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Journal of Nutraceuticals and Herbal Medicine
Published by Universitas Muhammadiyah Surakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Nutraceuticals and Herbal Medicine contains peer-reviewed article and research dedicated to advancing the scientific knowledge base of health, especially health nutrition, nutraceuticals, nutrition formula for human essential and functional food. This journal includes original research concerning the herbal medicine phytochemical, phytopharmacy, phytopharmacology, phytotheraphy.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 1, No 1 (2019): JNHM 2019" : 5 Documents clear
Effervescent Granule Formulation of Bitter Melon Extract (Momordica charantia L.) with Gelatin as A Wet Granulation Binder Wati, Setia; Saryanti, Dwi
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v2i1.8052

Abstract

Bitter melon plants (Momordica charantia L.) have a bitter taste and are used as medicinal plants as diabetes, so effervescent granule preparation is made because it can be given to people who have difficulty swallowing tablets or capsules. This study to make effervescent granules formulation of bitter melon with variations the concentration of gelatin as a binder. Gelatin will produce granules of uniform size and have stronger binding capacity between particles than starch and PVP. The method of making effervescent granules was carried out by wet granulation separately. Effervescent granules are formulated with gelatin concentrations of 3%, 6% and 9%. The granules obtained were carried out by organoleptic evaluation, flow time, tapping test, water content, pH test, dissolution time and taste response. The result of evaluation physical properties obtained brown granule shape, while the result of testing the flow time, tapping test, pH test, dissolved time obtained the results that meet the requirements and moisture content tests did not meet the requirements because the use of hygroscopic acids other than that affected by the process during granule making effervescent. The taste respons test was carried out on 20 panelists, formula III had a sour taste and was preferred. Based on these results the best formula of effervescent granules is formula III because the higher the concentration of gelatin will increase the binding capacity between particles, so that the friction force between particles becomes more complicated and the flow rate gets better, and provide a sour taste so that the bitter taste of the bitter melon can be covered.
The effect of Salam Leaves Extract (Syzygium Polyanthum Wight.) on Urine Volume in The Potassium Oxonic-Induced Hyperuricemia Mice Muhtadi, Muhtadi
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.215 KB) | DOI: 10.23917/jnhm.v2i1.7637

Abstract

This study aims to determine how Salam (Syzygium polyanthum Wight.) leaves extracts affect the urine volume of potassium oxonic-induced mice. Fifteen Swiss male mice were divided into 3 groups. Group I (normal group) were given intraperitoneal aquadest 1 mL/20g.bw, group II (negative group) and group III (Salam leaves extracts group) were given intraperitoneal 250 mg/kg.bw of potassium oxonic. After 1 hour of the treatment, group I and group II were given aquadest 0.5 mL/20g.bw orally, while group III was given Salam leaves extracts  200 mg/kg.bw orally. Mice are included in metabolic cage. The cumulative urine volume data were analyzed by Kruskal-Wallis and and Mann-Whitney test with a confidence level of 95%. In the urine volume profile test, the negative group did not experience a significant increase in urine volume when compared with the Salam leaves extracts group at hyperuricemia for 3 days (p 0.05), while the negative group had higher urine volume when compared to the normal group (p = 0.007). The results of this study indicated that Salam leaves extracts were not able to increase urine volume in hyperuricemic conditions.
The Formulation and Physical Stability Test Of Gel Fruit Strawberry Extract (Fragaria x ananassa Duch.) Rahmawati, Desi Ana; setiawan, Iwan
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v2i1.8046

Abstract

Strawberry fruit (Fragaria x ananassa Duch,) is one of the traditional plants that has various bioactive compounds including phenol compounds, vitamin C, flavanoids and ellagic acid. Strawberry fruit functions as an antioxidant and antibacterial so strawberry extract can be used as gangrene wounds in diabetes mellitus The purpose of this study was to determine the effect of the gel gelling agent formula variation on its physical properties so that it can be know which formula best meets the gel physical standard.The type of research used was experimental research. The research, includes extracting strawberry fruit using maceration method. Gel with strawberries in 4 formulas, with each formula having a different base concentration of carbobol 940. Formula 1 with a concentration of 0.5%, formula 2 concentration of 1.0%, formula 3 concentration of 1.5% and formula 4 concentration of 2.0%. The gel that has been made is then tested for physical stability which includes organoleptic test, pH test, homogeneity test, adhesion test, dispersion test, viscosity test, protection power test and gel acceptability.The results of the study showed that in the organoleptic test, pH test, dispersion test, viscosity test, adhesion test, and protection test as well as acceptability the formula had the best spread and stickness and the overall standard.
Effect of Substitution of Spinach Flour (Amaranthus Sp) to Iron (Fe) Content and Acceptability of Donuts Nabila, Fathin
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.534 KB) | DOI: 10.23917/jnhm.v2i1.6706

Abstract

Spinach is a great source of iron (Fe), which is quite high. Spinach can be made into spinach flour that can be used making donuts. Donuts in general have only macro nutrients and very few other nutrients, so substitution of spinach flour is needed to increase the nutritional content of donuts, especially on iron content. The purpose of this research is to know effect of substitution of spinach flour to iron content and acceptibility of donuts. The method this research used complete random design with four substitution treatment of spinach flour (0%, 10%, 20%, and 30%). Data analysis of iron content using one way ANOVA test with 95% significance level continued Duncan test, while acceptability using Kruskal Wallis test followed by Duncan test. The results showed that the highest iron content found in donuts with 30% spinach flour substitution with the result of 135.72 mg/kg, while the lowest on donuts with 0% spinach flour substitution with the result 43.78 mg/kg. Based on the overall percentage of acceptability the highest found in donuts with 0% spinach flour substitution, while the overall percentage of acceptability the lowest found in donuts with 30% spinach flour substitution. Based the analysis test known that there is effect of subtitution of spinach flour to iron content of donuts. There is also effect of substitution of spinach flour to acceptability color, aroma, flavor, texture, and overall donuts.
Cytotoxic Activities of Ethanol Extract, Nonpolar Semipolar, and Polar Fractions of Dioscorea esculenta L.) on MCF7 Cancer Cell Haryoto, H
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.39 KB) | DOI: 10.23917/jnhm.v2i1.7853

Abstract

One of the disease that have a high contribution to the death of women in the world is breast cancer. It leads to the research and exploration to find its cure. This study is conducted to know the anti-cancer activity onethanol extract, nonpolar, semipolar, and polar fractions of lesser yam (Dioscorea esculenta L.) herbs. It also aims to find out the content of compound on semipolar fraction Dioscorea esculenta L. herbs. The extraction was carried out using maceration technique with 96% ethanol as solvent. Then, the fractination was done using vacuum liquid chromatography method with n-hexane and acetone as mobile phase with the ratio of 9:1, 8:2, 7:3, 6:4, and 5:5. After that, the phytochemical test was undertaken using the thin layer chromatographywith n-hexane and acetone as mobile phase with proportion 7:3. Meanwhile, the cytotoxic test was conducted using MTT assay method with IC50calculation was counted using linear regression between the log concentration and the percentage of living cells. The semipolar fraction of Dioscorea esculenta L. herbs has IC50value of 632,42 µg/mL, whereas the ethanol extract, nonpolar and polar fractions have the IC50 value 1000 µg/mL. Furthermore, the compound of the semipolar fraction of Dioscorea esculenta L. herbs are saponins, terpenoids, alkaloids, and phenolics.

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