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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 36 Documents

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Search results for , issue "Volume. 36, No. 3, July 2012" : 36 Documents clear

Severe Complication of Uterine Perforation and Ileum Prolapse after Having Unsafe Abortion Pradana, Aryando
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Discuss complication after unsafe abortion and management of uterine perforation after curettage. Methods: Case report. Conclusion: Uterine perforation and ileum prolapse in this patient was a complication from unsafe abortion from unregistered health practicioner, fortunately the outcome is good, although actually it could be prevent. [Indones J Obstet Gynecol 2012; 36-3:150-3] Keywords: hysteroraphy, ileum anastomose, ileum laceration, ileum prolapse, ileum resection, incomplete abortion, uterine perforation

Fertility Outcomes after Laparoscopic Reversal of Tubal Sterilization Hadisaputra, Wachyu
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know pregnancy outcome in the tubal reversal of sterilized women. Method: Literature review. Results: Sterilization is considered the most common contraception methods in United States of America, approximately 39% women in reproductive age (15 - 44 years) used this method. However, approximately 15% of these patients deplored this decision due to the influence of their own environment and some factors, such as: young age, the death of a child, the disability of child, and change of partner/ remarried. Tubal reanastomosis or tubal reversal is a surgical procedure that attempts to restore the fallopian tube patency following sterilization. To date, the modern procedure is performed by doing an excision of the tubal segment and reanastomosis by transabdominal laparoscopy. Recently, the laparoscopic technology has developed and evolved rapidly as the robotic assisted laparoscopy was invented. There is alternative method for restoring the fertility in sterilized women who regretted the decision of being sterilized. Unlike the tubal reversal which is conducted in order to restore the tubal function, the IVF is performed to bypass the function of tubes in fertility. The major advantage for laparoscopic surgery is short postoperative stay duration with minimal tissue handling, less postoperative adhesions, and diminish morbidity rate. Despite of its major drawback, high-cost of robotic machine and machine maintenance; there are advantages of robotic laparoscopy compared to the conventional laparoscopy, such as improved dexterity, more precise and accurate articulation, reduced tremor, and better visualization of the operating field. In vitro fertilization (IVF) is the hallmark in the era of assisted reproductive technology and became an alternative option to regain the fertility in sterilized women. Conclusion: The pregnancy rate and live birth rate in laparoscopy, robotic and open surgery were relatively similar. Surgical reversal to women younger than 40 is recommended and laparoscopic reversal should be performed if the expertise is available. It is reasonable to counsel IVF to over 40 women. [Indones J Obstet Gynecol 2012; 36-3: 154-60] Keywords: gynecology, IVF, pregnancy outcomes, reanastomosis, robotic laparoscopy, tubal reversal

One Point Technique of Intracutaneous Sterile Water Injection is as Effective as Four Points Technique in the Management of Labor Pain Ismail, Taufik
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the score of VAS (visual analog scale), length of labor, and APGAR score in intracutaneous sterile water injection between one point technique and four points technique at Michaelis Rhomboid area in management of labor pain. Method: This is an experimental study, subjects were included by blinded controlled randomized study on 50 women with term pregnancy stage I active phase and were planned for spontaneous delivery. Subjects were divided into 2 groups randomly, 25 women with 0.5 ml sterile water intracutaneous injection on 4 points and 25 women with that on 1 point injection at one site at the painful area. Result: Reduction of labor pain on 1-point technique could decrease VAS score the most, 85.4 (4.3) into 48.4 (8.5) on minute 10. Length of labor was 11.2 (1.15) on 1 point injection group compared to 11.4 (1.2) on those with 4 point injection. On the other hand, APGAR score of the baby on group having 1-point injection was 7.86 (0.5) on min 1 and 9.68 (0.5) on min 5, compared to that on 4-points injection group, 7.52 (0.7) and 9.56 (0.5), respectively. In addition, 60% felt uncomfortable with 1-point injection whereas 80% of patients felt uncomfortable in 4-points injection. Conclusion: There is no significant difference on reduction of VAS score, duration of labor, and APGAR score of the baby between the group having 1 point injection and 4-point injection. However, injection on 1 point is more comfortable. [Indones J Obstet Gynecol 2012; 36-4: 167-70] Keywords: APGAR , intracutaneous sterile water injection, length of labor, VAS

