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JPSCR : Journal of Pharmaceutical Science and Clinical Research

jpscr
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Published by Universitas Sebelas Maret

ISSN : - EISSN : 2503331x DOI : -

Core Subject : Health, Social,

Environmental Science Public Health

Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.

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Articles 7 Documents

Search results for , issue "Vol 2, No 1 (2017)" : 7 Documents clear

Determination Sun Protecting Factor (SPF) Of Krokot Herbs Extract (Portulacaoleracea L.) Widya Astuty Lolo; Sri Sudewi; Hosea Jaya Edy
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Purslane is a plant that thrives in open areas and has a fairly high water content. Hereditary purslane plant has been used for skin protection from the sun. The aim of this study is to determine the value of Sun Protecting Factor (SPF) of ethanol extracts, soluble and insoluble fractions of ethyl acetate from purslane herb.Extraction using maceration method by ethanol 90%. Fractionation process is the partition obtained soluble and insoluble fractions of ethyl acetate. Absorbance values read using UV-VIS spectrophotometry at a wavelength of 290-320 nm. SPF value is obtained for the ethanol extract 19.495, 20.829 for the soluble fraction of ethyl acetate and 30.055 for an insoluble fraction of ethyl acetate.

Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design Dian Eka Ermawati; Saifullah Sulaiman; Indah Purwantini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Hydroalcoholic extract of turmeric (Curcuma longa L.) doses of 1.66 mg/kg containing 10% of curcuminoid was recommended as a supplement for prevention of atherosclerosis. This study aimed to formulate hydroalcoholic extract of turmeric into chewable which are more acceptable and practical. Mannitol-Lactose selected as a filler to make the chewable in this study. Optimum composition of filler of the mixture obtained by the Simplex Lattice Design method.Identification of turmeric rhizome has been done at Departemen of Plant Taxonomy, Faculty of Biology, Gadjah Mada University, Yogyakarta, Indonesia. The rhizome extraction carried out as re to research carried out by Quiles. The mixture between curcuminoid, ethanol and water extract made up to 25% level of curcuminoid level. Then, Extract was granulated with combination of filler mannitol-lactose to be five formulas, there are: FI (mannitol 100%), FII (mannitol-lactose 75%:25%), FIII (mannitol-lactose 50%:50%), FIV (mannitol-lactose 25%:75%), FV (lactose 100%). The granules then tested their physical properties such as flowability, compactibility, and water content. Furthermore, the granules tableted and physical tested including : weight uniformity, hardness, friability, absorption, flavor acceptance and soluble time. Determining the optimum formulation obtained from the physical properties of the granules and chewable physical properties based on SLD methods. Optimum formula of chewable then tested with kurkuminoid levels. The physical properties data of granules and chewable were analyzed statistically using student’s t-test.The result of this study was the optimum formula obtained from the mixture of mannitol-lactose fillers with a ratio of 90% mannitol: 10% lactose. The optimum formula of turmeric extract chewable produced meets the physical properties of the granules and chewable. Acceptance of flavor chewable optimum formula appreciation in the range of sweet and sour taste to sour. Percentage kurkuminoid levels in chewable after manufacture process was 76.42%.

The Influence of Attitude and SubjectiveNorm Towards The Purchase Intention as Potential Consumer of Mouthwash Product Fea Prihapsara; Rosyta Velayanti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Mouthwash is used by some people to maintain oral hygiene in order to avoid the interference of oral cavity diseases. Theory of Reasoned Action (TRA) is a theory measuring the influence of behavioral and subjective norm regarding someone’s perception toward the purchase intention. The objective of this research is to analyze the influence of attitude and subjective norm both partially and simultaneously towards the purchase intention of mouthwash potential consumer.This study is non-experimental descriptive research with the survey method and data collection carried out by cross sectional by using judgemental sampling technique. The population of this research is all of Surakarta society which has been using mouthwash in six month untill March 2013 as the research subject. There are 120 respondents in this research. Data analysis using multiple linier regression to determine the influenceof attitudeand subjective norm towards the purchase intention.The result of the research shows that consumers attitudepartiallyinfluences toward mouthwash purchase intention (t-value 0,000), subjective norm partially influences toward mouthwash purchase intention (t-value 0,038), and attitude and subjective norm simultaneouslyinfluence toward mouthwash purchase intention that is 36,5% (F-value 0,000).

