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Published by Ikatan Apoteker Indonesia

ISSN : 14121107 EISSN : 2355696X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.

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Articles 18 Documents

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Search results for , issue "Vol 7, No 1 (2014)" : 18 Documents clear

Evaluasi Asuhan Kefarmasian terhadap Hasil Terapi dan Kualitas Hidup Pasien Hipertensi Primer di Rumah Sakit Harahap, Urip; Nasution, Salli Roseffi; Sitepu, Nadroh Br
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The management of hypertension ideally requires collaboration between health professionals which includes in the three aspects: medical care, pharmaceutical care, and nursing care. The purpose of this study was to determine the impact of pharmacist counseling conducted on therapeutic outcomes in systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), blood glucose levels (BGL) period, total cholesterol, and quality of life of patients were measured Short-Form Health Survey 36 (SF-36). This study was conducted at RSUD dr.R.M. Djoelham Binjai involved 60 primary hypertensive patients. Patients were divided into two groups: group counseling and with out conseling. Data were analyzed by independent sample t-test. The result of this study showed significant differences in SBP (p=0.048), BMI(p=0.014), BGL(p=0.002) and total cholesterol (p=0.000) and value of quality of life who received counseling (63.17%) and without counseling (54.80%) with p=0.001. But obtained no significant differences between DBP (p=0.068).Keywords : primary hypertension, pharmaceutical care, counseling.

Aktivitas Penangkapan Radikal Bebas dari Infus Kelopak Bunga Rosella yang Difermentasi dengan Lactobacillus Sartini, .; Lethe, Christiana; Frengky, .
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The research aimed to investigate the free radical scavenging activity of ethyl acetate fraction of roselle calyces infusion fermented by Lactobacillus casei strain Shirota against free radical agent, DPPH (2,2-di-phenyl-2-picrylhydrazyl). In sequence, the roselle calyces were extracted by infusion method with concentration at 5% w/v. The infusion was fermented using Lactobacillus casei strain Shirota during 3x24 hours at 37â°C. As regard the fermentation process, the result of that was extracted using ethyl acetate. Free radical scavenging activity was measured using DPPH method with unfermented-ethyl acetate fraction as control negative. As the result, both fermented and unfermented-ethyl acetate fraction exhibited free radical scavenging activity at 370.68 ppm and 685.49 ppm, respectively. These results suggest that antioxidant activity of fermented-ethyl acetate fraction could be 1.85 greater than unfermented-ethyl acetate fraction of roselle calyces infusionKeywords : Hibiscus sabdariffa L., Lactobacillus casei Shirota strain, free radical scavenging, DPPH

Analisis Penambatan dan Simulasi Dinamika Molekular Komplex Siklookgesinenase-2 dengan Beberapa Senyawa Turunan Kuinazolinon Yanuar, Arry; Setiajid, Muhammad Aditya; Hayun, .
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The aims of this research is to observe the inhibition activity of sulfonamides or sulfacetamides substituted of 3-Phenyl-2-styril-4(3H)-quinazolinones with COX-2. The study of COX-2, binding inhibition and dynamics interaction was done with in silico method by molecular docking with Auto Dock 4.0 and molecular dynamics in 2 nanoseconds with Amber 11. Those compound could be divided into 3 groups, based on Î?G scores of docking result: very selective group (-10.92 to -11.33 kcal/mol) compared to SC-558 (-10.90 kcal/mol); selective group compound (-9.22 to -10.68 kcal/mol) compared to celecoxib (-10.63 kcal/mol); non selective group, compound (-6.48 to -6.98 kcal/mol) compared to aspirin (-4.82 kcal/mol). Molecular dynamics simulation of 6COX complex with several quinazolinon derivates showed number and stability of hydrogen bond.Keywords : COX-2, anti-inflammatory, molecular docking, molecular dynamics.

Efek Imunostimulan Ekstrak Etanol Kelopak Bunga Rosella Wulandari, Dita; Puri, Putri Ratna; W, Ratna Kurnia; Nurkhasanah, .
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The aims of this study was to determine the immunostimulant potential ethanolic extract of roselle calyx through the proliferation of lymphocytes and phagocytosis ability of macrophages Balb/c mice in vitro. Dried calyx of roselle were extracted using 96% ethanol by maceration method is further polyphenols assay are qualitatively and quantitatively. Vitro test using with immunostimulants are seeing an increase in lymphocyte proliferation using the MTT method and phagocytosis activity macrophages with latex beads. Lymphocyte proliferation is expressed by the difference in absorbance values between treatment and control groups, where as the ability of phagocytosis is expressed as an index of phagocytosis and the SFA. Concentration of extract used was 10-1000 Î¼g/mL. Ethanolic extract of roselle calyc containing polyphenols with total polyphenol content (TPC) of 2.757%. Ethanol extract of roselle calyx enhanced immune response at low concentrations. Concentration Â of 100 Î¼g/mL is the optimal concentration that increased proliferation of lymphocytest. The highest index of phagocytosis and SFA are at concentrations of 150 Î¼g/mL and 250 Î¼g/mL. It can be concluded that ethanolic extract of roselle calyx has potential as immunostimulants.Keywords : roselle, immune response, macrophage phagocytosis, lymphocyte proliferation, immunostimulant.

