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JPSCR : Journal of Pharmaceutical Science and Clinical Research
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 2503331x     DOI : -
Core Subject : Health, Social,
Environmental Science Public Health
Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol 9, No 2 (2024)" : 12 Documents clear
Formulasi dan Uji Antibakteri Formula Optimum Gel Kitosan Kulit Udang Vannamei (Litopenaeus vannaemei) sebagai Antiakne Naniek Widyaningrum; Fita Nadia Septiana; Rina Wijayanti; Thendi Abdul Arief
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.78870

Abstract

Acne vulgaris atau jerawat merupakan infeksi pori-pori kulit yang tersumbat dengan lemak yang berlebih. Faktor lainnya disebabkan oleh aktivitas mikroorganisme Propionibacterium acnes. Kitosan kulit udang vannamei diketahui berfungsi sebagai antibakteri. Kitosan kulit udang vannamei dapat diformulasikan dalam bentuk sediaan gel untuk mendapatkan kenyamaan dan kemudahan dalam penggunaan. Tujuan penelitian ini untuk mengetahui formula optimum sediaan gel kitosan kulit udang vannamei sebagai antiakne. Optimasi formula menggunakan Simplex Latice Design dengan variasi konsentrasi gelling agent berupa karbopol dan HPMC. Uji evaluasi fisik sediaan gel dan uji antibateri terhadap Propionibacterium acnes dilakukan. Hasil penelitian formula optimal karbopol dan HPMC diperoleh perbandingan 0.5 : 0.5 dengan persentase (1,25%)  dan HPMC (0,725%). Uji evaluasi fisik sediaan gel menunjukkan bahwa sediaan gel memiliki sifat fisik yang baik dengan viskositas 4.616 cps, pH 7.25, dan daya sebar 6.43. Hasil uji antibakteri Propionibacterium acnes didapatkan hasil daya hambat dari sampel gel kitosan (20.73 mm ± 1.33) kuat dan kontrol positif (28.56 mm ± 0.91) sangat kuat. Formula optimum dengan perbandingan karbopol dan HPMC (0.5:0.5) gel kitosan kulit udang vannamei memiliki aktivitas antibakteri terhadap Propionibacterium acne dan memenuhi persyaratan uji sifat fisik.  
Tamanu Oil (Calophyllum inophyllum L.) Promotes Wound-Healing Activity in Alloxan-Induced Diabetic Rats, and Its Fatty Acids Profile Rita Rakhmawati; Saptono Hadi; Ahmad Ainurofiq; Estu Retnaningtyas Nugraheni; Syaiful Choiri; Tiara Dewi Salindri Pratama
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.80107

Abstract

Diabetes Mellitus (DM) is a metabolic disease and is a severe threat because it causes diabetic wounds. Treating injuries in patients with DM is dominated by synthetic chemicals such as anti-inflammatory, corticosteroids, and antibacterial. It has side effects, so further exploration of natural ingredients is needed. One plant that has the potential to heal wounds is tamanu oil or nyamplung oil. This study aimed to investigate the effect of tamanu oil on the healing of diabetic wounds and the fatty acid composition profile. Male rats of the Wistar strain (Ratus novergius) were given incision wounds along a 2 cm depth of 2 mm, randomly divided into three groups, by applying topically twice a day. We are profiling fatty acids using gas chromatography-mass spectrometry (GC-MS). As far as we know, this is the first study showing that tamanu oil can speed up the healing of diabetic wounds in rats. The Tamanu oil containing oleic acid (42.65%), linoleic acid (25.69%), stearic acid (16.50%), and palmitic acid (12,93) had better effectiveness than other groups, demonstrated by wound closure exceeding 50% on day six and wound closure by 100% on day nine.

Page 2 of 2 | Total Record : 12

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