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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
 1   2 
Search results for , issue "Vol 21 No 1 (2023): JIFI" : 20 Documents clear
Informasi Obat pada Pasien Diabetes Mellitus Rawat Jalan di RSUD X Surabaya: Apa yang diberikan dan apa yang diketahui? Shieny Agustin Santoso; Adji Prayitno Setiadi; Karina Kumaladewi Widjaja; Yosi Irawati Wibowo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1104

Abstract

The prevalence of Diabetes Mellitus (DM) in Indonesia has increased 0.5% in the last five years. This study aimed to evaluate information provided and level of knowledge among DM patients on their treatment at the outpatient clinic at the X Public Hospital (Rumah Sakit Umum Daerah, RSUD), Surabaya, Indonesia. This was a cross-sectional study using a checklist developed by The Food And Drug Supervisory Agency which consists of 11 types of information. The data were analysed descriptively; to test the relationship between the amount of information provided and the patient's level of knowledge, Spearman correlation analysis was used. A total of 110 patients were included in this study (response rate 90.91%). The mean of information provided and understood by patients was 6.48/11±0.73 and 7.48/11±0.90, respectively. There was a significant relationship between information provided to and known by patients (p=0.001). Characteristic factors such as age (p=0.001), education level (p=0.001), and sources of information related to DM (p=0.014) were shown to influence DM patients' knowledge of their treatment. This study indicated the importance of providing clear and complete drug information, especially for patients on long-term therapy, to improve their knowledge, thus potentially increasing adherence and optimizing therapy outcomes.
Batas Deteksi dan Sensitivitas Metode Deteksi Staphylococcus aureus dalam Sediaan Obat Nur Aini; Sitoresmi Triwibowo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1157

Abstract

Stapylococcus aureus is a pathogen that should be absent in pharmaceutical products. Contamination of certain microorganisms can potentially reduce or inactivate therapeutic activity, affect the stability, efficacy and cause infection of the patient. Microbial detection methods must be valid and sensitive to detect the contamination of microorganisms at low concentrations. The standard method of S. aureus refers to the Indonesian Pharmacopoeia (FI). LOD and sensitivity of the method in general is not stated in FI. This study aims to determine LOD and sensitivity of S. aureus method on pharmaceutical products with route of administration in cutan, oromucosal, gingival, auricular, vaginal and oral based on Indonesian Pharmacopoeia. Experiments used nine pharmaceutical products representing six dosage forms contaminated with S. aureus ATCC 6538 with three level concentrations of ±1, ±3, and ±5 CFU per g atau mL sample. LOD and sensitivity were determined and analyzed descriptively. This study shows that the detection limit is 1-3 colonies per g or mL sample and a sensitivity of 100%. Results of this study can be used as reference for LOD value in the validation or verification process of the S. aureus detection method in the laboratory to ensure validity of the methods used.
Evaluasi Sediaan Gel Anti Jerawat Kombinasi Ekstrak Etanol Daun Cabai Rawit dan Ekstrak Etanol Daun Sirsak Dimas Setiyono; Deden Mulya Prayoga; Herlan Budi Kusuma; Dina Febrina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1391

Abstract

Acne is a skin disease that usually occurs near adulthood. Acne is caused by several bacteria namely Staphylococcus epidermidis, Propionibacterium acnes, and Staphylococcus aureus. The alternative acne treatment uses cayenne pepper leaves (Capsicum frutescens L.) and soursop leaves (Annona muricata L.). The research aimed to find out the best formulation and activity of the ethanol extract gel of cayenne pepper leaves combined with the ethanol extract of soursop leaves as an inhibitor for acne-causing bacteria. This research is an experimental research type with 3 formulation designs, each of which was made with concentrations of ethanol extract from cayenne pepper leaves and ethanol extract from soursop leaves, namely F1 (1% and 1%), F2 (3% and 3%), and F3 (5 % and 5%), then tested the physical properties, antibacterial test and physical stability test of the preparation then analyzed the data with one-way ANOVA p-value <0.05. The results showed that the gel preparations were stable in terms of organoleptic, homogeneity, spreadability, adhesion, and viscosity, while there was a change in pH after the physical stability test using the cycling test method. The F2 gel preparation had the best bacterial inhibition, namely Staphylococcus aureus of 10.83 mm. Then the F3 gel preparation best inhibited Staphylococcus epidermidis bacteria by 9.56 mm and Propionibacterium acnes by 10.4 mm.
Efek Sindrom Antimetabolik Ekstrak Daun Etanol 70% Ficus carica Linn. pada Tikus yang Diinduksi Streptozotocin dan Diet Tinggi Lemak Rahmatul Qodriah; Shirly Kumala; Syamsudin Syamsudin; Nancy Dewi Yuliana; Vyacheslav Dushenkov; Carrista Carrista
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1399