Formulasi Sediaan Gel Niosom Kafein dan Usaha Peningkatan Absorpsi melalui Kulit Nafi'ah, Rahma; Darijanto, Sasanti Tarini; Mudhakir, Diky
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Cellulite is a condition in the skin that changes the topographic of the skin surface. Caffeine can be used as an active compound for its slimming effect. To improve the penetration into the skin and increasing its solubility for cellulite treatment, caffeine was formulated as niosome vesicles. Niosome was made by using thin layer hydration method. Span 60, caffeine and cholesterol dissolved in chloroform and evaporated to produse a thin layer. The dispersion of caffeine and niosome was formulated in the form of gel using 6% of HPMC gel base. To determine the formulation stability, caffeine niosome gel was stored at a room temperature and accelerated condition using climatic chamber at a temperature of 40â°C, 75% RH for 28 days. The result was then compared with caffeine gel. The diffusion rate of both gels was determined in vitro using flow through method. The results showed that the niosome system improved the solubility of caffeine up to 20,34 mg/ml and also showed that the pH and viscosity of caffeine niosome gel were stable under room temperature and accelerated condition.The diffusion test showed that the flux of caffeine niosome gel is 13.991 Î¼g/cm2Keywords : Caffeine, niosome, cellulite, diffusion test.

Teknik Isolasi Antosianin Utama dari Ekstrak Buah Ficus padana Burm.f dengan KCKT Tipe Standar Syukri, Daimon; Darwir, Djaswir; Santoni, Adlis
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Preparative High Performance liquid chromatography (HPLC) today is one of the popular methods to isolate anthocyanin from extract containing anthocyanins. The working principle of preparative-HPLC can be applied to the laboratory standard tupe of HPLC, so it can be used also to isolate the main anthocyanin compounds from anthocyanin mixtures. The function of fraction collector on preparative HPLC equipment were replaced by opening the mobile phase line after the exit of the detector and hold out the solution manually on the standard type of HPLC. Resolution value between the peaks and the computation time when cuts in the chromatogram peak collection mobile phase containing the analyte is of concern in these activities. The appearace of a single peak in the chromatogram of the isolates showed that the technique can be applied for the simple and fast technique of anthocyanins isolation.Keywords : isolation, anthocyanin, Ficus padana Burm.f, Preparative-HPLC, standar type of HPLC.

Kandungan Kimia dan Aktivitas Sitotoksik Ekstrak dan Fraksi Herba Anting-anting terhadap Sel Kanker Payudara MCF-7 Febriyanti, Maya; Supriyatna, .; Abdulah, Rizky
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Acalupha indica, belongs to Euphorbiaceae family, is annual herb which distributed widely in Asia, including Indonesia. Extract and fraction of Acalypha indica were sreened for phytochemical constituents and investigated for its cytotoxicity against human breast cancer MCF-7 using MTT assay. Ethanolic extract of A.indica showed cytotoxicity against MCF-7 with an IC50 225 Î¼g/ml. While for the fraction, ethyl acetate fraction showed best cytotoxicity compared to n-hexane and water fraction with an IC50 387 Î¼g/ml. Phytochemical screening to the ethyl acetate fraction showed that the fraction contain flavonoids, polyphenols, monoterpenes and sesquiterpenes, triterpenoids, and quinones.Keywords : Acalypha indica, cytotoxicity, MCF-7, MTT assay

Efek Glycine max Varietas Anjasmoro terhadap Kadar Timbal dan Malondialdehid pada Mencit Terintoksikasi Timbal Yulia, Rika; Karina, Lidya; Veronica, .; Christyaningsih, Juliana
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The objective of this research is investigating the effect of Glycine max Anjasmoro variety to mice with lead intoxication by measuring the levels of Pb in mice's (Mus musculus) blood and MDA in mice's liver and kidney strain BALB/C by using the thiobarbituric acid reactive substance (TBARS) assay. Research carried out by using 20 mice strain BALB/C that were randomly divided into four groups of five mice including negative control, positive control, treatment, and reference. All groups except positive control were intoxicated with lead in a dose of 25 mg/kg body weight for the duration of seven days. One gram of Glycine max has been given to the treatment group and positive control. There after 64 mg/kg body weight of vitamin has been given to the reference group. The results showed that Glycine max Anjasmoro varieties was significantly decrease the levels of lead in mice's blood and also reduce the levels of MDA in the liver and kidney although the results were not significant.Keywords : Glycine max Anjasmoro variety, lead, malondialdehyde, vitamin C, Mus musculus

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