The Serum Level of Vascular Endothelial Growth Factor (VEGF) is Declined after Paclitaxel-Carboplatin Combined Chemotherapy Treatment on Epithelial Ovarian Cancer Abdullah, Amelia
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To assess the effect of Paclitaxel-Carboplatin combination on epithelial ovarian cancer by studying the changes in VEGF serum levels after receiving 3 series of chemotherapy. Methods: This was a cohort study conducted at several teaching hospitals in Obstetrics and Gynecology Department of the Faculty of Medicine, Hasanuddin University from April 2011 to March 2012. The subjects were patients with ovarian cancer who met the inclusion criteria and had undergone surgery. The clinical staging was determined with 2009 FIGO criteria. They went through histopathology examination to determine the histological type and cell differentiation of the lesion. They also went through combined chemotherapy of Paclitaxel and Carboplatin. The data were analyzed with paired t-test. Results: The study reveals that out of 30 cases of ovarian cancer who received a combination chemotherapy, most were < 45 years of age (53.33%), nulliparous (46.7%), serosum type (53.3%), with moderate differentiation (36.7%), and in advanced stage (73.3%). The VEGF serum level after 3 series of chemotherapy was lower than before (the average value: 294.67 vs 572.77 ng/ml). There was a significant change in VEGF serum level after receiving chemotherapy (p=0.000). The VEGF serum level of advanced-stage and early stage epithelial ovarian cancer after chemotherapy decreases significantly (p=0.000 and p=0.011). The advanced-stage cases showed more responses to chemotherapy than the early-stage did. There was a tendency that adenocarcinoma serosum type was more responsive to the therapy than mucinosum type (p=0.000 vs 0.003). Conclusion: There is no difference in VEGF serum level based on cell differentiation but there is a tendency that well and moderate differentiated cells have a greater change than the poor differentiated cells (p=0.003, p=0.003 vs p=0.019). [Indones J Obstet Gynecol 2012; 36-3: 135-9] Keywords: carboplatin, epithelial ovarian cancer, paclitaxel, VEGF

High Level of Tumor Necrosis Factor (TNF)-Î± is a Risk Factor for Preeclampsia I.G.N. Anom
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To define that elevated TNF-Î± serum level was the risk factor of preeclampsia in pregnancy. Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-Î± was obtained at Prodiaâ€™s clinical Laboratory Denpasar. Dataâ€™s normality test was done with Kolmogorov-Smirnov, then an analysis of data was done with Independent Sample Test, predictive value a = 0.05. To define the role of TNF-Î± level in preeclampsia, Chi-Square test was chosen. Result: From this research we found the average level of TNF-Î± in preeclampsia (6.64 Â± 7.64 pg/ml) was higher than in normal pregnancy (2.42 Â± 1.77 pg/ml). Analysis with t-independent test shows that the t-value was 2.85 and p-value was 0.006, which means that the average level of TNF-Î± between the two group was significantly different (with predictive value, p<0.05). Based on cut-off value 2.42 pg/ml, the relative risk for preeclampsia was six time (RO = 6.33, IK 95%=1.97-20.34, p = 0.001) in patient with TNF-Î± level greater than 2.42 pg/ml. Conclusion: TNF-Î± level in preeclampsia was significantly different with TNF-Î± level in normal pregnancy and the elevated serum level of TNF-Î± in pregnancy could be one of the risk for preeclampsia. [Indones J Obstet Gynecol 2012; 36-3: 107-11] Keywords: normal pregnancy, preeclampsia, TNF-Î±

Lower Glutathione Peroxidase Serum Level Compared to Normal Pregnancy Kadek Pramarta
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of glutathione peroxidase (GPx) in threatened miscarriages and normal pregnancy. Method: This is an analytic cross sectional study with 42 samples divided into two groups. Group 1 consists of 21 cases of threatened miscarriages with < 20 gestational age and group 2 is divided into 21 normal pregnancies of < 20 weeks gestational age. We took 3 cc of blood samples from the cubiti veins and mixed it with EDTA. Its GPx quantities were than examined at the Pathology Lab at Sanglah General Hospital. Data was then analyzed using the Shapiro Wilk Test and the independent t-test with p < 0.05. Result: From this research, we obtained the mean GPx levels on the threatened miscarriages was 49.92 Â± 14.17 U/g Hb lower than the mean of normal pregnancy levels, which was 88.94 Â± 30.11 U/g Hb. Conclusion: The quantities of GPx between threatened miscarriages and normal pregnancies are statistically different, in which the quantity of GPx in threatened miscarriages is lower compared to normal pregnancy. [Indones J Obstet Gynecol 2012; 36-3: 112-5] Keywords: GPx, normal pregnancy, threatened miscarriages

High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design, performed at several hospitals of Department of Obstetrics and Gynecology Medical Faculty of University of Hasanuddin, Makassar. Subjects met to inclusion criteria were taken as samples. Placental tissue samples were taken from cord insertion site and fixated with formalin buffer solution. Immunohistochemical examination was performed at Center of Research University of Hasanuddin. Antibody used were primary antibody of Mouse monoclonal anti VEGFR-1 antibody (Santa Cruz) dissolved to 1:100 and link antibody (secondary antibody labeled with biotin) (Dakopatt). Placental tissues were examined in Streptavidin biotin peroxides and interpreted according to the intensity of trophoblast cytoplasmic dye. Results: High VEGFR-1 expression was found in 100% of the placenta from patients with eclampsia , 42.9&% in patients with HELLP syndrome and 37.8% in patients with severe preeclampsia. High VEGFR-1 expression was correlated to incidence of eclampsia (p=.000) and not correlated to severe preeclampsia and HELLP syndrome (p=0.734). Conclusion: High VEGFR-1 expression was correlated to eclampsia and not correlate to severe preeclampsia and HELLP syndrome. [Indones J Obstet Gynecol 2012; 36-3:116-20] Keywords: eclampsia, HELLP syndrome, severe preeclampsia, VEGFR-1 expression