Uniformity Test Tablets Of Atorvastatin on the Market Using Ultraviolet Spectrophotometer Sholichah Rohmani; Adi Yugatama; Ahmad Ainurofiq; Fea Prihapsara; Felicitas Lady
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Atorvastatin is one of the first choice in the treatment of dyslipidemia associated with a decreased risk of cardiovascular disease. Drug patent expires in 2011. Currently in Indonesia circulated atorvastatin dosage tablet innovator , several trade names , and one generic. The purpose of this study was conducted to determine the quality of the preparation of atorvastatin market in Indonesia through tablet dosage uniformity test , so that the appropriate levels of drugs can provide the desired therapeutic effect.Uniformity tablet dosage form of atorvastatin is done by measuring the uniformity of tablet weight, and content uniformity was done using ultraviolet spectrophotometry in methanol at the maximum wavelength of 246.2 nm and their validity was tested on the value of LOD (limit of detection), and LOQ (limit of quantitation). One- Way ANOVA analyzis was their also conducted. The results showed that of the calculation data obtained , either in column A or column B that there is no deviation from the weight of the tablet , and based on the calculation of CV showed that all the tablets of atorvastatin in the market already qualified uniformity of weight as indicated by the value of CV < 5 %, and the levels atorvastatin tablet generic and tablets under the trade name meets the standard requirements of a tablet that in the range 90.0 % - 110.0 % of the amount listed on the label

Antioxidants Effectivity In Skin Lotion Formulation Of Mesocarp Fruit Extract Lontar (Borassus Flabellifer) Against White Rats Wistar Male In-Situ Luthfiasari Amatullah; Tri Nur Cahyaningrum; Anisa Nur Fidyaningsih
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Study of bioactive mesocarp on palm fruits has been conducted previously. Therefore, this research aims to make a preparation of antioxidant skin lotion palm fruit mesocarp (Borrasus flabellifer) and to evaluate the effects of antioxidants on skin preparation lotion palm fruit (Borrasus flabellifer) by In-situ.This study was an experimental study by making a preparation of skin lotion on the stability of the corresponding and testing the antioxidant treatment with a sample of 30 rats male wistar strain. The antioxidant test was divided into 5 groups randomly: negative control (-), positive control (compound sunscreen brands parasol SPF 33), group 1 (lotio extract palm fruit mesocarp with a concentration of 0.2%), group 2 (lotio palm fruit mesocarp extract with concentration of 0.4%) and group 3 (lotio palm fruit mesocarp extract with concentration 0.8%).The results of in-situ states showed 0.8% extract of palm fruit mesocarp exhibited the least erythema score which was an average of 1.7. It was comparable to positive control which exhibited similar erythema score.

Optimization Carbopol And Glycerol As Basis Of Hand Gel Antiseptics Extract Ethanol Ceremai Leaf (Phyllantus Acidus (L.) Skeels) With Simplex Lattice Design Dwi Saryanti; Izzatun Ni'mah Zulfa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Ceremai leaf (Phyllanthus acidus (L.) Skeels) is the one of the potential plant which contain flavonoid that had antibacterial activity. Carbopol is a gelling agent that is easily dispersible in water and provide consistency to the gel, while the glycerin is a humectant that can improve the softness of the gel. Carbopol can provide viscosity / hardness in the gel it is necessary to combine with glycerin to soften the gel and the increase of the spread The aims of this research to know the optimum composition from carbopol and gliserol in antiseptic gel formulation of ceremai leaf ethanol extract by Simplex Lattice Design (SLD). The method of extraction used maseration method with ethanol 70 % solvent. extract made of gel with components carbopol 940(0-100%) and glycerin(0-100%) with respond criteria physical properties such as pH, spreadability, sticking and protection power. The optimum formulated based on Simplex Lattice Design was the combination of carbopol 50 % : glycerol 50 %. Optimum results are obtained gel has a good physical properties. The test results showed that the effectiveness of antiseptic hand gels have generated a good antiseptic. Acceptability test results showed that the gel can be accepted by society.

Study of Antibiotic Use on Pneumonia Patient in Surakarta Referral Hospital Yeni Farida; Ayu Trisna; Deasy Nur
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Pneumonia is lung inflammation, mostly caused by bacteria. Antibiotics are the primary therapy in cases of pneumonia due to bacteria. This study aimed to determine the profiles of pneumonia patients and their use of antibioticsin Surakarta referral hospital.Data were collected retrospectively by using patient's medical recordand prescription on 2014-2015. Subject were obtained by purposive sampling. Patients diagnosed pneumonia with antibiotik therapywere included while patient with comorbide other infection were excluded. The result showed that the most pneumonia patient were aged 0-5 years old (27,71%, female and the average length of stay 11 days) The most single use antibiotik in pediatric patients and adults was ceftriaxone (21.09% and 66.12% respectively) . The combination of antibiotics that were widely used in pediatric patients were ampicillin-gentamicin (39.27%), while in adult patients were ceftriaxone and azithromycin (26.97%).

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