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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 29 Documents

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Search results for , issue "Volume. 36, No. 4, October 2012" : 29 Documents clear

Lamellar Body Count has Higher Sensitivity and Specificity in the Prediction of Neonatal Respiratory Distress Syndrome Aryando Pradana
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: The study was designed to acquire the cut-off value for lamellar body count and its role in predicting the presence of Respiratory Distress Syndrome (RDS) in pregnancy with gestational age above 28 weeks. Method: Amniotic fluid specimens were collected by amniotomy during cesarean section from women with gestational age above 28 weeks. A haematology analyzer (Advia 120) was used to determine the lamellar body counts. We also performed foam stability test and observed the development of respiratory distress syndrome. Receiver operating characteristics curve was estimated to assess the threshold of lamellar bodies count that may predict the presence of Respiratory Distress Syndrome. Result: Fifty nine specimens were collected from woman with 29 - 42 weeks gestational age. The incidence of Respiratory Distress Syndrome was 15.3%. Area under the curve for lamellar body count was 0.94. Lamellar body count, with the best cut-off point of 50,000 cell/Î¼l had sensitivity 89% and specifity 92% for predicting the presence of RDS, while the sensitivity of foam stability test was 67% and specificity was 90%. The negative predictive value of the lamellar body count was 98% slightly better than the negative predictive value of the foam stability test 94 %. Conclusion: Although both test are good predictor of RDS, lamellar body count has higher sensitivity and specificity. It also has more advantages as it only requires small amount of sample, fast, easy and more objective. [Indones J Obstet Gynecol 2012; 36-4: 176-80] Keywords: foam stability test, lamellar body, respiratory distress syndrome

Placental Growth Factor Level is Lower in Early-Onset Preeclampsia, while Tumor Necrosis Factor Alpha Level does not Show any Difference between Early and Late Onset Preeclampsia Christofani Ekapatria
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze the difference of PlGF and TNF-Î± serum level between early-onset and late-onset preeclampsia. Method: This is a cross-sectional analytic comparative study comparing serum level of PlGF and TNF-Î± between groups with earlyand late-onset preeclampsia. Each group consists of 32 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital or its district hospitals in September - November 2012. Statistical analysis was performed with Kolmogorov Smirnov test, Saphiro-Wilk test, and non-parametric Mann-Whitney test. Result: Mean of PlGF serum level in the group with early-onset preeclampsia is 53.0344Â±38.07140 pg/ml, while mean of which in the group with late-onset preeclampsia is 241.8063Â±192.8373 pg/ml (p<0.0001). Mean of TNF-Î± serum level in the group with early-onset preeclampsia is 2.7733Â±0.97533pg/ml, while mean of which in the group with late-onset preeclampsia is 2.5061Â±0.84872 pg/ml (p= 0.235). Conclusion: Serum level of PlGF in early-onset preeclampsia is lower than the level of which in late-onset preeclampsia (p<0.0001). There is no significant difference of TNF-Î± serum level between the early- and late-onset preeclampsia (p=0.235). [Indones J Obstet Gynecol 2012; 36-4: 181-4] Keywords: early onset, late onset preeclampsia, PlGF, preeclampsia, TNF-Î±

Progesterone Serum Level in-Labor Women does not Differ with not in-Labor Women Caroline Hutomo
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To find out the relation of serum progesterone level between patients in-labor and pregnant patients not in-labor. Methods: This was an analytic cross-sectional study, comparing serum progesterone level between in-labor gravida and not in-labor gravida. Subjects were in-labor gravida (n=21) and not in-labor gravida (n=24) admitted to Sanglah Hospital from April to August 2011. The data were analyzed by SPSS 16.0. Independent sample ttest and Fisherâ€™s exact test were used. Results: Mean serum progesterone level were 214.90Â±92.06 inlabor gravida and 190.69Â±76.02 not in-labor gravida (t = 0.966 and p = 0.399). Conclusions: There is no difference in serum progesterone level between in-labor and not in-labor pregnant women. [Indones J Obstet Gynecol 2012; 36-4: 185-7] Keywords: labor, progesterone, progesterone withdrawal

