calculated using Rank Spearman correlation test. Result: The result of the characteristic test in two groups of study shows that both groups are homogenic and comparable. The mean of calcium serum level in women with preeclampsia (7.97 mg/dl) is lower than in normal pregnancy (8.82 mg/dl) with p