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Jambura Journal of Chemistry
Published by Universitas Negeri Gorontalo
ISSN : 26563665     EISSN : 26566834     DOI : 10.34312/jambchem
Core Subject : Science,
Chemistry
Jambura Journal of Chemistry is peer-reviewed and open access journal published by Chemistry Depertment, Faculty Mathematic and Natural Science. Jam.J.Chem that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. Jambura Journal of Chemistry publish two issues (numbers) annually (February and August).
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Articles 3 Documents
 1 
Search results for , issue "Vol 5, No 2 (2023): August" : 3 Documents clear
Evaluation of Nitrogen, Phosphorus, and Potassium Levels in Rice Straw Compost for Sweet Corn Growth in Gorontalo La Kilo, Akram; Djafar, Yuliyanti Wahab; Iyabu, Hendri
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.14720

Abstract

This study aims to determine the NPK nutrient content of a mixture of soil and straw compost. -The determination of nitrogen, phosphorus, and potassium levels was carried out using the Kjeldahl method, UV-Vis, and AAS instrument, respectively.The results of the analysis showed that the levels of NPK in the mixture of soil and straw compost, the levels of N 1.6-3.6%, P 0.39-44%, and Potassium 0.14-0.16%, the results obtained that levels of nitrogen, phosphorus met the minimum standard of SNI 19-7030-2004, the potassium content is only slightly or does not meet the standard of SNI/19/7030/2004. The results of the analysis of variance (ANOVA) showed that a mixture of soil and straw compost was suitable as a planting medium for sweet corn which had a significant effect on plant height, stem diameter, stem circumference, and number of leaves.
Studi Molecular Docking dan Prediksi ADME Senyawa Metabolit Sekunder Tumbuhan Obat Tradisional Gorontalo Terhadap Reseptor HER-2 Sebagai Antikanker Payudara Ischak, Netty Ino; Musa, Weny J.A; Aman, La Ode; Alio, La; Kilo, Akram La; Saleh, Sri Deltalia
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20544

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas dan interaksi senyawa uji dari 12 tumbuhan obat tradisional Gorontalo dengan reseptor HER-2 yang merupakan protein yang terkait dengan sel kanker payudara secara in silico melalui molecular docking. Molekul dengan hasil docking terbaik akan diprediksi menggunakan program Absobsi, Distribusi, Metabolisme, dan Eliminasi (ADME) menggunakan program SwissADME secara online. Hasil validasi situs ikatan dengan menerapkan protokol penambatan ulang (redocking) menunjukkan nilai Root Mean Square Deviation konformasi ligan standar (2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5yl]ethoxy}ethanol) menggunakan Autodock Tools dengan nilai energi bebas ikatan yang terbentuk sebesar -6,32 kkal/mol. Sedangkan nilai Root Mean Square Deviation ligan standar menggunakan Autodock Vina memiliki energi bebas ikatan sebesar -11,3 kkal/mol. Hasil energi bebas ikatan ligan uji Palmarumycin CP1 sebesar -9,2 kkal/mol. Interaksi residu aktif HER-2 pada Palmarumycin CP1 dengan kontribusi terbesar terdapat pada residu Tyr 735. Hasil prediksi ADME menunjukkan bahwa hanya ada lima senyawa yang termasuk aturan Lipinski Rule of Five yaitu senyawa Tembetarine, Palmarumycin CP1, Curcumin, Cepharadione A, dan Hexahydrocurcumin. Oleh karena itu, hasil ADME menunjukkan bahwa hanya ada satu senyawa yang memenuhi aturan Lipinski Rule of Five dan sesuai dengan hasil Molecular Docking yang memiliki energi bebas ikatan sebesar -9,2 kkal/mol adalah senyawa Palmarumycin CP1.
Antioxidant Activity and Inhibition of Α-Glucosidase from Yellow Root Extract (Fatuoa Pilosa Gaudich) In Vitro Tukan, Maria Magdalena Nona Motu; Falah, Samsul; Andrianto, Dimas; Najmah, Najmah
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20503

Abstract

Yellow root (Fatoua pilosa Gaudich) is a type of plant which is found on lowland mostly in Japan, China and usually grow in the dry bushes. Traditionally, the yellow root (Fatuoa pilosa Gaudich) is used to treat the disease of diabetes mellitus and as antiinflamation. One of the causes of diabetes disease is oxidative stress. Oxidative stress can be reduced by using antioxidants. This research aims to explore antioxidant activity and inhibition of α-glucosidase enzyme from yellow root extract (Fatoua pilosa Gaudich.). Quantitative determination of total phenolic by using folin-ciocalteu method declared as gallic acid equivalents (GAE) per gram of extract, levels of total flavonoids with AlCl3 method declared as Quercetin equivalen (QE), and antioxidant activity in fertilization with the DPPH (2, 2-diphenyl-1- picrylhydrazyl) stated in the IC50 (concentration inhibition). The Results showed that the highest levels of total flavonoids was in extract ethanol 96% 199.44 g QE/g extract, while the total phenolic levels highest in 70% ethanol extracts 211.54 mg GAE/g extract. The highest IC50 obtained from antioxidant test of yellow root extrat was 70% ethanol extract 14.62 μg/mL and the most active fraction that can inhibit α-glucosidase enzyme was of ethyl acetate fraction with IC50 values 680.54 μg/mL.

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