Elastin Expression in Sacrouterina Ligament is Weaker in the Women with Pelvic Organ Prolapse Andi Hasnawati
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: The research aims at comparing the elastin immunolabeling in the uterosacral ligaments in women with pelvic organ prolapse and without pelvic organ prolapse (POP). Methods: The research is done at Dr. Wahidin Sudirohusodo Hospital and education networking some hospitals the Obstetrics and Gynecological School of Medicine Hasanuddin University that began in January 2011 until April 2012. This research assessing expression of elastin on 35 women with a pop level III and IV and as control is 35 women without POP. Immunolabeling of elastin valued in staining checkings immunohistokimia uses antibodies elastin ( clone no. Ba-4 1:1600; Novacastra Laboratories Ltd, UK). The research was carried out by the cross sectional study. Mixed with chi-square. Level significance used is 0.05. Results: The results showed that the elastin immunolabeling in women with POP is decline on most sample expression with the intensity of elastin is weak (74.3%). The most control with the intensity of elastin immunolabeling is moderate (48.6%). Elastin immunolabeling seem significant in women with menopause and with BMI that overweight (all with p<0.05). Other factors that contributed to the occurrence of pelvic organ prolapse are age, parity, history of childbirth, and the history of newbornâ€™s weight. Conclusion: Elastin expression is weaker in the sacrouterina ligament of women with pelvic organ prolapse, thus it could contribute to the occurence of pelvic organ prolapse. [Indones J OIbstet Gynecol 2012; 36-4: 188-93] Keywords: elastin, pelvic organ prolapse, risk factor

Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis Yahya Irwanto
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test and the correlation Spearman test. Result: Ninety one patients underwent radical hysterectomy for two years and 43 patients were included in these study. The expression of Fas Ligand in 7 patients (16.3%) were negative and the others were positive, with weak, moderate and strong expression were 4 (9.3%), 27 (62.8%), and 5 (11.6%) respectively. The expression of Fas Ligand was significantly higher in the group of patients with positive pelvic lymph node compared to the group of the patients with negative pelvic lymph node (p=0.007) but there was no significant difference between group of the patients with LVSI positive and negative. With Spearman test, we found that the expression of Fas Ligand had a strong correlation with pelvic lymph nodes metastasis (coeff. correlation=0.519 and p=0.00) and have no correlation with LVSI (coef. corellation=0.112 and p=0.474). Conclusion: These finding suggested that expression of Fas Ligand in cervical cancer patients has a strong correlation with the incidence of pelvic lymph node metastasis and none with LVSI. [Indones J Obstet Gynecol 2012; 36-4: 194-9] Keywords: cervical cancer, fas ligand, immunohystochemistry, LVSI, pelvic lymph node metastasis

Evaluation of Combination Chemotherapy Effect of Platinum, Vincristin, Bleomycin, and Mitomycin C on Cervical Cancer Based upon Apoptosis Description Agus Hasan
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To observe the success of platinum, vincristin, bleomycin and mitomycin C (PVB-MMc) combination chemotherapy on cervical carcinoma by evaluating apoptosis feature. Methods: This study was performed at Dr. Wahidin Sudirohusodo Hospital and several other hospitals. The method of this study was prospective longitudinal. Cervical biopsy was performed on 15 cervical carcinoma patients before and after PVB-MMc chemotherapy. Six patients were at early stage and 9 patients were at advanced stage. Biopsy result were sent to pathologic anatomic laboratory to be made into paraffin block and further examined for apoptosis with Tunel method. Data were analyzed by using Wilcoxon Signed Rank test. Results: Study results indicating no significant difference for apoptosis index before and after PVB-MMc chemotherapy for early stage (p=0.463), advance stage (p=0.594), but quantitatively there were increasing apoptosis index before and after chemotherapy. Conclusion: Chemotherapy combination PVB-MMc for cervix carcinoma can increase apoptosis index and give a good response in term of reducing the tumor size although statistically not significant. [Indones J Obstet Gynecol 2012; 36-4: 200-5] Keywords: apoptosis, cervical carcinoma, PVB-MMc combination chemotherapy.

