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JPSCR : Journal of Pharmaceutical Science and Clinical Research

jpscr
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Published by Universitas Sebelas Maret

ISSN : - EISSN : 2503331x DOI : -

Core Subject : Health, Social,

Environmental Science Public Health

Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.

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Articles 5 Documents

Search results for , issue "Vol 1, No 2 (2016)" : 5 Documents clear

Ethanol Extract, Ethyl Acetate Extract, Ethyl Acetate Fraction, and n-Heksan Fraction Mangosteen Peels (Garcinia mangostana L.) As Source of Bioactive Substance Free-Radical Scavengers Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Mangosteen peels (Garcinia mangostana L.) is well known as an excellent source of antioxidative compounds. The name of mangosteen is xanthone. Antioxidant of mangosteen peels can be extracted by ethanol, etyl acetate and can be fractinated by etyl acetate and n-hexane. The aim of this research was to compare the antioxidant activity of the peel extract by ethanol and etyl acetate and fractinated by etyl acetate and n-hexane. Extract and fraction exhibited higher scavenging activity of DPPH. The purpose of this study was to compare antioxidant activity of ethanol extract, ethyl acetate extract, fraction of ethyl acetate and n-hexane fraction. The antioxidant activity test using DPPH method with UV-Vis spectrophotometer. Ethanol extract shown IC50 value 5,03 µg/mL, ethyl acetate extract shown IC50 value 41,56 µg/mL. Ethyl acetate fraction shown IC50 value 2,78 µg/mL, and n-hexane fraction with IC50 22,33 µg/mL. It means peel extract and fraction by mangosteen peels has very strong antioxidant activity and ethyl acetate fraction that its antioxidant activity higher that the other solvent.

Analgesic Activity of Ethanolic Extracts of Karika Leaves (Carica pubescens) In Vivo Heru Sasongko; Sugiyarto Sugiyarto; Nur Rohman Efendi; Diah Pratiwi; Ahmad Dwi Setyawan; Tetri Widiyani
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Karika (Carica pubescens)is a typical plant of the Dieng plateau. Previous study showed that Caricapubescenscontains chemical compound such as flavonoid that play role in analgesic activity. This study was aimed to determine the analgesic activity of etanolic extracts of karika leaves) in vivo using writhing method. The study was conducted on 25 male mice strain Swiss-Webster (20-30 g, 2-3 months) that were randomly divided into 5 groups. Group I was given distilled water 1 mL (p.o) as negative control, group II was given tramadol 50 mg/kgBW (p.o) as positive control, and group III-V received an etanolic extracts of karika leaves in 3 doses, i.e. 20 mg/kgBW, 40 mg/kgBW, and 80 mg/kgBW (p.o), respectively. Acetic acid 0,5% (v/v) was used as pain inductor. The writhe was observed within 1 hour. Data analysis was carried out by using one way ANOVA. The result showed that the ethanol extract of leaves Karika (Carica pubescens) have activity as an analgesic at a dose of 20 mg / kg, 40 mg / kg and 80 mg / KgBW (p <0.05), chemically induced, where a dose of 80 mg / KgBW (p.o) produce the most high analgesic activity.

Identification Of Potentialantibiotics – Drugs interaction On Pneumonia Prescription Yeni Farida; Anisa Dewi Soleqah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Pneumonia is lower respiratory tract infections, which is the leading cause of death in developing countries. Antibiotics are the primary therapy in cases of pneumonia due to bacteria. The use of antibiotics with other drugs allowing harmful effect. This study aimed to determine the significancy of antibiotics interaction and determine the phase of potential drug interaction could be happened.Data were collected retrospectively by taking data on the patient's medical record. Samples were obtained by purposive sampling. Inclusion criteria were patients diagnosed pneumonia with comorbid and got antibiotic therapy.The results showed that there were 12 types of drugs combinationthat could potentially cause drug interactions .Potential interactions with other drugs antibiotics based on the literature occurred in the absorption phase (12.82%), metabolism (35.9%), and excretion (51.28%).

Anti-inflammatory Effect of cream and ointment from 2,5- bis- (4-Nitrobenzilidine) cyclopentanoneagainst Edema in Mice Induced by Formalin Paulina Maya Octasari; Fransiska Ayuningtyas
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Creams and ointments are topical dosage forms used in the manufacture of drugs. Topical anti-inflammatory drug is a solution to problems of gastrointestinal side effects caused by taking nonsteroidal anti-inflammatory drug orally. The compound 2,5-bis (4-nitrobenzilidine) cyclopentanone is an analog of curcumin which has better anti-inflammatory activity than curcumin. This study aimed to determine the antiinflammatory effect of cream and ointment from 2,5-bis (4-nitrobenzilidine) cyclopentanoneagainst edema in mice induced by formalin. This research were experimental randomized complete design using a single factor. Twenty mice were divided into 4 groups: group I were given a cream base, the group II were given ointment base, group III were given cream compound 0.25% and group IV were given ointment compound 0.25%. The data were processed into AUC values and the percentage of anti-inflammatory effectwere calculated. Results were analyzed using ANOVA and T-test statistics. The results showed that between the dosage form had statistically difference of anti-inflammatory effect (p<0.05). The ointmentshowed a greater value of antiinflammatory activity rather than cream.

Cytotoxic Activity Of Non Polar Fraction From Annona Muricata L. Leaves On Hela And Raji Cell Line Anif Nur Artanti; Okid Parama Astirin; Adi Prayitno
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

The main focus of the research is cancer by a viral infection such as nasopharinx and cervical cancer that have high incidence in Indonesia. Cervical cancer is due to the viral infection known as the Human Papilloma Virus (HPV) and nasopharing cancer is a cancer that is caused by EBV infection (Eppstein Barr virus). The main priority of nasopharinx and servix cancer treatment is the use of chemotherapeutic agents, but it might also lead to diverse side-effects. The focus of this study was to develop the potency of non polar fraction from Annona muricata L. leaves by observing the cytotoxic effect on Hela and Raji cancer cell line.

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Jawa tengah

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