Abstract

Diabetes and obesity are risk factors for metabolic syndrome. Fig (Ficus carica L.) one of the plants is well known in traditional medicine system for their medicinal and therapeutic potentials. Fig leaves contain flavonoid and triterpenoid compounds which have antimetabolic effect. Streptozotocin is used to make diabetogenic rats to produce hyperglycemia conditions in test animals and high-fat diet to make rats model obesity. This study aimed to test the antidiabetic and antiobesity effect of 70% ethanol extract of fig leaves based on the parameters of measuring blood glucose levels with glucometer and Cholesterol strips. In thisstudy, rats were divided into 6 groups, namely normal, negative, positive control, and 3 control groups at 70%ethanol extract dose level (250, 500, and 600 mg/kgBW) per oral. The measurement results in normal, negative, and positive control dose of 250, 500, 600 mg/kgBW at blood glucose levels were 105.8, 192, 134.2, 161, 157.75, 145.2 mg/dL. The conclusion of the results obtained was that 70% ethanol extract of fig leaves with a dose of 600 mg/kgBW can have an antidiabetic and obesity effect by lowering blood glucose levels as measured using glucometer, cholesterol strips and decreased body weight rats.
Potensi Sitotoksik Akar Kedayan (Aristolochia foveolata Merr.) pada Sel Telur Tripneustes gratilla Terfertilisasi Syuhada Syuhada; Benazir Evita Rukaya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1130

Abstract

The cytotoxicity test is a screening test used to evaluate the reaction of live cells to implants in cell culture tests. This study aims to determine the cytotoxic activity of akar kedayan in fertilized Tripneustes gratilla eggs, which have an impact on inhibiting the development of fertile cells. This study used an experimental method by comparing the inhibition of Tripneustes gratilla egg cell division in the ethanol extract group of akar kedayan at concentrations of 10, 100, and 1000 ppm, with negative control, then observing embryo cell division at 1, 2, 4, and 12 hours. After fertilization, a comparative statistical analysis was conducted using the ANOVA test, followed by the Tukey HSD Post Hoc Test. The results showed that the negative control and 10 ppm concentration did not inhibit the division of the fertile Tripneustes gratilla eggs (P-value>0.05), while the ethanol extracts of 100 and 1000 ppm significantly inhibited the division of Tripneustes gratilla eggs (P-value< 0.05). This study concludes that the ethanol extract of akar kedayan has cytotoxic ability by inhibiting the development of Tripneustes gratilla fertile eggs with the optimum cytotoxic dose range at concentrations of 10-100 ppm.
Tata Kelola Obat JKN: Peran Badan Penyelenggara Jaminan Sosial Kesehatan (BPJS-K) dalam Belanja Obat Strategis Yusi Anggriani; Nurita Andayani; Mawaddati Rahmi; Rasta Naya Pratita; Prih Sarnianto; Atmiroseva Atmiroseva; Erfan Chandra Nugraha; Citra Jaya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1371

Abstract

The National Health Insurance System (JKN) has social and equity insurance principles aiming participants receive basic health benefits. This raises must-have other requirements for circulated medicine, namely availability and accessibility. Thus, this must meet the elements of safety, efficacy/ benefits, good quality, market availability, and easy accessibility. However, drug shortages problem still occurs and ranks 3rd for BPJS Kesehatan services complaints. This study is to identify opportunities and constraints of BPJS in strategic health purchasing to increase access to JKN medicine . This is a crosssectional study using quantitative and qualitative methods. Quantitative research uses Structural Equation Modelling (SEM), while qualitative uses Focus Group Discussion (FGD). This found the problem roots related to JKN medicine shortages, including limited human resource capabilities, in optimal planning processes, e-purchasing method constraints, e-purchasing system and manual purchases medicine prices differences, medicines ordering long lead time, and in optimal BPJS Kesehatan role as a strategic health purchaser. Therefore, it is to increase BPJS Kesehatan’s role as an active purchaser by making an information system for all medicine use in JKN services, forming a Drugs Advisory Board/JKN drug working group and coordination between policy-making institutions to optimize BPJS Kesehatan role in ensuring JKN medicines access.
Pola Penggunaan Obat Pada Masa Pandemi Covid-19: Studi Kasus di Rumah Sakit Umum Pusat Persahabatan Fitri Nurhayati; Dendhi Bagus Andriyanto; Fadhila Putri; Rara Merinda Puspitasari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1396