Moderate-Severe Endometriosis Shows Higher CA-125 Serum Level Compared to Minimal-Mild Endometriosis Jhonny Yudho
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate and compare serum profile of CA-125, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in various stages of endometriosis. Methods: Forty endometriosis patientsâ€™ blood samples were taken prior to laparoscopic surgery for various indications. Diagnosis of endometriosis was confirmed by laparoscopy. Independent T test methods were used for statistical analysis. ROC analysis was examined for each variable. Results: The mean level of CA-125 serum was 12.0 vs. 36.3 U/ml (p < 0.05); ESR serum was 11 vs. 12.8 mm/hour (p > 0.05); CRP serum was 0.7 vs. 0.3 (p > 0.05) for endometriosis stage I-II and stage III-IV, respectively. The optimal cut off point to discriminate endometriosis stage I-II and III-IV was 16.9 U/ml with sensitivity 83% and specificity 81%. Conclusion: The CA-125 serum level was increased for moderatesevere compare to minimal mild endometriosis patient. [Indones J Obstet Gynecol 2012; 36-3: 121-4] Keyword: CA-125, CRP, endometriosis, ESR, serum

The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level Mariza Yustina
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the Neuropeptide Y (NPY) levels in nonobese Polycystic Ovary Syndrome (PCOS) patients without insulin resistance and non-obese women without insulin resistance, in consideration of the psychopathologic conditions occurring in PCOS patients as well as the influence of these changes in affecting NPY levels. Methods: The subject was fourteen PCOS patients and 20 non-obese normal women, both without insulin resistance. The measurements of blood NPY levels using the ELISA method and a psychology assessment using Symptom Check List 90 (SCL-90) were carried out. Statistical analysis was performed using SPSS 17. Results: From 20 PCOS patients included in this study, 6 subjects (30%) were detected as having psychopathologic problems through completion of the SCL-90 questionnaire, with a cut-off score of >70 points. Measurement of NPY levels using ELISA found a mean NPY level of 8.02 Â± 3.92 (95% CI 2.39 - 18.66) in the PCOS group compared to a mean of 7.78 Â± 4.31 pg/ml (95% CI 0.74 - 15.47) in the control group. No significant difference was found in the mean levels of NPY between the two groups. Statistical assessment using the Spearman 2-variable correlation test also found no significant correlation between NPY levels and the SCL-90, scores in the PCOS group. Conclusion: There was no significant difference in NPY levels between the PCOS group and control group. Thirty percent of non-obese PCOS patients without insulin resistance were identified as having psychopathologic conditions. But in this group of patients, the psychopathologic changes had no influence on the levels of blood NPY. [Indones J Obstet Gynecol 2012; 36-3: 125-9] Keywords: neuropeptide Y, PCOS, psychopathologic conditions

Letrozole 2.5 mg Shows Higher Endometrial Thickness Compared to 5 mg Letrozole in Ovulation Induction Anita Tobing
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the effects of ovulation induction with 2.5 mg letrozole to 5 mg letrozole by the number of mature follicles, endometrial morphology and endometrium thickness during the late follicular phase in infertility patient who successfully became pregnant. Method: This was a cross sectional study. We collected the data of infertility patient who successfully became pregnant after receiving ovulation induction regiment of 2.5 mg and 5 mg letrozole. Result: There mean number of follicles with diameter â‰¥ 18 mm was higher in group receiving 5 mg letrozole (1.64 SD Â± 0.91) compared to group receiving 2.5 mg letrozole (1.37 SD Â± 0.56) but statistically, there was no significant difference (p = 0.134). Endometrial thickness, which was measured by transvaginal ultrasound on the twelfth day of menstrual cycle, showed a significant difference (p = 0.023) between the groups. The endometrium was thicker in patients receiving 2.5 mg letrozole (7.83 mm SD Â± 0.87) compared to patients receiving 5 mg letrozole (7.6 mm SD Â± 1.10). The most common endometrium morphology found was triple line endometrium, both in group receiving 2.5 mg letrozole (65%) and in group receiving 5 mg letrozole (50%). Conclusion: There was a significant difference in endometrial thickness between the pregnant patients who had received 5 mg of letrozole and 2.5 mg of letrozole for ovulation induction and the most common endometrium morphology and description was triple line endometrium in both research groups. But there was no significant difference between the number of â‰¥ 18 mm follicles on 2.5 mg doses and 5 mg doses of letrozole. [Indones J Obstet Gynecol 2012; 36-3: 130-4] Keywords: endometrium morphology, endometrium thickness, infertility, letrozole, ovarium follicles

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
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Journal Mail Official
support@inajog.com

Editorial Address
-

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA