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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol 42, No 3 (2022)" : 12 Documents clear
The Effect of N-Acetylcysteine as Adjuvant Therapy of Hypoxemia in COVID-19 Patients, Assessed by Interleukin-6 Level and PaO2/FiO2 Ratio Simon Petrus Hardiyanto Rumaratu; Ngakan Putu Parsama Putra; Yani Jane Sugiri; Susanthy Djajalaksana; Aditya Sri Listyoko; Harun al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.227

Abstract

Background: Interleukin 6 (IL-6) is a cytokine that plays an essential role in lung damage and mortality. Arterial-to-inspired oxygen (PaO2/FiO2) ratio, also known as the Horowitz index, is a measure of hypoxemia in respiratory failure. N-Acetylcysteine (NAC) might be helpful in managing coronavirus disease 2019 (COVID-19) patients by decreasing the cytokine storm, which will lead to a decrease in disease severity. This study aims to analyze the effect of NAC as adjuvant therapy on IL-6 level and PaO2/FiO2 ratio in COVID-19 patients.Methods: This is a quasi-experimental, non-equivalent control group designed study of confirmed COVID-19 patients moderate to critical in Saiful Anwar Hospital Malang. Seventy-five patients received NAC intravenously 5000mg/72 hours as adjuvant therapy for seven days, and 16 subjects in the control group. IL-6 level and PaO2/FiO2 ratio were measured on day one and day 8 in both groups from blood samples. Wilcoxon, Mann-Whitney U Test, and Pearson correlation were conducted for statistical analysis.Results: The decrease in IL-6 level on days 1 to 8 in the NAC group is significantly lower (94.49±253.51) than in the control group (P=0.002). The increase in PaO2/FiO2 ratio from day 1 to day 8 in the NAC group is significantly improving (126.94±76.05), the same as the control group (P<0.001). There is a weak correlation between IL-6 level and PaO2/FiO2 ratio after administration of NAC (r=0.154, P=0.186).Conclusion: There is a significant decrease in IL-6 level after administration of NAC. NAC has no significant effect on hypoxemia in COVID-19 patients.
Association Between Feritine Levels and Severity of COVID19 In RSUP Dr. M. Djamil Padang Elsa Purnama Sari; Irvan Medison; Russilawati Russilawati
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.244

Abstract

Background: Ferritin is one of the inflammatory markers used as a predictor for severity of COVID-19. Early assessment of severity is expected to be a priority in disease management. This study aims to determine the association between ferritin levels and the severity of confirmed COVID-19 patients at RSUP dr. M. Djamil Padang. Methods: This study is a retrospective cohort study on confirmed COVID-19 patients from January to May 2021. Chi-square analysis was calculated to assess the association between ferritin levels and clinical grade, the severity of the chest X-ray and the level of need for oxygen therapy. To assess the risk opportunities for ferritin levels based on each dependent variable, an association analysis was performed by calculating the Odds Ratio..Results: Characteristics of the patients were mostly female (54.25%), aged more than 50 years (59,00%), clinical grade above category 4 (54,75%), required oxygen therapy (74,75%), the severity of chest X-ray was mild (75.50%), ferritin level < 500 ng/ml (52.75%) and had no comorbidities (51.25%). This study found that ferritin levels correlated with clinical grade, severity of chest X-ray, and level of need for oxygen therapy with HFNC and ventilator (p<0.001). Ferritin levels > 1000 ng/mL have a risk opportunity for clinical grade category 7 OR 8.28 (95% CI 2.69-25.41), severe chest X-ray severity OR 5.52 (95% CI 2.55- 11.97) and need for oxygen therapy with HFNC and ventilator, OR 4.76 (2.70-8.39) vs OR 7.69 (3.97-14.92)Conclusion: High ferritin levels significantly increase the risk of a severe clinical severity, severe chest X-ray and the level of need for oxygen therapy using HFNC and a ventilator in COVID-19 patients.Keywords: COVID-19, ferritin levels, severity

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