Abstract

The COVID-19 pandemic condition has encouraged healthcare practitioners to adapt and constantly work to meet the needs of those who require healthcare, including medication supply. This study aims to provide the drug use patterns prior to and throughout the COVID-19 pandemic. This retrospective descriptive study analyzed the drug use patterns of 10 fast-moving drugs obtained through purposive sampling, as well as all medications listed in COVID-19 guideline therapy at Persahabatan general hospital. The drug use data was derived from the quarterly data from 2019 through the second quarter of 2021. The result showed that there was an increase and variation in the sampled drug usage. The top-ranking classes that have shown an upward trend during the COVID-19 pandemic were Vitamin C 500 mg tablet, Vitamin C 200 mg injection, and Vitamin D3 5000 UI tablet. Meanwhile, non-COVID-19 medicines with reduced use include Cefotaxime 1 g, Cefixime 200 mg, and Docetaxel 20 mg. Therefore, it is necessary to analyze the drug utilization continuously and as frequently as feasible throughout the pandemic and plan in stages. Forecasting demand for medicines is essential for an effective medicinessupply chain, in particular in a pandemic context to avoid shortages or overstock.
Potensi Penghambatan Enzim Tirosinase dengan Ekstrak Etanol Terstandar dan Fraksi Etil Asetat Kulit Bengkoang (Pachyrhizus erosus L. Zainur Rahman Hakim; Ratna Djamil; Novi Yantih; Ocitania Sanasih; Benny Iskandar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1397

Abstract

This study examined the tyrosinase inhibitory potential of bengkoang peel standardised ethanolic extract and ethyl acetate fractions. 450 g of bengkoang peel powder (Pachyrhizus erosus L.) was macerated with 96% ethanol for 2 x 24 h, filtered, and concentrated till viscous. Extract standardisation uses specific and non-specific parameters. Microplate colorimetric tyrosinase inhibition assays were performed. The result of plant determination identified the bengkoang peel as Pachyrhizus erosus (L.) Urb. The organoleptic test revealed a brownish-yellow viscous extract, fresh smell, and bitter taste. Ethanol-soluble extract was 47.60% and water-soluble 22.42%. Bengkoang peel ethanolic extract includes alkaloids, flavonoids, saponins, tannins, and steroids. The non-specific parameters showed loss of drying (9.71%), water content (7.28%), total ash (9.91%), acid-insoluble ash (3.68%), no residual solvent content, lead content (-0.2324±0.1729), cadmium content (-0.0841±0.3418), TPC of 1 x 101 CFU/g, and TYMC of 2.26 x 102 CFU/g. The ethanol extract (103.9263) and ethyl acetate fraction (81.8606) IC50 values of bengkoang peel decrease tyrosinase enzyme activity compared to control (25.1235 ppm). These results show that the ethanol extract met both particular and non-specific quality standards. Bengkoang peel ethyl acetate inhibited tyrosinase.
Analisis Pengetahuan, Kepatuhan, dan Outcome Klinis Pasien Hipertensi di Puskesmas Jetis Yogyakarta Husna, Nadia; Sugiyono, Sugiyono; Yunilistianingsih, Yunilistianingsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1100

Abstract

Hypertension has been an increasing global epidemic problem over years and considered as one of the deadly disease with a high cardiovascular complication risk. Knowledge and adherence play an important role in patient's clinical impact, which determined the level of medication’s adherence. Thus, adherence level determines the achievement of clinical outcome. The optimum clinical optimum will be achieved if the adherence level is at good level. The method in this study was using observational analytics with a cross sectional approach. The sampling method was consecutive sampling. The subjects were the adult hypertensive patients at Puskesmas Jetis Kota from August until October 2020. Univariate analysis was conducted in patient’s and medication characteristics. Kendal Tau test was used to analyze the relationship between adherence and clinical outcome. 81 hypertensive patients were included in this study. The highest prevalence of patient’s characteristics were shown on the women’s group: 45-59 years old, senior high school education background, and no occupation. Amlodipine was the highest medication used as a single therapy. It was found that there is no relationship between knowledge and adherence level. In addition to that, there was no relationship between adherence level and clinical outcome measured by systole and diastole.
Pola Peresepan Antibiotik pada Pasien Komplikasi Diabetes Melitus di RSUD Panembahan Senopati Bantul Eva Nurjanah; Daru Estiningsih; Nurul Kusumawardani; Ninisita Sri Hadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1150

Abstract

Diabetes Mellitus, one of the non-communicable diseases (NCDs), is the leading cause of death in addition to cardiovascular disease, cancer, and chronic respiratory disease. The Basic Health Research (Riskesdas) recorded that Yogyakarta experienced a prevalence increase of 97% in 2013-2018, the second-highest in Indonesia. Uncontrolled sugar levels cause deterioration of the immune system. This study aims to determine the pattern of prescribing antibiotics and the occurrence of comorbid complications, both infectious and non-infectious. This was a non-experimental descriptive study with a cross-sectional design. The data was collected from patient's medical records retrospectively from July to December 2019. Furthermore, 65 medical records were taken using a simple random sampling method. A descriptive statistical analysis was performed, and the results were presented as percentages. The percentage of infectious and non-infectious comorbid diabetes mellitus II in Panembahan Senopati Bantul Hospital was 22.2% and 77.8%, respectively. The prescribing pattern primarily used was ceftriaxone (23.5%). The antibiotic class mainly prescribed was cephalosporin (49%).

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