Giant Condyloma Acuminatum in a Woman with AIDS Laila Nuranna
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To describe a case of Giant Condyloma Acuminatum with aspect of HIV and some concerns about the CD4. Result: We describe 2 cases, the first case is a giant Condyloma in HIV patient and the second case is a giant Condyloma in pregnant woman. The patient in the first case was a 40-year-old woman with AIDS (CD4 is 290) who was undergoing anti-retroviral therapy. She was found to have a giant condyloma acuminatum of the vulva. Electrocautery excision was performed, and afterwards the quality of life has improved significantly. The second case patient is a 30-year-old G4P3A0 woman with a giant condyloma acuminatum. She was 30 weeks pregnant with a single fetus. On the external genitalia there was a giant condyloma mass on the vulva extending towards the peri-anal area, obstructing the introitus. The electrocautery excision was performed. She was discharged from the hospital on the second day in good condition. She had a spontaneous delivery after reaching full term. Conclusion: Although the giant Condyloma Acuminatum is combined with HIV, but itâ€™s not as difficult as imagined because the tumorâ€™s base is not wide, but shaped like inverted mushroom and it is not necessary to do local flap reconstruction. [Indones J Obstet Gynecol 2012; 36-4: 206-10] Keywords: electrocautery excision, giant condyloma acuminatum, surgery in AIDS

Hyperglycemia in Pregnancy: Recent Diagnostic Criteria and Pharmacologic Treatment for Glycemic Contro John M.F. Adam; Fabiola M.S. Adam
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v36i4.1475

Hyperglycemia in pregnancy, or formerly known as gestational diabetesmellitus, is defined as carbohydrate intolerance of variable severitywith onset or first recognition during pregnancy. The classicalscreening and diagnosis of hyperglycemia in pregnancy is the twostepsscreening, consists of 50 gram glucose load and follow by 3-hour 100 gram oral glucose test for those who were screening positive.The diagnosis of hyperglycemia in pregnancy is made if at leasttwo abnormal elevated values i.e. fasting > 95 mg/dl, 1 hour > 180mg/dl. 2 hour > 155 mg/dl, and 3 hour > 140 mg/dl.The International Association of Diabetes and Pregnancy StudyGroups Consensus Panel (IADPSG) in 2010 and the American DiabetesAssociation in 2011 change the method of screening and diagnosticcriteria. In the new method of screening all pregnant woman,not only the high risk group, should be screened using oral glucosetolerance test with 75 gram of glucose. The new diagnosis criterianeed only one abnormal plasma glucose value i.e. fasting > 92 mg/dlor 1 hour > 180 mg/dl, or 2 hour > 153 mg/dl. There is debate whichcriteria should be used universally, since the new criteria will increasethe prevalence of hyperglycemia in pregnancy.In most diabetic clinics, especially in the North America, besidesmedical nutrition therapy, insulin remains the mainstay of treatmentfor this patient. However, for those women who cannot afford insulinor do not wish to take insulin, glibenclamide and metformin, maybe offered as an alternative. Most experts will prefer to use metformin,since it does not increase body weight and also has an insulinsensitivity effect.Keywords: hyperglycemia in pregnancy, IADPSG criteria, pharmacologictreatment

Evidence Based Medicine: To Use or Not To Use It? Kartiwa H Nuryanto
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v36i4.1476

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
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Journal Mail Official
support@inajog.com

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Kota adm. jakarta pusat,

Dki jakarta

INDONESIA